My Understanding of Freddds Protocol
My Understanding of Freddds Protocol
My Understanding of Freddds Protocol
PLEASE NOTE:
These are generalized guidelines, and everyone's process is very individual. You must do your own research
to make sure that your implementation of the protocol is appropriate and safe for you. Keep a detailed
journal. These are simply my notes in attempting to make sense of how to apply this protocol to me, and
since I wrote it all up anyway, I figured I might as well share. I'm certain that all your questions will not be
answered here, all my questions are not even answered here. This is just the synthesis of the info that
I have collected so far. Ive tried to make it clear when the information comes from Freddd (to the best of
my research/understanding) and where it comes from me, apologies in advance for any
confusion. - SHECLIMBER
PROTOCOL OUTLINE
1. Remove all supplements containing Hydroxocobalamin, Cyanocobalamin, Folic Acid, Glutathione, and
Glutathione precursors such as NAC, Glutamine, and undenatured whey.
2. Supplement with Basic Cofactors for about a week.
3. Titrate B12s and adjust Methylfolate and Potassium (and possibly B1, B2, and B3) as needed to
eliminate deficiency symptoms.
4. Titrate L-Carnitine Fumurate (LCF) to effectiveness.
5. Titrate SAM-e.
6. Titrate Trimethylglycine (TMG, aka Betaine). If it does nothing, discontinue.
7. Titrate Biotin.
8. CNS Penetration Test.
titrate (verb): continuously measure and adjust the balance of (a physiological function or dosage).
STEP 1
Remove all supplements containing Hydroxocobalamin, Cyanocobalamin, Folic Acid, Glutathione,
and Glutathione precursors such as NAC, Glutamine, and undenatured whey.
Hydroxocobalamin and Cyanocobalamin are inactive forms of B12; Cyanocobalamin is artificial, meaning it
is not present in nature. Folic Acid is also artificial.
Glutathione induces immediate deficiencies in active B12, apparently by converting active MeCbl to inactive
GlutathionylB12 and rapidly excreting it.
STEP 2
Supplement with Basic Cofactors for about one week.
6 ml FCLO (one
Vitamins A & D from Green Pastures FCLO syringe to 5ml mark) =
fish oil 10950 A, 2565 IU D
(approx)
NatureMade B-Complex
with C - Per 1 capsule:
15mg B1 (as
Thiamin Freddd: B-complex and
Mononitrate) methylfolate need to
10.2mg be taken twice a day
B2 (Riboflavin) because of short serum
50mg B3 (Niacin half-lifes for best
as Niacinamide) effectiveness
B-complex that includes 5mg B6 (as
P-5-P, biotin and Pyriodoxine Freddd: Daily doses of
pantethine without Hydrochloride) B1 and B2 above 20-
Cyanob12 or folic acid 10mg 30mg a day and B3
Pantothenic Acid above 100mg a day
(as d-Calcium can cause an insatiable
Pantothenate) need for methylfolate
Missing biotin and and potassium.
others which will
need to be added
individually, but
worth it for low
B1, B2 and B3
1:1 magnesium:calcium
Seeking Health
Zinc - 50mg/day Trace Mineral
Complex (I or II)
These cofactors may be included now, later, or not at all - at your discretion:
ALA - Alpha
Freddd: enhances LCF and AdoB12
Lipoic Acid
STEP 3
Titrate B12s and adjust Methylfolate and Potassium to sufficiency as needed to eliminate
deficiency symptoms.
Supple Starting
Target" Dose Freddds Brand(s) Notes
ment Dose
15-20mg/day
as little as a a.k.a. Methylcobalamin or
with no Enzymatic Therapy B12
MeB12 quarter of a MeCbl; one active form of
noticeable Infusion
tablet B12
response
Anabol Naturals
10mg/week
as little as a Dibencoplex a.k.a. Adenosylcobalamin,
with no
AdoB12 crumb of a AdoCbl, or Dibencozide; the
noticeable
tablet Source Naturals other active form of B12
response
Dibencozide
As needed to
avoid
insufficiency
Solgar Metafolin
1-3 doses of symptoms - Take away from potassium
Folate 800mcg or 1000mcg
400mcg usually between by 30-45min
Tablets
16mcg and
30mg/day (yes
mg)
As needed to
Brand not that Take away from folate by
avoid
important, but NOW 30-45min; Ignoring
Potassiu 300mg every insufficiency
Potassium Gluconate symptoms of potassium
m several hours symptoms -
powder is probably deficiency can by
maybe up to
best if it works for you. dangerous and even fatal.
3000mg/day
3a. Start MeB12
Place 1mg MeB12 (1 tab Enzymatic Therapy) between your lip and gum. Let dissolve until the neurological
brightening (or whatever effect you experience) is as intense as you are willing to allow and then chew and
swallow. The absorption stops in minutes and so does the increase in brightening.
Freddd: "Of course if you are more like me, I held it for an hour. At the end of the hour life long depression
had lifted, the abnormal fatigue was on the way out and about 50 symptoms were starting to change and
much reduced within a month. Each time the brightening went down at the dose I was on I increased the
dose. It took me 4 months to go from 1mg to 5mg and 4 months to go from 5 to 20mg. Then after that
went to zero immediate noticeable effect I did the 50mg test."
