Pcol QS
Pcol QS
Pcol QS
Neither Cefotetan
cefdinir Ertapenem
cefoxitin Imipenem
1 points Meropenem
QUESTION 13 1 points
1. Which has activity against anaerobes
QUESTION 19
Cefofetan
1. This may cause allergic pneumonitis in
Cefaclor prolonged treatment:
Bacitracin
Cefuroxime
Cycloserine
Cefprozil
*Cefoxitin & Cefotetan - have activity Fosfomycin
against anaerobes
Daptomycin
1 points 1 points
QUESTION 14 QUESTION 20
1. Which cephalosporin is excreted mainly thru the 1. This is cell wall synthesis inhibitor is produced
urine? by Streptomyces roseosporus
Cefotaxime Cycloserine
Ceftriaxone Bacitracin
both Daptomycin
neither Vancomycin
1 points Fosfomycin
QUESTION 15
1 points
1. Which can be used to treat pneumococcal
meningitis QUESTION 21
Ceftriaxone 1. Cephalosporins has activity against:
Streptococci
Cefoxitin
MRSA
both
both
neither
neither
1 points
1 points
QUESTION 16
1. Which can be used to treat carbapenemase- QUESTION 22
producing bacteria 1. Oxacillin is active against
Ceftolozane-tazobactam Gram negatives
Ceftazidime-avibactam anaerobes
both both
neither Neither
*little to no activity against Gr(-),
1 points Enterococci and anaerobic
QUESTION 17 1 points
1. Which can be used to treat metallo-beta- QUESTION 23
lactamase producing bacteria 1. Resistance mechanism to penicillin:
Ceftolozane-tazobactam Inhibition of Beta-lactamase
Ceftazidime-avibactam Production of efflux pump
both both
neither Neither
*Beta-lactamase PRODUCTION is the
1 points most common mechanism of resistance,
QUESTION 18 hindi inhibition
1. Carbapenem with the longest half-life:
Doripenem
1 points
QUESTION 24 both
1. Aztreonam has activity against: neither
aerobic gram-negative bacteria
P. aeruginosa
both
Neither
*monobactams coverage: aerobic Gr(-)
organisms, P. aeruginosa is also aerobic
gr(-)
1 points
QUESTION 7
QUESTION 25
Which can be used to treat MRSA infection
1. Penicillins have little activity against Gram-
Ceftriaxone
negative rods.
Cefotaxime
True Cefepime
Ceftaroline
False
QUESTION 8
QUESTION 1 Which can be used to treat Enterobacter infection
Oxacillin is active against Ceftriaxone
staphylococci Cefotaxime
enterococci both
both neither
neither *Cefepime dapat?
*little to no activity against Gr(-), Enterococci and
anaerobic QUESTION 9
Which has activity against anaerobes
QUESTION 2 Cefoxitin
Which cephalosporin is excreted thru the bile? Cefofetan
Cefoperazone both
Ceftriaxone neither
both *Cefoxitin & Cefotetan - have activity against anaerobes
neither
QUESTION 10
QUESTION 3 Penicillin can be used to treat pneumococcal menigitis.
Dicloxacillin is active against True
Gram negatives False
anaerobes
both
neither
*little to no activity against Gr(-), Enterococci and
anaerobic
QUESTION 4
Component of peptidoglycan bacterial cell wall
N-acetylglucosamine
Beta-lactam *dapat penicillin-
both susceptible pneumococci?
neither
QUESTION 11
QUESTION 5 Excretion of Nafcillin is primarily thru:
Acid stable penicillin: Renal
Penicillin V Biliary
Benzathine penicillin both
both neither
neither
QUESTION 12
QUESTION 6 Drug of choice for surgical prophylaxis
Which can be used to treat meningicoccal meningitis Cefazolin
Ceftriaxone Cefoxitin
Cefotaxime Cefofetan
Ceftriaxone
QUESTION 13 Cefixime
Adverse effect of seizure if given at high doses is Ceftazidime
associated with: both
Penicillin G neither
Oxacillin
Ampicillin
Piperacillin
QUESTION 14
Adverse effect of bleeding disorder is associated with:
QUESTION 21
Cefotetan This may cause psychosis and convulsion at high doses:
Cefepime Cycloserine
Cefuroxime
Bacitracin
Ceftriaxone Daptomycin
Fosfomycin
QUESTION 22
Drug of choice against Beta hemolytic streptococcal
pharyngitis
Penicillin G
Penicillin V
Oxacillin
Ampicillin
*benzathine penicillin = formulated with penicillin G?
