Ethanol (96 Per Cent) (1317)
Ethanol (96 Per Cent) (1317)
Ethanol (96 Per Cent) (1317)
CHARACTERS
Appearance : colourless, clear, volatile, ammable liquid,
hygroscopic.
Solubility : miscible with water and with methylene chloride.
It burns with a blue, smokeless ame.
bp : about 78 C.
IDENTIFICATION
First identification : A, B.
Second identification : A, C, D.
A. Relative density (see Tests).
B. Infrared absorption spectrophotometry (2.2.24).
Comparison : Ph. Eur. reference spectrum of ethanol (96 per
cent).
C. Mix 0.1 mL with 1 mL of a 10 g/L solution of potassium
permanganate R and 0.2 mL of dilute sulfuric acid R in a
test-tube. Cover immediately with a lter paper moistened
with a freshly prepared solution containing 0.1 g of sodium
nitroprusside R and 0.5 g of piperazine hydrate R in 5 mL
of water R. After a few minutes, an intense blue colour
appears on the paper and becomes paler after 10-15 min.
D. To 0.5 mL add 5 mL of water R, 2 mL of dilute sodium
hydroxide solution R, then slowly add 2 mL of 0.05 M
iodine. A yellow precipitate is formed within 30 min.
Column
Time
(min)
0 - 12
Temperature
(C)
40
12 - 32
40 240
32 - 42
240
Injection port
200
Detector
280
4301
Ethanol, anhydrous
K. butan-1-ol (butanol),
L. butan-2-ol,
M. 2-methylpropan-1-ol (isobutanol),
N. furane-2-carbaldehyde (furfural),
STORAGE
Protected from light.
IMPURITIES
P. 2-methylbutan-2-ol,
A. 1,1-diethoxyethane (acetal),
Q. pentan-2-ol,
R. pentan-1-ol (pentanol),
B. acetaldehyde,
S. hexan-1-ol (hexanol),
C. propan-2-one (acetone),
T. heptan-2-ol,
D. benzene,
U. hexan-2-ol,
E. cyclohexane,
V. hexan-3-ol.
01/2015:1318
F. methanol,
ETHANOL, ANHYDROUS(2)
Ethanolum anhydricum
I. propan-1-ol (propanol),
Mr 46.07
DEFINITION
Content : not less than 99.5 per cent V/V of C2H6O (99.2 per
cent m/m), at 20 C, calculated from the relative density using
the alcoholimetric tables (5.5).
(2) This monograph has undergone pharmacopoeial harmonisation. See chapter 5.8. Pharmacopoeial harmonisation.
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