Freddd: "At about 3 days in after starting the methylfolate symptoms making you feel rather sick may
start. They are usually both folate deficiency symptoms on some levels and low potassium. Those need to
be identified by the list of symptoms and the deficiencies corrected by titration. "
Reference: Symptoms List 1/4/15 with Start-Up Timings; Symptoms List 1/9/14
Increase each of these doses (by adding another 1/2-1 tablet per dose), or add additional doses, up to 5mg
a day or more until insufficiency symptoms start going down. Freddd: "This is usually between 1600mcg
and 20-30mg depending upon how one reacts to other folates and B1, B2, B3."
Methylfolate is absorbed better with food, but is ok without. It should be taken away from Potassium.
Potassium you can take 300mg every several hours with water until symptoms start to go down and stay
down. Wait 45 minutes after taking Methylfolate before taking Potassium.
Freddd: "The potassium can be taken at 300mg per several hours with water until the symptoms start
going down and stay down. These can go away for an hour and be back because of serum halflife issues in
another 2 hours. Many have to increase by 2000-3000mg of potassium daily."
DO NOT IGNORE SYMPTOMS OF POTASSIUM DEFICIENCY. IT CAN PUT YOU IN THE HOSPITAL AND EVEN
BE FATAL.
Freddd: "People appear to be bimodal or more on the AdoCbl as to balance and frequency of doses. I did up
to 50% daily, and down to once a month. Once a week with a large CNS dose during 6 hours seems to
work best for me. My daughter needed a tablet every day, along with even more MeCbl. When I took it
every day I didn't feel as good as just MeCbl. It affected my mood a bit, more "irritated". Taking both the
first day seems to be a good idea as a near complete lack of either isn't good. The thing is some people
need it every day in serum where others do fine with the AdoCbl in place in the mitochondria being
renewed regularly."
Quote source: http://forums.phoenixrising.me/index.php?threads/reformulated-anabol-dibencomplex-
sublingual.35004/#post-547808
Freddd: "The slower you go the longer the intense reactions last. Remember, the first thing MeCbl does for
most people is increase the intensity of the senses. EVERYTHING IS PERCEIVED MORE. I found the
difference between 1mg and 5mg imperceptible to most people and that 5mg a day brings perceivable
response down to zero faster."
Freddd: "If you check the so called "overmethylation" symptoms they are usually deficiency symptoms,
often of AdoCbl. People often confuse ATP startup for "over methylation". I judge the effectiveness of these
various theories by who has healed with them. I've healed from FMS and CFS and congestive heart failure.
However, I was a hyper responder to methyB12 If I had let that scare me off I likely would have died 10
years ago."
STEP 4
Titrate LCF to Effectiveness.
LCF, the 4th of the Deadlock Quartet:
MeCbl, AdoCbl, MethlyFolate and Carnitine make up what Freddd calls the Deadlock Quartet. Carnitine
works with AdoCbl and a lack of Carnitine can completely prevent it's effectiveness to increase energy,
improve aerobic endurance, improve mood, etc.
Doctor's Best L-
500- For a small percentage of
Carnitine Fumurate
1000mg/day people Acetyl-L-Carnitine might
(one 855mg cap =
L-Carnitine 125mg/da where an work better; Jarrow Liquid
500mg Carnitine)
Fumurate y increase of Carnitine (freebase) might be a
250mg makes good starting point for those
Source Naturals is
no difference. with anxiety.
also OK
Start with 125mg and titrate up to 500-1000mg per day, where an increase of 250mg more makes no
difference. Go slow, it could take 6 months to titrate up to one 855mg capsule (500mg of Carnitine) per
day.
Take Carnitine on an empty stomach - 30 minutes or so before food or at least 2 hours after.
STEP 5
Titrate SAM-e.
SAM-e makes MeCbl more effective, possibly much more effective. It increases energy and improves mood.
Start with 100mg (1/2 tablet) and move up to around 200-600mg/day.
STEP 6
Titrate TMG. If it does nothing, discontinue.
TMG enhances the effects of SAM-e, MeCbl, and L-Carnitine. It can also ease the intensity of ATP
production starting up. Start around 250mg (1/2 tablet) or less.
STEP 7
Titrate Biotin.
STEP 8
CNS Penetration Test.
After this then the CNS penetration test is tried. The CNS effect is normally far more subtle than the body
startup and if there is any body startup left, it overwhelms the CNS effects making the CNS trial less
effective. Each of these two trials can let you know if you have difficulty with B12 entering the cerebral
spinal fluid. It appears to be a transport problem of unknown cause which many with neurological diseases
have, including FMS and CFS.
8a. MeB12 Penetration Test
The CNS can be tried with MeB12 first, first 2 tablets, adding one each half hour to total.
Freddd: "Right now SC injection of 7.5mg to 10mg MeCbl appears to be a CNS penetrating dose. I use
3x10mg injections daily to maintain my CNS level of MeCbl. If I only do twice a day I have some startup
each time. FOr me it takes 3 for equilibrium. Good luck."
RESOURCES