QUESTION 23
This is cell wall synthesis inhibitor is produced by
Bacillus subtilis
QUESTION 15 Cycloserine
Resistance mechanism to penicillin: Bacitracin
Production of efflux pump Daptomycin
Beta-lactamase production Vancomycin
both Fosfomycin
neither
QUESTION 24
QUESTION 16 Nafcillin is active against
Cephalosporins has activity against: Gram negatives
Streptococci anaerobes
Staphylococci both
both neither
neither *little to no activity against Gr(-), Enterococci and
anaerobic
QUESTION 17
Carbapenem not active against P. aeruginosa: QUESTION 25
Doripenem Drug active against Pseudomonas
Ertapenem Ticarcillin
Imipenem Carbenicillin
Meropenem both
neither
QUESTION 19
Glycopeptide which can be administered intramuscular:
Vancomycin
Teicoplanin
Telavancin
Dalbavancin
Oritavancin
QUESTION 1
QUESTION 20 Drug active against Pseudomonas
Anti-pseudomonal activity is seen with this Ampicillin
cephalosporin: Oxacillin
both
neither
QUESTION 3 QUESTION 16
Adverse effect of acute kidney injury when coimbined Oxacillin is active against
with Vancomycin is associated with: staphylococci
Piperacillin anaerobes
Oxacillin both
Ampicillin neither
Penicillin G
QUESTION 4
Dicloxacillin is active against
staphylococci
streptococci
both
neither
QUESTION 17
Acid stable penicillin:
QUESTION 7
Dicloxacillin
Component of peptidoglycan bacterial cell wall
Ampicillin
Beta-lactam
both
N-acetylmuramic acid
neither
both
*Penicillin V, Amoxicillin, Dicloxacillin acid-stable
neither
QUESTION 18
QUESTION 10
Lipoglycopeptide which can disrupt cell membrane
Which can be used to treat pneumococcal meningitis
potential and inhibit RNA synthesis:
Ceftriaxone
Vancomycin
Cefotaxime
Teicoplanin
both
Telavancin
neither
Dalbavancin
Oritavancin
QUESTION 11
Which can be used to treat pneumococcal meningitis
QUESTION 19
Ceftriaxone
Which cephalosporin is excreted thru the bile?
Cefoxitin
Cefotaxime
both
Cefixime
neither
both
neither
QUESTION 12
Which can be used to treat Listeria monocytogenes
QUESTION 21
infection
Nafcillin is active against
Ceftriaxone
streptococci
Cefotaxime
anaerobes
both
both
neither
neither
QUESTION 13
QUESTION 23
This is cell wall synthesis inhibitor is produced by
Adverse effect of hypoprothrombinemia is associated
Amycolatosis orientalis
with:
Cycloserine
Cefotetan
Bacitracin
Cefepime
Daptomycin
Cefuroxime
Vancomycin
Ceftriaxone
Fosfomycin
QUESTION 24
QUESTION 14
Which has activity against anaerobes
Antistaphylococcal penicillins are resistant to Beta-
Cefoxitin
lactamases.
Cefaclor
True
Cefuroxime
False
Cefprozil
*Cefoxitin & Cefotetan - have activity against anaerobes
QUESTION 25
Resistance mechanism to penicillin:
Inhibition of Beta-lactamase
Alteration of the PBP's
both
neither
1. Which can cross the Blood Brain Barrier 1. This/These aminoglycosides is/are most likely to
Clindamycin cause auditory damage
Amikacin
Erythromycin
Neomycin
Both
Both
Neither
*chlorampheni Neither
col & linezolid *Neomycin, Kanamycin, Amikacin
to methinks 1 points
QUESTION 7
1 points 1. This inhibits bacterial protein synthesis by binding to
QUESTION 2 50S ribosome preventing peptide chain elongation
1. This/These aminoglycosides is/are most nephrotoxic thru blocking the exit tunnel
Neomycin Tetracyclines
Tobramycin Macrolides
Both Lincosamide
Neither Chloramphenicol
*Gentamycin & Tobramycin to Oxalidinones
1 points
1 points
QUESTION 3
1. Adverse reaction of gray baby syndrome is QUESTION 8
associated with 1. This inhibits bacterial protein synthesis by revesibly
Tetracyclines binding to 30S ribosome blocking the incoming
charged tRNA binding to the acceptor site
