Report
Report
Report
CID : 2333623093
Name : MS.SAYLI NARALE
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Age / Gender : 25 Years / Female Application To Scan the Code
Reflex Tests:
1. HBV DNA
2. Anti HBcIgM
3. HBeAg and Anti HBe
Limitations of the test:
Heterophile antibodies in human serum can react with reagent immunoglobulins, interfering with in vitro immunoassays.
Patients routinely exposed to animals or animal serum products can be prone to this interference.
Reference:
HBsAg (Generation II) kit pack insert
Bakerman's ABC's of Interpretive Laboratory Data
Wallach's Interpretation of Diagnostic Tests
Henry's Clinical Diagnosis and Management by Laboratory methods
*Sample processed at SUBURBAN DIAGNOSTICS (INDIA) PVT. LTD SDRL, Vidyavihar Lab
*** End Of Report ***
Dr.SUHAS SAKHARE
M.D. (PATH)
Pathologist
Page 1 of 1
Ms. SAYLI N RALE Reference: DR.APARNA PATIL VID: 230067502234089
.. Sample Collected At: Registered On:
Sanjay Arora Dr.-andheri-20
03/12/2023 02:24 PM
Suburban Diag.[i] Pvt. Ltd. 2nd Floor
PID NO: P10423514870752 Sunshine Opp.shastri Nagar Andheri Collected On:
Age: 25 Year(s) Sex: Female WZone: W-16a(20) 03/12/2023 2:23PM
Processing Location:- Metropolis Reported On:
Healthcare Ltd,Unit No409-416,4th
Floor,Commercial Building-1,Kohinoor 06/12/2023 04:44 PM
Mall,Mumbai-70
Interpretation:
1. TPMT enzyme levels below 5.5 Units indicate very low TMPT activity,indicating a possible homozygous deficiency genomic
type.
2. Levels between 5.6 - 15.5 units indicate medium TPMT activity indicating possible heterozygous deficiency type.
3. Level above 15.6 Units indicate normal to high TPMT activity,indicating a possible wilde (normal) genomic type. Thiopurine
drugs exhibit severe toxicity mainly the gastrointestinal intolerance,Cytopenia or bone marrow suppression which is usually
life Threatening. These drugs require conversion to thioguanine nucleotides to exert their therapeutic (cytotoxic) effect ;
however , the conversion can be blocked by methylation or oxidation. The methylation pathway depends on thiopurine
methyltransferase ( TPMT ) activity.
4. The TPMT enzyme catalysis the S-methylation of thiopurine drugs.
TPMT activity varies among individuals:
Approximately 89% have normal activity,11% Have intermediate activity, and 0.3% have low or no detectable activity.Thioguanine
Nucleotides can accumulate in patients who have reduced TPMT activity and who are Receiving standard thiopurine doses,
resulting in hematopoietic toxicity (e.g., myelosuppression). Dosage reduction can minimize toxicity in such patients, Phenotypic test
utilizes competitive immunoassay for semi quantitative determination of TPMT activity in erythrocytes. One unit of TPMT is defined
as a formation of 1 nmol Of 6-MMP per ml of packed red blood cells per 60 mins at 37°.
-- End of Report --
Tests marked with NABL symbol are accredited by NABL vide Certificate no MC-2139; Validity till 01-06-2024
Page 1 of 1
Dr. ALAP CHRISTY
MBBS, MD, PGDM-HC Head -
Clinical Chemistry
Reg No.2020/12/6991
Name : Ms. SAYLI NARALE Age : 25 Years
Lab No. : 456657702 Gender : Female
Ref By : Dr. APARNA PATIL Reported : 5/12/2023 5:58:35PM
Collected : 3/12/2023 12:33:00PM Report Status : Final
A/c Status : P
Collected at : SUBURBAN DIAGNOSTICS ANDHERI WEST Processed at : LPL-NATIONAL REFERENCE LAB
1st Floor & Shop no 9, C-Wing, Skyline Wealth National Reference laboratory, Block E,
Space, Skyline Oasis, Primier Road, Vidhyavihar Sector 18, Rohini, New Delhi -110085
W, Mumbai-400086, Near D-Mart.
Test Report
Titer 1:10
Page 1 of 5
Name : Ms. SAYLI NARALE
Lab No. : 456657702 Age : 25 Years
Ref By : Dr. APARNA PATIL Gender : Female
Collected : 3/12/2023 12:33:00PM Reported : 5/12/2023 5:58:35PM
A/c Status : P Report Status : Final
Collected at : SUBURBAN DIAGNOSTICS ANDHERI WEST Processed at : LPL-NATIONAL REFERENCE LAB
1st Floor & Shop no 9, C-Wing, Skyline Wealth National Reference laboratory, Block E,
Space, Skyline Oasis, Primier Road, Vidhyavihar Sector 18, Rohini, New Delhi -110085
W, Mumbai-400086, Near D-Mart.
