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Congestive Heart Failure: Adopted From: Jarrod Eddy, PGY2 Internal Medicine Sub-I Lecture Series

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Congestive Heart Failure

ADOPTED FROM: Jarrod Eddy, PGY2 Internal Medicine Sub-I Lecture Series

Congestive Heart Failure


Clinical presentation of disease NOT a diagnosis in and of itself Differential includes
Underlying cardiovascular disease Precipitating factors

Predisposing Cardiac Diseases


Myocardial infarction Chronic ischemia Cardiomyopathy Arrhythmias Diastolic dysfunction Valvular diseases
Aortic Stenosis Mitral Stenosis Mitral Regurgitation

Cardiac Physiology
(remember this?) CO = SV x HR HR: parasympathetic and sympathetic tone SV: preload, afterload, contractility

Preload
Def: Passive stretch of muscle prior to contraction Measurement: Swan-Ganz
LVEDP

Really a function of LVEDV Affected by compliance


Low compliance = higher LVEDP @ lower LVEDV False high estimate of preload

Frank-Starling right?

Afterload
Def: Force opposing/stretching muscle after contraction begins Measurement: SVR Really a function of:
SVR Chamber radius (dilated cardiomyopathies) Wall thickness (hypertrophy)

Contractility
Def: Normal ability of the muscle to contract at a given force for a given stretch, independent of preload or afterload forces In other words:
How healthy is your heart muscle?

Ischemia, Hypertrophy (?), Muscle loss

Classifying Heart Failure


Anatomically
Left versus Right

Physiologically
Systolic versus Diastolic

Functionally
How symptomatic is your patient?

Left versus Right Failure


Left Heart Failure - Dyspnea - Dec. exercise tolerance - Cough - Orthopnea - Pink, frothy sputum Right Heart Failure - Dec. exercise tolerance - Edema - HJR / JVD - Hepatomegaly - Ascites

Systolic versus Diastolic


Systolic cant pump
Aortic Stenosis HTN Aortic Insufficiency Mitral Regurgitation Muscle Loss
Ischemia Fibrosis Infiltration

Diastolic- cant fill


Mitral Stenosis Tamponade Hypertrophy Infiltration Fibrosis

Physical Exam
no distress at rest, except for feeling uncomfortable when lying flat for more than a few minutes Decreased pulse pressure cool peripheral extremities and cyanosis of the lips and nail beds Increased jugular venous pressure Rales Hepatomegaly Peripheral edema

Clinical Data
CXR
Kerleys lines : A and B Pulmonary Edema Cephalization Pleural Effusions (bilateral)

EKG
Left atrial enlargement Arrhythmias Hypertrophy (left or right)

Cardiomyopathy

Pulmonary Edema

Clinical Data
HEART SOUNDS!!! Systolic Murmurs
Mitral Regurg Aortic Stenosis

Diastolic Murmurs
Mitral Stenosis Aortic Insufficiency

S3: Rapid filling of a diseased ventricle

Clinical Data
Laboratory Data Chemistry
Renal Function: Be Wary

BNP
Used in ER departments the world over Good negative correlation Need baseline for positivity Pulmonary versus cardiac dyspnea

Treatment of CHF
Treat Precipitating Factor(s)!!!! Adjust Heart Rate Decrease Preload Decrease Afterload Increase Contractility Increase Oxygenation

Treatment of CHF
Oxygen nasal, BiPAP, intubation Morphine Preload Reduction
Loop diuretics Nitrates ACEi / ARB Morphine

Treatment of CHF
Afterload Reduction
IV NTG, Nitroprusside Hydralazine ACEi / ARB

Ionotropic Support
Dopamine / Dobutamine Amrinone / Milrinone Digoxin (chronic) Mechanical (ABP)

Treatment of CHF
Beta-Blockers
Chronic > Acute Carvedilol (Coreg), Metoprolol (Toprol XL)

Fluid Balance
Restrict fluid / salt intake Monitor I/Os and daily weight Dialysis if needed

Aspirin

Precipitating Factors
Infection Pulm Embolus Noncompliance Arrhythmia Myocardial Infarction Stress reaction Sodium Intake Medications!!! Anemia Thyroid disorders Endocarditis

Admission Orders
Admit: Telemetry or ICU EKG STAT, then daily x 3 days 2D Echo CXR Labs: BMP, CBC, CE x 3, Coags, LFTs, UA Pulse ox (ABG) Oxygen ASA 325mg PO daily

Admission Orders
Nitroglycerin
Paste: 1 ACW TID Holding parameters IV: 50mg in 250cc D5W Titrate

Morphine 1-5mg IV q10-20 min prn Lasix 20-200mg IV (q 6-8 hours) ACEi
Captopril 6.25-50mg PO q8h Enalapril 2.5-20mg PO BID (0.625-2.5mg IV q6h)

Hydralazine 10-100mg PO q6-8 h

Admission Orders
Beta Blocker
Probably not acutely Start Coreg or Toprol XL prior to discharge

Fluid Restrict 1000ml daily Low salt diet Daily patient weights Daily I/Os

Admission Orders
Dobutamine 500mg in 250cc D5W
3-10ug/kg/min

Digoxin
Probably not acutely Titrate to effective dose prior to discharge

IABP
Cardiogenic shock unresponsive to above tx

Dialysis
Critical renal failure patients

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