Novel Drug Delivery System
Novel Drug Delivery System
Novel Drug Delivery System
Rassoul Dinarvand
Professor of Pharmaceutics
Pharmaceutics 5
Drug levels in the blood with (a) traditional drug dosing and (b) controlled-delivery
dosing
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Chemical engineering
Pharmaceutical engineering
Particle engineering
Solid lipid particles
Dendrimers
Mechanical engineering
Mechanical pumps
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Reservoir devices
-
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Biodegradable polymers
-
Simple release mechanism, but difficult to obtain fine control over degradation
Poly(lactide-co-glycolide) (PLGA)
Examples in use
-
Resomer (PLGA)
Vicryl (PLGA)
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Hydrogels
] [
O
O
OH
O
O
HEMA
>95 parts
polymerise
O HO
O
O
O
O
OH O
Monomer (water-soluble)
Cross-linker
Hydrogel
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Mucoadhesives
] [
O
OH
O
n
Methacrylic acid
(MAA)
Poly(ethyleneglycol)
dimethacrylate
PEGDMA
polymerise
HO
OH
Adhesive
groups
O
O
[
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Type of polymer
Non-degradable / Degradable
Type of Design
Reservoir
Matrix
Release mechanisms
Diffusion / polymer degradation / combination
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Drug delivery from (a) reservoir and (b) matrix swelling-controlled release systems
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Molecular gates for the delivery of insulin triggered by the presence of glucose
in the bloodstream
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Drug delivery from (a) bulk-eroding and (b) surface-eroding biodegradable systems
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Polymer
Non-degradable
Degradable
Design
Reservoir
Matrix
Reservoir
Matrix
Release
Removal
Rupture
Low Mw
High Mw
Duration
5 years
5 years
1-2 years
Months
Examples
Norplant
Jadelle
CapronorTM
Microspheres
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Jadelle
Norplant
Own work
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Particulate
systems
Nanoparticles
Nanocapsules
Nanospheres
Microparticles
Microspheres
Microcapsules
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Films
Membranes
Fibers
Rods
Beads
Discs
Cylinders
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Diffusion
Concentration gradient in polymeric
matrix
Chemical reaction
Polymer biodegradation
Solvent effect
Release of soluble drugs in hydrogels
Mechanical release
Drug release from mechanical devices
such as pumps
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Implants
Injectables
Transdermal
Oral
Nasal
Ophthalmic
Vaginal
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Solid tumor
Apply magnetic
field to concentrate
particles
Modulate field to
release drug from
particles
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