Test Report
Interpretation
| TUBE | REMARKS |
|-----------------------|----------------------------------------------------------------|
| Nil | Represents negative control which rules out the preexisting |
| | immune response due to heterophile antibody or non-specific |
| | gamma interferon production. |
|-----------------------|----------------------------------------------------------------|
| Mitogen minus Nil | Represents positive control demonstrating successful |
| | lymphocyte activity. |
|-----------------------|----------------------------------------------------------------|
| CMV Antigen minus Nil | Detects CD8+ lymphocyte reactivity, stimulated by CMV antigens.|
Result
| RESULT | REMARKS |
|---------------|----------------------------------------------------------------------|
| | Indicates presence of IFN-Gamma response to CMV antigens. It helps in|
| | dpredicting the risk of new and recurrent CMV disease following |
| Positive | transplantation (solid organ & haematological), guides in therapeutic|
| | decision making regarding prophylaxis and preemptive therapies, risk |
| | risk stratification of patients before transplantation and improving |
| | patient health. |
|---------------|----------------------------------------------------------------------|
| | Indicates absence of IFN-Gamma response to CMV antigens in patient’s |
| Negative | sample but does not exclude the possibility of CMV disease. Such |
| | patients undergoing Solid organ transplant are vulnerable to develop |
| | CMV infection |
|---------------|----------------------------------------------------------------------|
| Indeterminate | Indicates that IFN-Gamma Response to CMV antigens and Mitogen cannot |
| | be detected and may be related to the immune status of the individual|
Note
1. CMV serology is widely used pre-transplantation to establish risk of CMV complications post
Page 2 of 5
Name : Ms. SAYLI NARALE
Lab No. : 456657702 Age : 25 Years
Ref By : Dr. APARNA PATIL Gender : Female
Collected : 3/12/2023 12:33:00PM Reported : 5/12/2023 5:58:35PM
A/c Status : P Report Status : Final
Collected at : SUBURBAN DIAGNOSTICS ANDHERI WEST Processed at : LPL-NATIONAL REFERENCE LAB
1st Floor & Shop no 9, C-Wing, Skyline Wealth National Reference laboratory, Block E,
Space, Skyline Oasis, Primier Road, Vidhyavihar Sector 18, Rohini, New Delhi -110085
W, Mumbai-400086, Near D-Mart.
Test Report
Comment
Human Cytomegalovirus (CMV) represents one of the primary opportunistic pathogens and is a leading
cause of morbidity and mortality in Solid organ transplant recipients. It is a frequently occurring complication
of immunosuppression, particularly after transplantation. Pre-emptive or prophylactic antiviral therapy has
effectively reduced the impact and incidence of symptomatic CMV infection. Cell-mediated immunity (CMI),
and specifically CMV-specific CD4+ and CD8+ T-cell response, is able to control viral replication and thus
the onset of symptomatic infections.
CMV-IGRA in combination with quantitative monitoring of viral load in blood is recommended in CMV
Consensus Guidelines on the management of CMV in solid organ transplant patients. Transplant recipient
patients who have low or declining viral load in presence of positive CMV-IGRA may indicate a low risk of
disease and possible opportunity to stop antiviral therapy and adjust immunosuppressive treatment. On the
other hand transplant recipient patients who have high or increasing viral load in presence of negative
CMV-IGRA may indicate a high risk of CMV complications and the need to start or continue antiviral therapy,
begin cellular adoptive immunotherapy and adjust the immunosuppressive drugs.
In hematopoietic stem cell transplantation (HSCT), reactivation of latent virus is more common than
acquisition of primary infection. Preventing reactivation requires a robust T cell mediated immune reponse.
Immunosuppression and T cell depleting protocols used pre-HSCT, affect the risk of reactivation.
HLA-mismatched transplants where immunosuppression is increased and GVHD is more likely, are
Page 3 of 5
Name : Ms. SAYLI NARALE
Lab No. : 456657702 Age : 25 Years
Ref By : Dr. APARNA PATIL Gender : Female
Collected : 3/12/2023 12:33:00PM Reported : 5/12/2023 5:58:35PM
A/c Status : P Report Status : Final
Collected at : SUBURBAN DIAGNOSTICS ANDHERI WEST Processed at : LPL-NATIONAL REFERENCE LAB
1st Floor & Shop no 9, C-Wing, Skyline Wealth National Reference laboratory, Block E,
Space, Skyline Oasis, Primier Road, Vidhyavihar Sector 18, Rohini, New Delhi -110085
W, Mumbai-400086, Near D-Mart.