Erythromycin Tetracyclines
Clindamycin Macrolides
Chloramphenicol Lincosamide
Streptogramin Chloramphenicol
1 points Oxalidinones
QUESTION 4
1 points
1. Adverse reaction of enamel dysplasia is associated
with QUESTION 9
Tetracyclines 1. Clinically used against Methicillin-resistant
Staphylococci
Macrolides Streptogramin
Clindamycin Linezolid
Chloramphenicol Both
Linezolid Neither
1 points 1 points
QUESTION 5 QUESTION 10
1. Adverse reaction of Aplastic Anemia is associated 1. Protein Synthesis inhibitor which is broad spectrum
with and bactericidal
Tetracyclines Tetracyclines
Erythromycin Chloramphenicol
Clindamycin Both
Chloramphenicol Neither
Streptogramin *Chloramphenicol: Bacteriostatic: most
susceptible organisms; Bactericidal: strains of H
1 points influenzae and N meningitidis (most common
QUESTION 6 causes of meningitis in children)
1 points *Streptomycin and Gentamicin
QUESTION 11 1 points
1. Protein Synthesis inhibitor which is broad spectrum QUESTION 16
and bacteriostatic 1. Adverse effects of aminoglycosides include/s:
Tetracyclines nephrotoxicity
Chloramphenicol respiratory paralysis
Both Both
Neither Neither
*Adverse effects: ototoxicity, nephrotoxicity,
1 points
neuromuscular blockade (respiratory
QUESTION 12 paralysis), infrequent hypersensitivity
1. Fungal origin of Gentamicin:
1 points
Streptomyces erythreus
QUESTION 17
Streptomyces lincolnensis 1. Mechanism/s of resistance against tetracyclines:
Streptomyces griseus ribosome protection
Micromonospora purpurea altered or deleted receptor protein on 30S
Streptomyces mediterranei Both
1 points Neither
*Impaired influx or increased efflux, ribosome
QUESTION 13
protection, enzymatic inactivation
1. Drug of choice against Diptheria
Tetracyclines 1 points
QUESTION 18
Erythromycin
1. Quantitative Comparison: Half-Life
Clindamycin Clarythromycin > Azithromycin
Chloramphenicol Clarythromycin < Azithromycin
Linezolid Clarythromycin = Azithromycin
1 points 1 points
QUESTION 14 QUESTION 19
1. Aminoglycoside inhibit protein synhesis by this/these 1. Quantitative Comparison: Half-Life
mechanism: Doxycycline > Minocycline
breaking of polysomes
Doxycycline < Minocycline
inhibiting translocation from acceptor to donor
Doxycycline = Minocycline
site
Doxy = 18h, Mino = 16h
Both
1 points
Neither
QUESTION 20
*Breaking up polysomes into 1. Which is/are an enzyme inhibitor:
nonfunctional monosomes, Interfering the Clarythromycin
initiation complex of peptide formation,
Telithromycin
Misreading mRNA by incorporating
incorrect amino acids resulting to a Both
nonfunctional protein Neither
1 points *Clarithromycin, Erythromycin, Telithromycin
QUESTION 15 1 points
1. This/These aminoglycosides is/are most QUESTION 21
vestibulotoxic 1. Which is a ketolide?
Amikacin Spectinomycin
Kanamycin Fidaxomicin
Both Telithromycin
Neither Streptomycin
Clarithromycin 1. Adverse reaction of Fanconi Syndrome is associated
with:
1 points a. Tetracyclines
QUESTION 22 b. Macrolides
1. Which is a glycylglycine? c. Clindamycin
Tigecycline d. Chloramphenicol
Fidaxomicin e. Streptogramin
2. Adverse reaction of Acute Cholestatis Hepatitis is
Solithromycin associated with:
Dalfopristin a. Tetracyclines
b. Erythromycin
Tedizolid c. Clindamycin
1 points d. Chloramphenicol
3. Drug of choice against Anaerobes
QUESTION 23
a. Tetracyclines
1. Aminoglycosides exhbitics synergistic killing with:
b. Erythromycin
penicillins
c. Clindamycin
vancomycin d. Chloramphenicol
Both *not sure if both tetracyclines and
clindamycin or clindamycin lang
Neither 4. Which is a Fluroketolide?
