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    Streptokinase Group

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    Definiation of Streptokinase Pharmacologic class storing Pharmacokinetics Indications & usage: Dosage and Administration Nursing consideration: Contraindications: Side Effect: Antidote of Streptokinase

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    Streptokinase Group

    Uploaded by

    Suffocated Live
    401 views16 pages
    Definiation of Streptokinase Pharmacologic class storing Pharmacokinetics Indications & usage: Dosage and Administration Nursing consideration: Contraindications: Side Effect: Antidote of Streptokinase

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    Definiation of Streptokinase Pharmacologic class storing Pharmacokinetics Indications & usage: Dosage and Administration Nursing consideration: Contraindications: Side Effect: Antidote of Streptokinase

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    401 views16 pages

    Streptokinase Group

    Uploaded by

    Suffocated Live
    Definiation of Streptokinase Pharmacologic class storing Pharmacokinetics Indications & usage: Dosage and Administration Nursing consideration: Contraindications: Side Effect: Antidote of Streptokinase

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
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    Streptokinase is a protein secreted by streptococci bacteria that can activate plasminogen and dissolve blood clots. It has applications in treating myocardial infarction, pulmonary embolism, and deep vein thrombosis.

    Streptokinase is a protein that is secreted by certain bacteria. It binds to and activates plasminogen in the blood, converting it to plasmin which breaks down blood clots.

    The main indications for use of streptokinase include acute myocardial infarction, pulmonary embolism, deep vein thrombosis, arterial thrombosis, and embolism.

    Streptokinase

    Streptokinase:
    Is a protein secreted by several
    streptococci, it can bind &
    activate human plasminogen to
    convert to plasmin.

    : Generic name
    .Streptokinase

    :Brand (trade) name


    Kabikinase, Streptas ( names
    registered medication in Saudi Arabia
    .according to FDA)

    : Therapeutic class
    .Thrombolytic enzyme

    : Pharmacologic class
    . Tissue Plasminogen Activator

    Pharmacology:
    Converts plasminogen to the enzyme
    plasmin, which aids in dissolution of
    blood clots.

    :Available forms
    The only available form is powder.

    :Administration
    .
    IV ( intravenous route )-1
    .IC ( intracoronary route )-2
    :Action
    Dissolve clot that have formed in blood
    .vessels

    Storage/Stability:
    Store unopened vials at controlled room
    temperature (59 to 86F). Use
    reconstituted solution immediately or
    within 8 h if stored at
    36 to 46F. Discard any unused

    Pharmacokinetics

    Metabolism:
    No metabolites identified.

    Elimination:
    Streptokinase is cleared by the liver.
    The half life is approximately 23 .

    :Indications & usage

    . AMI- 1
    lysis of intracoronary thrombi improvement of
    ventricular function, and reduction of mortality
    associated with acute MI; reduction of infarct size and
    .CHF associated with acute MI
    .
    Pulmonary Embolism-2

    .DVT-3
    acute, extensive thrombi of the deep veins (eg, those
    involving the popliteal vessels); lysis of acute arterial
    thrombi and emboli; alternative to surgical revision for
    clearing totally or partially occluded arteriovenous
    cannula when acceptable flow cannot be achieved.

    Dosage and Administration

    Acute MI (Adults):
    IV infusion Administer ASAP after symptom onset
    (greatest benefit when administered within 4 h, but
    benefit has been reported up to 24 h). Infuse a total
    dose of 1,500,000 units within 60 min.
    Intracoronary infusion Administer 20,000 units by
    bolus followed by 2000 units/min for 60 min (total
    dose, 140,000 units).

    PE , DVT, Arterial Thrombosis, or Embolism


    (Adults):
    IV infusion Administer ASAP after onset of thrombotic
    event, preferably within 7 days. A loading dose of
    250,000 units infused into a peripheral vein over 30
    minutes has been found appropriate in over 90% of

    :Nursing consideration

    .Monitor Coagulation profile 1


    checking ECG & Vital signs-2
    Be aware if patient has had either recent-3
    streptococcal infection or recent treatment with
    .streptokinase, higher loading dose may be necessary
    Check hypersensitivity reactions, give 100 unit-4
    intradermal, as ordered; wheal & flare response within
    .20 minutes means patient is probably allergic
    .Notify doctor immediately if hypersensitivity occur-5
    Keep corticosteroids and aminocaproic acid available -6
    .to treat allergic reaction and bleeding

    Contraindications:
    1-Active internal bleeding.
    2- Recent cerebrovascular accident
    (within 2 months).
    3- Intracranial or intraspinal surgery
    4- Severe uncontrolled hypertension.

    Side Effect:

    1- Bleeding.
    2-Allergic reaction.
    3-Sever kidney disease.
    4-Dameg to the blood vessels
    and others.

    Notify the doctor immediately if the


    patient complain of any of the
    following:
    1-Blurred Vision.
    2-Dizziness.
    3-Fever.
    4-Sweating.

    Streptokinas
    e:
    Aminocaproic
    acid.

    Thank you

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