Test Report
Dr Sunanda
MD, Pathology
Sr. Consultant Pathologist -
Hematology & Immunology
NRL - Dr Lal PathLabs Ltd
Page 4 of 5
Name : Ms. SAYLI NARALE
Lab No. : 456657702 Age : 25 Years
Ref By : Dr. APARNA PATIL Gender : Female
Collected : 3/12/2023 12:33:00PM Reported : 5/12/2023 5:58:35PM
A/c Status : P Report Status : Final
Collected at : SUBURBAN DIAGNOSTICS ANDHERI WEST Processed at : LPL-NATIONAL REFERENCE LAB
1st Floor & Shop no 9, C-Wing, Skyline Wealth National Reference laboratory, Block E,
Space, Skyline Oasis, Primier Road, Vidhyavihar Sector 18, Rohini, New Delhi -110085
W, Mumbai-400086, Near D-Mart.
Test Report
Page 5 of 5
.
Test Report
Titer 1:10
*456657702*
Page 1 of 5
.
Test Report
Interpretation
---------------------------------------------------------------------------------------
| TUBE | REMARKS |
|-----------------------|----------------------------------------------------------------|
| Nil | Represents negative control which rules out the preexisting |
| | immune response due to heterophile antibody or non-specific |
| | gamma interferon production. |
|-----------------------|----------------------------------------------------------------|
| Mitogen minus Nil | Represents positive control demonstrating successful |
| | lymphocyte activity. |
|-----------------------|----------------------------------------------------------------|
| CMV Antigen minus Nil | Detects CD8+ lymphocyte reactivity, stimulated by CMV antigens.|
----------------------------------------------------------------------------------------
Result
--------------------------------------------------------------------------------------
| RESULT | REMARKS |
|---------------|----------------------------------------------------------------------|
| | Indicates presence of IFN-Gamma response to CMV antigens. It helps in|
| | dpredicting the risk of new and recurrent CMV disease following |
| Positive | transplantation (solid organ & haematological), guides in therapeutic|
| | decision making regarding prophylaxis and preemptive therapies, risk |
| | risk stratification of patients before transplantation and improving |
| | patient health. |
|---------------|----------------------------------------------------------------------|
| | Indicates absence of IFN-Gamma response to CMV antigens in patient’s |
| Negative | sample but does not exclude the possibility of CMV disease. Such |
| | patients undergoing Solid organ transplant are vulnerable to develop |
| | CMV infection |
|---------------|----------------------------------------------------------------------|
| Indeterminate | Indicates that IFN-Gamma Response to CMV antigens and Mitogen cannot |
| | be detected and may be related to the immune status of the individual|
--------------------------------------------------------------------------------------
Note
1. CMV serology is widely used pre-transplantation to establish risk of CMV complications post
PatientReportSCSuperPanel.SP_GENERAL_TEMPLATE01_SC (Version: 7)
*456657702*
Page 2 of 5
.
Test Report
Comment
Human Cytomegalovirus (CMV) represents one of the primary opportunistic pathogens and is a leading
cause of morbidity and mortality in Solid organ transplant recipients. It is a frequently occurring complication
of immunosuppression, particularly after transplantation. Pre-emptive or prophylactic antiviral therapy has
effectively reduced the impact and incidence of symptomatic CMV infection. Cell-mediated immunity (CMI),
and specifically CMV-specific CD4+ and CD8+ T-cell response, is able to control viral replication and thus
the onset of symptomatic infections.
CMV-IGRA in combination with quantitative monitoring of viral load in blood is recommended in CMV
Consensus Guidelines on the management of CMV in solid organ transplant patients. Transplant recipient
patients who have low or declining viral load in presence of positive CMV-IGRA may indicate a low risk of
disease and possible opportunity to stop antiviral therapy and adjust immunosuppressive treatment. On the
other hand transplant recipient patients who have high or increasing viral load in presence of negative
CMV-IGRA may indicate a high risk of CMV complications and the need to start or continue antiviral therapy,
begin cellular adoptive immunotherapy and adjust the immunosuppressive drugs.
In hematopoietic stem cell transplantation (HSCT), reactivation of latent virus is more common than
acquisition of primary infection. Preventing reactivation requires a robust T cell mediated immune reponse.
Immunosuppression and T cell depleting protocols used pre-HSCT, affect the risk of reactivation.
HLA-mismatched transplants where immunosuppression is increased and GVHD is more likely, are
PatientReportSCSuperPanel.SP_GENERAL_TEMPLATE01_SC (Version: 7)
*456657702*
Page 3 of 5
.
Test Report
Dr Sunanda
MD, Pathology
Sr. Consultant Pathologist -
Hematology & Immunology
NRL - Dr Lal PathLabs Ltd
PatientReportSCSuperPanel.SP_GENERAL_TEMPLATE01_SC (Version: 7)
*456657702*
Page 4 of 5
.
Test Report
PatientReportSCSuperPanel.SP_GENERAL_TEMPLATE01_SC (Version: 7)
*456657702*
Page 5 of 5