a. Tigecycline
1 points
b. Fidaxomicin
QUESTION 24 c. Solithromycin
1. Mechanism of resistance against aminoglycosides: d. Dalfopristine
altered or deleted receptor protein on 50S e. Tedizolid
increased efflux by an active transport protein 5. Clinically used against Methicillin-resistant
Staphylococci
Both
a. Tigecycline
Neither b. Linezoid
*Primary mech: Plasmid-mediated c. Both
formation of inactivating enzymes d. Neither
(Production of a transferase enzyme that 6. This inhibits bacterial protein synthesis by binding to
inactivates the aminoglycoside by 23S ribosome preventing formation of ribosome
complex
adenylylation, acetylation, &
a. Tetracyclines
phosphorylation) b. Macrolides
*Other mech: Resistant due to failure to c. Lincosamide
penetrate into the cell (Impaired entry of d. Chloramphenicol
aminoglycoside Due to mutation or e. Oxalidinones
deletion of a porin protein); Receptor on 7. Aminoglycoside inhibit protein synhesis by this/these
the 30S ribosomal subunit may be deleted mechanism:
or altered due to mutation 8. Interfering with formation of initiation
1 points complex of peptide
9. inhibiting translocation from acceptor
QUESTION 25
to donor site
1. Absorption is impaired by food intake
Tetracycline 10. Both
11. Neither
Doxycycline
12. Which can cross the blood brain barrier
Both
a. Chloramphenicol
Neither b. Erythromycin
*Tetracycline, Demeclocycline, Omadacycline c. Both
(almost all tetracyclines EXCEPT Doxycycline d. Neither
and Minocycline) *Chloramphenicol, Linezolid methinks
13. Excretion of Tetracyclines
SET 2 a. Renal
b. Biliary
c. Both c. Both
d. Neither d. Neither
14. Tetracyclines enter the bacterial cell by: 4. Mechanism of resistance against tetracyclines:
a. Passive diffusion a. Production of transferase enzyme
b. Active transport b. Altered or deleted receptor proteinn on 30S
c. Both c. Both
d. Neither d. Neither
15. This/These aminoglycosides is/are most nephrotoxic 5. Which is/are an enzyme inhibitor:
a. Kanamycin a. Erythromycin
b. Streptomycin b. Clarythromycin
c. Both c. Both
d. Neither d. Neither
*Neomycin, kanamycin, and amikacin: most 6. Which can cross the placenta
likely to cause auditory damage a. Tetracycline
*Streptomycin and gentamicin: most b. Chloramphenicol
vestibulotoxic c. Both
*Neomycin, tobramycin, and gentamicin: d. Neither
most nephrotoxic *Chloramphenicol, tetracyclines,
16. Mechanism of resistance against aminoglycosides: erythromycin
a. Impaired entry into the cell 7. This/These aminoglycosides is/are most nephrotoxic
b. Production of transferase enzyme a. Gentamicin
c. Both b. Neomycin
d. Neither c. Both
17. Absorption is impaired by food intake d. Neither
a. Erythromycin 8. This/These aminoglycosides is/are most
b. Tetracycline vestibulotoxic
c. Both a. Gentamycin
d. Neither b. Neomycin
18. Quantitative comparison: Half-life c. Both
a. Demeclocyline > Tetracycline d. Neither
b. Demeclocyline < Tetracycline 9. Mechanism of resistance against tetracyclines:
c. Demeclocyline = Tetracycline a. Enzymatic inactivation
19. Quantitative comparison: Half-life b. Altered or deleted receptor proteinn on 30S
a. Tetracycline > Tigecycline c. Both
b. Tetracycline < Tigecycline d. Neither
c. Tetracycline = Tigecycline 10. Adverse reaction of arthralgia-myalgia syndrome is
20. Mechanism of resistance against tetracyclines: associated with
a. Increased efflux by active transport a. Tetracyclines
b. Altered or deleted receptor protein on 30S b. Macrolides
c. Both c. Clindmaycin
d. Neither d. Chloramphenicol
SET 3 e. Streptogramin
1. This/These minoglycosides is/are most likely to 11. Absorption is impaired by food intake
cause auditory damage a. Tetracycline
a. Tobramycin b. Minocycline
b. Gentamycin c. Both
c. Both d. Neither
d. Neither 12. Aminoglycosides exhibits:
2. Undergoes enterohepatic circulation a. Time dependent bacterial killing
a. Tetracycline b. Concentration dependent bacterial killing
b. Chloramphenicol c. Both
c. Both d. Neither
d. Neither 13. Administration of aminoglycosides maybe:
