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0002 CHAPTER 21 GENERAL ANESTHETICS Goodman and Gilman The Pharmacological 13th - 4

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











 
  
   
   
 


  
   
   
 
  
  


 







          






        

    


  
 
       
 


 
 
 





 
 
 

 

 

           
 
 
 


 
      
  


 

 

 

  
 
 
 
 

 
 
 
 
 

 
 
 
  
 
  
  
 

         

   

           


 

 
  





 

 


 

       
        




      
 
 
         

 
  
 
 
   
           


 

 








 
  
           
      
 


 





         

  

 

  


        
 
 
            

  
 

 
       
 

 
  





 

 

 
 
        


 
       
      
   

 
 
 
 



   
         
       
       
       
      
       
 



 
 
 
 
       
           

     

 

 

         
 
   
 








 

 
 
       
 
        
    
 
 
 



    
          
 



   
     
        
        
        
       

  
   
  

  
  
  
 
   

   

   

 


         








           









         
 
 


         

 


    
 
 
 

 
 
         










 
 
 



 
 
        
 
  
 
 

 
 
 
 
 
 

  
 

         
        
 
 
        
 

 
      
 
 
      

 

 

 



 
       
 
 
 
 

 
 
    
          
 
 

         
  
 
 
 

           
 
 






   

  




 

 


           

    
         
 
 
 
 
 
  
     
       
 
 
  

 
      
     
 
  


 



 
             
 


 


 







 
         
 






  



         
 
 


  
 
 



 
        
     

      
      
      
      
       
       







   
 



 



 

  




  
 

   
     

 
 
        

            







  

 
 
 

 

 






 
 

 
 









 

 
  
 
 

 


        
 





  



  
         

 



 
   
  






   



   


 

 
  
 

   


 
 

  

 





 

 



         


 

  



 
 


 


 
 
 
 
 


    
 
         
 
  
 
      

 

           
          

  
 

 

 

 
 
 
 
 
 
 

 

 

  


 









      

 
















 

  





 

 
         

 
 
 
 

 
 
 
 

 

 
  

  
      
     
 
        
     
  
 
 
 




  
   

 
 



 
           
  
 
 
            

 
 
  
 
  
          

 
   
 


  
 
 
 
 
  
       
        

  



 
 





  
  
 
 

 
 

        
              
 
  
  
  







 


  

 






   


   

  
 
  

   
    
           

   
 
 

 
  


      
   

  
 
 

  


 
 
  

 
    
         
        

        
        
        
         



 


 

 
  
         
  
 

  
         
 
 
         
          
  


 

   
 
 

 


  
 
  
 

 

 



 

  

 
 

  
  
        
 
 
 
 
 

 

 

  
         

 
 

  



 
         
         

 
 
 
  
 
 
  

 
 
         
         

       
       
 
 
 
  
 


 

 

 


        
 
 
 

 
 
 
        
  
           
 


 
 
 
 
         


  
   


 
  
   
             
  
          
 
 

 
 
  
 
 
 
   
 

  
 

  
 
   
             
  
 
  
 


 
           

 
 
 
 





 
        
 
 
         


 


 
 
         


 
 
             


 
 
     
 
 



      
 
  
 
 
       
         
 
       

 


        


 
 

  


     
 
 



 

 
  
  
 

 












 


 






 


 








 







 
 



 
 
 






 

  


 










  




 


 

  
 

 






 






         
         
 
 
 
                   
 
        
  
         
 

 
 
 
 
         
 
         
 

      
 
  
 
          
 
 
 
 
          
 
                    
 
 

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