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Mitral Valve Disease

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Mitral valve disease

Mitral regurgitation Assessment/diagnosis:


Pathophysiology:  Echocardiography (TTE)
 Backflow of blood from the LV to the LA during systole  ECG (look for Afib, signs of LVH)
 Mild mitral regurgitation is seen in 80% of normal people  Chest X-ray (look for enlarged heart, aortic dissection,
rule out pulmonary oedema)
Causes:
 Myxomatous degeneration  mitral valve prolapse Management:
 Chronic myocardial disease (IHD, DCM)  mitral annulus  Heart failure therapies:
dilatation o Diuretics
 Ischemia/acute MI  rupture of papillary muscle o Ace-inhibitors
 Endocarditis  destruction of leaflets o Beta blockers
 Rheumatic heart disease (most common in developing  Catheter-based interventions:
world)  chordae tendinae rupture o Clips/rings
 Secondary cause: dilatation of LV due to congestive heart  Surgical replacement
failure
 Essentially, a problem with the annulus, leaflets, chordae,
papillary muscle, or LV can cause mitral regurgitation

Clinical features:
 Breathlessness (due to pulmonary hypertension)
 Exertional dyspnoea
 Palpitations/Afib
 Sometimes can be asymptomatic
 Soft pan-systolic murmur with soft S1
 Acute MR:
o Can occur secondary to trauma, ischemia,
spontaneous rupture
o Causes acute onset SOB
o Require urgent surgery (usually MVR)

Mitral stenosis Assessment/diagnosis:


Pathophysiology:  Echocardiography (TTE)
 Obstruction of LV inflow  impairment of proper filling  ECG
during diastole  atrial dilatation  Chest X-ray
 Pulmonary venous congestion/pulmonary hypertension will
occur  right heart failure Management:
 Heart failure therapies:
Caused by: o Diuretics
 Rheumatic fever o Ace-inhibitors
 Mitral annular and subvalvar calcification o Beta blockers
 Infective endocarditis  Catheter-based interventions:
 Autoimmune disease: SLE, RA o Percutaneous ballon mitral valvuloplasty (PBMV)
o Clips/rings
Clinical features:  Surgical replacement
 Exertional dyspnoea 
 Orthopnoea, paroxysmal nocturnal dyspnoea (from
pulmonary hypertension)
 Diastolic murmur at apex
 Loud opening snap at apex
 Mitral facies/malar flush  vasoconstriction/hypoxia from
low cardiac output

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