3. Aminoglycoside inhibit protein synhesis by this/these a. IV
mechanism: b. IM
a. Misreading of mRNA c. Both
b. Inhibiting release of uncharged tRNA from d. Neither
the donor site
14. Clinically used against Vancomycin-resistant E.
Faecium
a. Streptogramin
b. Linezolid
c. Both
d. Neither
SET 3
1. Fungal origin of Clindamycin:
Streptomyces erythreus
Streptomyces lincolnensis
Streptomyces griseus
Micromonospora purpurea
Streptomyces mediterranei
2. Mechanism of resistance against aminoglycosides:
a. Production of transferase enzyme
b. Altered or deleted receptor protein on 30s
c. Both
d. Neither
3. This inhibits bacterial protein synthesis by binding to
50s ribosome interfering with initiation complex
formation and translocation
a. Tetracyclines
b. Macrolides
c. Lincosamide
d. Chloramphenicol
e. Oxalidinones
*Parehas sila MOA :<
1. Clinically used for treatment of gonococcal infection:
SET 1 Ciprofloxacin
1. Classify: Sulfacetamide
Levofloxacin
Oral Absorbable Sulfonamide
Both
Oral Nonabsorbable Sulfonamide
Neither
Topical Sulfonamide
*Ciprofloxacin and levofloxacin: are no longer
1 points recommended for the treatment of gonococcal
QUESTION 2 infection in the USA, as resistance is now
1. Adverse reaction of Steven-Johnson syndrome is common
associated with *Gemifloxacin: recommended in combination
Sulfonamide with azithromycin as an alternate to ceftriaxone
1 points
Trimethoprim
QUESTION 8
Ciprofloxacin 1. Trimethoprim-sulfamethoxazole is the drug of choice
1 points for toxoplasmosis.
QUESTION 3 True
1. Clinically used for menigococcal carrier :
False
Ciprofloxacin
*TMP-SMX: DOC for P jiroveci pneumonia,
Levofloxacin toxoplasmosis, nocardiosis
Both 1 points
QUESTION 9
Neither
1. Mechanism of action of Quinolones
*Ciprofloxacin, Levofloxacin, Moxifloxacin =
suitable for eradication of meningococci from inhibits DNA gyrase
carriers inhibits dihydrofolate reductase
1 points Both
QUESTION 4
Neither
1. Absorbed Sulfonamides are removed from the body
*Quinolones inhibit bacterial topoisomerase II
by:
(DNA gyrase) and topoisomerase IV
urinary glomerular filtration
1 points
biliary excretion QUESTION 10
both 1. Adverse effect of QTc interval prolongation is
associated with
neither
Moxifloxacin
1 points
Levofloxacin
QUESTION 5
1. Mechanism of action of Sulfonamides Both
inhibits DNA gyrase Neither
inhibits dihydropteroate synthase *Gatifloxacin, Levofloxacin, Gemifloxacin,
Moxifloxacin: Prolongation of the QTc interval
Both
1 points
Neither QUESTION 11
1 points 1. Which is/are respiratory quinolones:
Moxifloxacin
QUESTION 6
1. Mechanism of action of Trimethoprim Ciprofloxacin
inhibits DNA gyrase Both
inhibits dihydrofolate reductase Neither
Both *Levofloxacin, gemifloxacin, and moxifloxacin:
so-called respiratory fluoroquinolones—are
Neither
effective for treatment of lower respiratory
1 points tract infections
QUESTION 7 1 points
QUESTION 12 inhibits dihydrofolate reductase
1. Hepatic biotransformation of absorbed sulfonamide Both
includes: neither
neither *Quinolones inhibit bacterial topoisomerase II (DNA gyrase)
and topoisomerase IV
acetylation
both 5. Classify: Sulfasalazine
Glucoronidation Oral Absorbable Sulfonamide
*Metabolized in the Liver: Acetylated or Oral Nonabsorbable Sulfonamide
Glucuronidated Topical Sulfonamide
1 points 6. Trimethorpim-sulfamethoxazole is the drug of choice for
QUESTION 13 nocardiosis.
1. Which drug combination is used to treat falciparum True
malaria: False
sulfamethoxazole + trimethoprim *TMP-SMX: DOC for P jiroveci pneumonia, toxoplasmosis,
sulfadiazine + pyrimethamine nocardiosis
SET 3
2. Classify: Sulfamethoxazole
Oral Absorbable Sulfonamide
Oral Nonabsorbable Sulfonamide
Topical Sulfonamide
QUESTION 6
Drug of choice for prophylaxis against disseminated M. avium
complex (MAC)
Azithromycin
Clarithromycin
Both
Neither