Rat
Rat
Rat
Introduction
Rattus norvegicus (“Norway rat”)
Laboratory rat
Pet rats
Came from Asia to Europe at the
beginning of 1700’s
Rattus rattus (“black rat”)
Many strains (inbred- brother/sister matings for
20 generations) and stocks (outbred) used in
research
Outbred stocks used as pets
Norway Rat
Albino
Wild
Black Rat (Rattus rattus) has faded
away
Strains & Stocks
Common outbred rat stocks:
Wistar, Sprague-Dawley, Holtzman
(albino)
Long-Evans (“hooded”)
Smart, sociable, docile, trainable
Excellent pets if handled gently
Hooded Rat
Wistar
Wistar
Terminology
Function:
Stores Glycogen
Regulate Temperature
Anatomy & Physiology
Stomach anatomy (limiting ridge)
prevents vomiting
No gallbladder
Rat Stomach
Male Female
Reproductive Physiology
Puberty ~ 2-3 mo. (strain variation)
Maximal fertility 3.5-10 months of age
Estrous cycle length: 4-5 days
Copulatory plug left by male
Can palpate pregnancy by 12 days of
gestation
Gestation length 19-23 days (avg=21)
Parturition
Nest-building ~ 5 days prepartum
1.5-4 hrs prepartum = fluid discharge
Parturition takes 1-2, to several hrs.
Dystocia is rare
Average litter size is 6-12 pups
Cannibalism in rats means dam is
stressed
Parturition and Neonatal Life
Pups are altricial (helpless), hairless, and
nidicolous (blind)
In utero maternal antibody transfer and
via milk until around day 21 of age
More rats!!!
Females go into heat between about 10 and
24 hours after giving birth. Specifically,
females go into heat on the first evening that
is at least 10 hours after giving birth (Gilbert
et al. 1985). This phenomenon of coming into
heat shortly after giving birth is called
postpartum estrus.
Timed Pregnacies
Vaginal smears
Groups of females housed with a male and monitored
Rats usually mate at night
After mating (post coitus) a vaginal plug forms and
falls out in about 24 hrs.
Place a dark paper on cage floor and look for the
plug to confirm mating
Then remove male
Rat Pup Development
Incisors erupt at 6-8 days
Fully haired by 7-10 days
Eyes open at 10-12 days
Weaning at 21 days
Lifespan: 2.5 - 3 years
Adult weights:
Female ~ 250-300g
Male ~ 300-600g
Behavior and Handling
Docile, easily trained
Nocturnal
Coprophagic
Males are more sociable than females
mice
Males prefer company but tolerate single
housing
No musty odor like mice
Males can be housed together
Females can be housed together, post
parturient females may fight among.
Housing & Husbandry
Most rats are housed in
shoebox cages composed of
polypropylene (opaque) or
polycarbonate material
(clear) with a wire bar lid
used to hold the water bottle
and feed.
Bedding is placed directly
into the shoe box cage
allowing the absorption of
urine and the animal to
burrow.
This type of cage will hold 1-
3 adult rats depending on
the size of the cage
Housing & Husbandry
Caging: “Shoe-box”
Germ free
SPF (specific
pathogen free)
Conventional
Solid floor
Housing & Husbandry
Optimal temperature range: 65-79 °F
Keep humidity >40% to prevent ringtail
Water requirement:
10ml water/100g BW/24 hrs
Medicating water may reduce intake
Pelleted natural ingredient diets are used to
feed all rodents and are composed primarily
of cereal grains which are supplemented with
additional protein, vitamins and minerals
Balanced all-in-one pelleted diet
5 g food/100g BW/24 hrs
Do not supplement: obesity