Cholinergics and Cholinergic Blockers
Cholinergics and Cholinergic Blockers
Cholinergics and Cholinergic Blockers
I. Cholinergics / Parasympathomimetics
• mimics effects of acetylcholine, stimulating PSNS
B. Inactivation of Acetylcholine
• Acetylcholinesterase
MOA: acts on muscarinic receptors to increase urination, constrict pupils & reduce
Intraocular pressure, increase GI peristalsis
MOA: blocks AChE and cross blood brain barrier thus improving memory by
increasing Ach in the brain
MOA: blocks AChE, thus increasing Ach at synaptic cleft and cause increase in
muscle strength & tone.
Indications: antispasmodic in the Tx of peptic ulcer disease (PUD) & irritable bowel
Syndrome (IBS)
Atropine
Indications:
1. preop med to decrease salivary & respiratory secretions
2. tx PUD by decreasing GI spasms & peristalsis
3. tx sinus bradycardia by increasing HR
4. antidote for cholinergic drug overdose
5. mydriatic agent
MOA: blocks Ach by occupying muscarinic receptors causing:
• increase HR by blocking vagus stimulation
• pupil dilation by paralyzing iris sphincter
• decrease secretions & GI motility
Blind as a bat.
Red as a beet
Mad as a hatter.
Hot as a hare.
Dry as a bone.
MOA: block effects of Ach thus reducing tremors & rigidity, & decreasing
salivation in parkinson’s & pseudoparkinsonism