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    Drug Name Mechanism of Action Indication/Contraindication Adverse Effect Nursing Responsibilities: Generic

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    Arian May Marcos
    Methyldopa works by inhibiting the production of dopamine and norepinephrine, reducing blood pressure. It is used to treat hypertension, especially in patients with kidney disease. Common side effects include sedation, dizziness, diarrhea, and positive Coombs' test results. Nurses should monitor for signs of liver problems and advise patients of drug and food interactions.

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    Drug Name Mechanism of Action Indication/Contraindication Adverse Effect Nursing Responsibilities: Generic

    Uploaded by

    Arian May Marcos
    652 views2 pages
    Methyldopa works by inhibiting the production of dopamine and norepinephrine, reducing blood pressure. It is used to treat hypertension, especially in patients with kidney disease. Common side effects include sedation, dizziness, diarrhea, and positive Coombs' test results. Nurses should monitor for signs of liver problems and advise patients of drug and food interactions.

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    METHYLDOPA DS

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    Methyldopa works by inhibiting the production of dopamine and norepinephrine, reducing blood pressure. It is used to treat hypertension, especially in patients with kidney disease. Common side effects include sedation, dizziness, diarrhea, and positive Coombs' test results. Nurses should monitor for signs of liver problems and advise patients of drug and food interactions.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    652 views2 pages

    Drug Name Mechanism of Action Indication/Contraindication Adverse Effect Nursing Responsibilities: Generic

    Uploaded by

    Arian May Marcos
    Methyldopa works by inhibiting the production of dopamine and norepinephrine, reducing blood pressure. It is used to treat hypertension, especially in patients with kidney disease. Common side effects include sedation, dizziness, diarrhea, and positive Coombs' test results. Nurses should monitor for signs of liver problems and advise patients of drug and food interactions.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
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    DRUG NAME MECHANISM OF ACTION INDICATION/CONTRAINDICATION ADVERSE EFFECT NURSING

    RESPONSIBILITIES:

    GENERIC: Structurally related to I. INDICATION: Treatment of sustained Body as a Whole:


    METHYLDOPA catecholamines and their moderate to severe hypertension, Hypersensitivity (Fever, skin
    precursors. Has weak particularly in patients with kidney eruptions, ulcerations of soles
    BRAND: Aldomet, neurotransmitter properties; dysfunction. Also used in selected patients of feet, flu-like symptoms,
    Apo-Methyldopa , inhibits decarboxylation of with carcinoid disease. Parenteral form has lymphadenopathy,
    Dopamet , dopa, thereby reducing been used for treatment of hypertensive eosinophilia). CNS: Sedation,
    Novomedopa concentration of dopamine, a crises but is not preferred because of its drowsiness, sluggishness,
    precursor of norepinephrine. It slow onset of action. headache, weakness, fatigue,
    CLASS:
    also inhibits the precursor of dizziness, vertigo, decrease in
    CARDIOVASCULAR
    serotonin. mental acuity, inability to
    AGENT; CENTRAL-
    concentrate, amnesia-like
    ACTING, CONTRAINDICATION: ALDOMET
    syndrome, parkinsonism, mild
    ANTIHYPERTENSIV (methyldopa) is contraindicated in patients:
    psychoses, depression,
    E; AUTONOMIC Methyldopa may lower blood
    nightmares. CV: Orthostatic
    NERVOUS SYSTEM pressure by stimulating central
    hypotension, syncope,
    AGENT; ALPHA- inhibitory alpha-adrenergic
    — with active hepatic disease, such as bradycardia, myocarditis,
    ADRENERGIC receptors, false
    acute hepatitis and active cirrhosis edema, weight gain (sodium
    AGONIST neurotransmission, and/or
    and water retention),
    (SYMPATHOMIMETI reduction of plasma renin
    paradoxic hypertensive
    C) activity.
    reaction (especially with IV
    — with liver disorders previously
    administration). GI: Diarrhea,
    associated with methyldopa therapy (see
    constipation, abdominal
    WARNINGS) † with hypersensitivity to
    THERAPEUTIC: distension, malabsorption
    any component of these products.
    Lowers standing and syndrome, nausea, vomiting,
    supine BP, and unlike dry mouth, sore or black
    adrenergic blockers, is tongue, sialadenitis, abnormal
    not so prone to produce — on therapy with monoamine oxidase liver function tests, jaundice,
    orthostatic hypotension, (MAO) inhibitors. hepatitis, hepatic necrosis
    diurnal BP variations, (rare). Hematologic: Positive
    or exercise DRUG TO DRUG INTERACTION: direct Coombs' test (common
    hypertension. Reduces Decreased absorption with colestyramine. especially in African-
    renal vascular Decreased serum concentrations with Americans), granulocytopenia.
    resistance; maintains rifampicin and some anticonvulsants (e.g. Special Senses: Nasal
    cardiac output without phenytoin, phenobarbital, carbamazepine, stuffiness. Endocrine:
    acceleration, but may primidone). Enhances the anticoagulant Gynecomastia, lactation,
    slow heart rate; tends to effect of warfarin and other coumarins with decreased libido, impotence,
    support sodium and prolonged use. Increased absorption with hypothermia (large doses),
    water retention. metoclopramide and domperidone. positive tests for lupus and
    Increased serum concentration with rheumatoid factors. Skin:
    DOSAGE: probenecid. May increase serum Granulomatous skin lesions.
    concentration of chloramphenicol.
    Adult: PO 250 mg
    b.i.d. or t.i.d., may be DRUG TO FOOD INTERACTION:
    increased up to 3 g/d in Increased risk of hepatotoxicity with
    divided doses IV 250– alcohol. Decreased serum concentration
    500 mg q6h, may be with St John’s wort.
    increased up to 1 g q6h

    Geriatric: PO 125 mg
    b.i.d. or t.i.d., may
    increase gradually
    (max: 3 g/d)

    Child: PO 10–65
    mg/kg/d in 2–4 divided
    doses (max: 3 g/d) IV
    20–65 mg/kg/d in 4
    divided doses

    ROUTE: Oral, IV

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