SAFETY DATA SHEET Version 6.

3
Revision Date 17.10.2019
according to Regulation (EC) No. 1907/2006 Print Date 07.10.2020
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : Benzalkonium chloride
Product Number : 12060
Brand : Sigma-Aldrich
Index-No. : 612-140-00-5
REACH No. : A registration number is not available for this substance as the
substance or its uses are exempted from registration, the
annual tonnage does not require a registration or the
registration is envisaged for a later registration deadline.
CAS-No. : 63449-41-2
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Chemie BV
Stationsplein 4
3331 LL ZWIJNDRECHT
NETHERLANDS
Telephone : +31 078 620-5411
Fax : +31 078 620-5421
E-mail address : technischeservicebenelux@merckgroup.com
1.4 Emergency telephone number
Emergency Phone # : +(31)-858880596 (CHEMTREC)
112 (Alarmnummer)

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), H302
Acute toxicity, Dermal (Category 4), H312
Skin corrosion (Sub-category 1B), H314
Short-term (acute) aquatic hazard (Category 1), H400
For the full text of the H-Statements mentioned in this Section, see Section 16.

Sigma-Aldrich- 12060 Page 1 of 9

The life science business of Merck operates as MilliporeSigma in

the US and Canada
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram

Signal word Danger

Hazard statement(s)
H302 + H312 Harmful if swallowed or in contact with skin.
H314 Causes severe skin burns and eye damage.
H400 Very toxic to aquatic life.
Precautionary statement(s)
P260 Do not breathe dust or mist.
P273 Avoid release to the environment.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
Supplemental Hazard none
Statements
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances
Synonyms : Alkyldimethylbenzylammonium chloride
Alkylbenzyldimethylammonium chloride

CAS-No. : 63449-41-2
EC-No. : 264-151-6
Index-No. : 612-140-00-5
Component Classification Concentration
Benzalkonium chloride
Acute Tox. 4; Skin Corr. <= 100 %
1B; Aquatic Acute 1;
H302, H312, H314, H400
For the full text of the H-Statements mentioned in this Section, see Section 16.

Sigma-Aldrich- 12060 Page 2 of 9

The life science business of Merck operates as MilliporeSigma in

the US and Canada
SECTION 4: First aid measures
4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of
water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse
mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Nature of decomposition products not known.
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
No data available

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist
or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing
dust.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Discharge into the environment must be avoided.

Sigma-Aldrich- 12060 Page 3 of 9

The life science business of Merck operates as MilliporeSigma in

the US and Canada
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in
suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
hygroscopic Store under inert gas.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters
Components with workplace control parameters
8.2 Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands
before breaks and at the end of workday.
Personal protective equipment

Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and
approved under appropriate government standards such as NIOSH (US) or EN
166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact
with this product. Dispose of contaminated gloves after use in accordance with
applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU)
2016/425 and the standard EN 374 derived from it.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm

Sigma-Aldrich- 12060 Page 4 of 9

The life science business of Merck operates as MilliporeSigma in

the US and Canada
 Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail
sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which
differ from EN 374, contact the supplier of the CE approved gloves. This
recommendation is advisory only and must be evaluated by an industrial hygienist
and safety officer familiar with the specific situation of anticipated use by our
customers. It should not be construed as offering an approval for any specific use
scenario.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must
be selected according to the concentration and amount of the dangerous substance
at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-
face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as
a backup to engineering controls. If the respirator is the sole means of protection,
use a full-face supplied air respirator. Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US) or CEN
(EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Appearance Form: Semi-solid melting to a liquid
Colour: light yellow
b) Odour No data available
c) Odour Threshold No data available
d) pH No data available
e) Melting No data available
point/freezing point
f) Initial boiling point No data available
and boiling range
g) Flash point No data available
h) Evaporation rate No data available
i) Flammability (solid, No data available
gas)
j) Upper/lower No data available
flammability or
explosive limits
k) Vapour pressure No data available
l) Vapour density No data available

Sigma-Aldrich- 12060 Page 5 of 9

The life science business of Merck operates as MilliporeSigma in

the US and Canada
 m) Relative density No data available
n) Water solubility No data available
o) Partition coefficient: No data available
n-octanol/water
p) Auto-ignition No data available
temperature
q) Decomposition No data available
temperature
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
No data available

SECTION 10: Stability and reactivity

10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
Avoid moisture.
10.5 Incompatible materials
Strong oxidizing agents
10.6 Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Nature of decomposition
products not known.
Other decomposition products - No data available
In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects
Acute toxicity
No data available
LD50 Dermal - Rat - 1.420 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity). Blood: Hemorrhage.
Skin corrosion/irritation
No data available
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitisation
No data available

Sigma-Aldrich- 12060 Page 6 of 9

The life science business of Merck operates as MilliporeSigma in

the US and Canada
 Germ cell mutagenicity
No data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Additional Information
RTECS: BO3151000

Cough, Shortness of breath, Headache, Nausea, Vomiting

To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.

SECTION 12: Ecological information

12.1 Toxicity
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Other adverse effects
Very toxic to aquatic life.

SECTION 13: Disposal considerations

13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or
mix the material with a combustible solvent and burn in a chemical incinerator equipped
with an afterburner and scrubber. Waste material must be disposed of in accordance with
the Directive on waste 2008/98/EC as well as other national and local regulations. Leave

Sigma-Aldrich- 12060 Page 7 of 9

The life science business of Merck operates as MilliporeSigma in

the US and Canada
 chemicals in original containers. No mixing with other waste. Handle uncleaned containers
like the product itself.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information

14.1 UN number
ADR/RID: 3261 IMDG: 3261 IATA: 3261
14.2 UN proper shipping name
ADR/RID: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. (Benzalkonium chloride)
IMDG: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. (Benzalkonium chloride)
IATA: Corrosive solid, acidic, organic, n.o.s. (Benzalkonium chloride)
14.3 Transport hazard class(es)
ADR/RID: 8 IMDG: 8 IATA: 8
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: yes IMDG Marine pollutant: yes IATA: no
14.6 Special precautions for user
No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment

For this product a chemical safety assessment was not carried out

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
H302 Harmful if swallowed.
H302 + H312 Harmful if swallowed or in contact with skin.
H312 Harmful in contact with skin.
H314 Causes severe skin burns and eye damage.
H400 Very toxic to aquatic life.
Further information
Copyright 2018 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies
for internal use only.
The above information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide. The information in this document is based on the
present state of our knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any guarantee of the properties of

Sigma-Aldrich- 12060 Page 8 of 9

The life science business of Merck operates as MilliporeSigma in

the US and Canada
 the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any
damage resulting from handling or from contact with the above product. See
www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional
terms and conditions of sale.

The branding on the header and/or footer of this document may temporarily not visually
match the product purchased as we transition our branding. However, all of the
information in the document regarding the product remains unchanged and matches the
product ordered. For further information please contact mlsbranding@sial.com.

Sigma-Aldrich- 12060 Page 9 of 9

The life science business of Merck operates as MilliporeSigma in

the US and Canada