Disorders of Copper Homeostasis and Homoeopathy
Disorders of Copper Homeostasis and Homoeopathy
Disorders of Copper Homeostasis and Homoeopathy
Dr.
Dr.
Dr.
Dr.
Dr.
Rajneesh Kum
Swati Vishnoi
Preetika Lakh
Mohammad Ta
Mohammad Ta
Disorders
of
Homeostasis
Homoeopathy
Copper
and
Contents
Introduction........................................................................................................... 2
Primary or genetic disorders of copper metabolism..............................................2
Menkes disease.................................................................................................. 2
Pathophysiology of Menkes disease................................................................2
Occipital horn syndrome..................................................................................... 2
Pathophysiology of Occipital horn syndrome...................................................3
Wilson disease.................................................................................................... 3
Pathophysiology of Wilson disease..................................................................3
Sign and symptoms of Wilsons disease...........................................................3
Aceruloplasminemia........................................................................................... 4
Pathophysiology of aceruloplasminemia.........................................................4
Albumin Christchurch disease............................................................................ 4
Secondary disorders of copper metabolism...........................................................5
Tyrolean infantile cirrhosis.................................................................................. 5
Pathophysiology.............................................................................................. 5
Indian childhood cirrhosis................................................................................... 5
Idiopathic copper toxicosis.................................................................................5
Disease-induced changes in copper homeostasis..............................................6
Treatment.............................................................................................................. 6
Homoeopathic treatment.................................................................................... 6
Common remedies for Copper homeostasis....................................................6
Short repertory of Copper homeostasis...........................................................7
Bibliography......................................................................................................... 10
Introduction
There are certain disorders of copper metabolism which cause mild to fatal
manifestations in human body. They fall into either primary or secondary
categories
Primary disorders of copper metabolism are genetic disorders likeo Menkes disease
o Occipital horn syndrome
o Aceruloplasminemia
o Wilson disease
Secondary or acquired ones includeo Tyrolean infantile cirrhosis (TIC)
o Indian childhood cirrhosis (ICC)
o Idiopathic copper toxicosis (ICT)
Wilson disease
Wilson disease, or hepatolenticular degeneration, is an autosomal recessive
disorder that results from accumulation of copper predominantly in the liver and
brain. The accumulation is due to defective biliary excretion of copper. Menkes
disease is X linked while Wilson disease is an autosomal recessive disorder. There
are certain facts about this disease
The adult humans need to ingest about 0.75 mg of copper daily to sustain
a balance
Typically, humans ingest about 1 mg of copper per day
The daily excess of copper averaging about 0.25 mg per day is normally
excreted in the feces
Due to a genetic defect, individuals with Wilson disease are unable to
excrete the excess copper, resulting in a cumulative accumulation of
copper in the body (Psora/ Syphilis/ Sycosis)
Clinically symptoms appear in hepatic, neurological, or psychiatric
symptoms, in roughly equal proportions
Neurological
Abnormal walking (Syphilis)
Changes in mood (Psora)
Clumsiness with hands (Psora)
Depression (Psora/ Syphilis)
Drooling (Psora/ Syphilis)
Insomnia (Psora)
Memory, speech, or vision impairment (Psora)
Migraines (Psora)
Personality changes (Psora)
Problems in school (Psora)
Symptoms in advanced pathology
Muscle pain during movement (Psora)
Muscle spasms (Psora)
Seizures (Psora)
Aceruloplasminemia
Aceruloplasminemia is a rare autosomal recessive disorder of iron metabolism
characterized by a defect in the gene coding for ceruloplasmin.
Pathophysiology of aceruloplasminemia
During 1900 and 1980, 138 infants and young children died in the Tyrolean
area of western Austria from liver cirrhosis
This condition was syndrome is called as Tyrolean infantile cirrhosis (TIC)
It is an autosomal recessive disorder (Syphilis)
Probable cause is using unpasteurized cow's milk with water heated for
about 20 min in old copper pots (Causa occasionalis)
Disappeared with the use of modern utensils
Pathophysiology
Treatment
Homoeopathic treatment
Though, the symptoms of copper homeostasis misbalance are quite wide, the
complete repertory may be used. The major signs and symptoms, which
strikingly indicate copper imbalance, can however, be collected and made ready
for emergency reference.
Bibliography
Chapter 130. Cutaneous Changes in Nutritional Disease > Copper and
Menkes Disease Fitzpatrick's Dermatology in General Medicine, 8e
Chapter 37. Inherited Metabolic Diseases of the Nervous System > Menkes
Disease (Kinky- or Steely-Hair Disease; Trichopoliodystrophy, ATP7A Mutation)
Adams & Victor's Principles of Neurology, 10e.... A relationship between Wilson
and Menkes disease is nonetheless evident at a genetic level as they arise from
genes encoding two different copper-transporting proteins that are both ATPases.
The situation, however, may be more complex, as samples of intestinal tissue
show a buildup of copper that indicates...
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Chapter 88. Hair Growth Disorders > Pili Torti and Menkes Syndrome
Fitzpatrick's Dermatology in General Medicine, 8e... or longer broken hairs. Hair
fragility usually improves after puberty. Pili torti occurs in combination with
trichorrhexis nodosa, trichoclasis, and trichoptilosis in Menkes kinky hair
syndrome, also called steely hair syndrome or trichopoliodystrophy. Menkes
syndrome is an X-linked recessive multisystem...
Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver > Wilsons
Disease Harrison's Principles of Internal Medicine ... Wilsons disease is an
inherited disorder of copper homeostasis first described in 1912 ( Chap. 429 ).
The Wilsons disease gene was discovered in 1993, with the identification of
ATP7B . This P-type ATPase is involved in copper transport and is necessary for
the export of copper from...
Nervous System Disorders > 7. Wilson Disease Current Medical Diagnosis &
Treatment 2017... In this metabolic disorder, abnormal movement and posture
may occur with or without coexisting signs of liver involvement. Psychiatric and
neuropsychological manifestations are common. Wilson disease is discussed in
Chapter 16 . ...
Neurologic & Muscular Disorders > 5. Wilson Disease CURRENT Diagnosis &
Treatment Pediatrics, 23e... (See also Chapter 22 .) Wilson disease is a treatable
and reversible genetic disease (AR). Half of patients with Wilson disease present
with or have neuropsychiatric diseases; early symptoms may be as non-specific
as school work deterioration or mild tremor. Wilsons should be ruled out in any...
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