Diagnostic Report: Final
Diagnostic Report: Final
Diagnostic Report: Final
Interpretation(s)
ANTI - CCP ANTIBODIES, SERUM-Rheumatoid arthritis (RA) is a systematic autoimmune disease that is multi-functional in origin and is characterized by chronic
inflammation of the membrane lining(synovium) joints which commonly leads to progressive joint destruction and in most cases to disability and reduction of quality of life..
The disease spreads from small to large joints, with the greatest damage in early phase.
The diagnosis of RA is primarily based on clinical, radiological and immunological features. The most frequent serological test is the measurement of rheumatoid factor (RF).
The IgM class is the most common and is found in 60-80% of RA patients. RF is not specific for RA, as it is often present in healthy individuals and patients with other
autoimmune diseases and chronic infections. Citrullinated proteins have been discovered in the joints of patients with rheumatoid arthritis but not in other forms of joint
disease. The citrullinated proteins in the joints correspond to the presence of the citrulline antibodies in the blood and suggest a possible role for these antibodies in the
development of rheumatoid arthritis. Anti-CCP test is used for the detection of the IgG class of autoantibodies specific to cyclic citrullinated peptide (CCP) in human serum or
plasma (EDTA). Autoantibody levels represent one parameter in a multi-criterion diagnosis process, encompassing both clinical and laboratory-based assessments.
The citrulline antibody appears early in the course of rheumatoid arthritis and is present in the blood of most patients with the disease. When the citrulline antibody is
detected in a patient''s blood, there is 90-95% likelihood that the patient has rheumatoid arthritis. The test for the citrulline antibody is therefore useful in the diagnosis of
patients with unexplained joint inflammation, especially when the traditional blood test for rheumatoid factor is negative. The citrulline antibody also has prognostic
(predictive) value since it is associated with a greater tendency towards more destructive forms of rheumatoid arthritis.
Detection of anti -CCP antibodies is used as an aid in the diagnosis of Rheumatoid arthritis(RA) and should be used in conjunction with other clinical information.
AUTOIMMUNE IFA
ABS TO EXTRACTABLE NUCLEAR ANTIGEN(ANA BLOT),SERUM
Page 1 Of 2
Comments
If the ANA IFA is POSITIVE and the ANA Immunoblot specific antibody test(s) are negative, it may be due to presence of other autoantibodies and
disease association which is not included in this antibody profile. When the clinical finding suggests a specific autoimmune disorder, it is
recommended to perform a follow-up test for those antibodies, if commercially available or further Renal Biopsy IFA testing may be considered.
Advised to correlate ancillary investigations and clinical findings.
**End Of Report**
Please visit www.srlworld.com for related Test Information for this accession
Dr.C.N.Srinivas
Vice President – Technical &
Head of HLA & TI
Page 2 Of 2