cardiovascular

The least likely to cause postural hypotension? B blocker

2- used in emergency and cause prompt hypotensive effect Sod Nitroprusside

3-drug contains Iron and CN in its structure and decreases emergency blood
pressure Na nitroprusside

4-The " first dose" effect is characterized by marked hypotension and syncope ,
caused by :doxazosin , prazosin,terazosin

5- Pt with hypertension and gout ,the antihypertensive drug is : Atenolol (Tenormin)

6-Thiazide diuretics should Not used(CI) as first line ttt for HTN in patient has ?Gout

7-Patient with hypertension and congestive heart failure with ejection fraction 28% which
antihypertensive for him: Nisoldipine

8-70 yr old diabetic pt on oral hypoglycemica and has hypertension,which

antihypertensive drugs is Not recommended Atenolol( BB)
N.BLosartan & enalapril are (ARBs/ACE) which are the first line since they provide
nephroprotection , Beta blockers are indicated and are as effectively as ACE .. But used
with caution as they cause masking for hypoglycemia and prolong hypoglycemic
recovery phase.
9- Pt with HTN and DM having Arrhythmia what is the best choice for him? Verapamil

10- Patient suffered from emergency Hypertension with Angina he undergo surgery,
he is taking hydrochlorothiazide and after surgery he was under some ventilation; What
is best antihypertensive drug to give him; Metoprolol
11-After treating with hydralazine what is the drug to treat Angina; Nitroglycerin

12-Drug associated with life-threating hyperkalemia; Spironolactone(k+sparing

diuretic)
** drug cause high elevation in potassium( k+sparing diuretic): spironolactone
** Triamterene and Spironolactone are: k+sparing diuretic

13-Minoxidil M.O.A decreased arterial pressure &increase contractility(increase

heart rate).
14- Timolol is contraindicated(CI) in all the following Except: HTN
15- Beta blocker use in all Except: Bronchial asthma
16-Hosptalized patient with Angina which Antihypertensive is best for him Metoprolol

17-Pregnant woman having HTN which can be used : 1st methyldopa,

2nd NIFEdipine , 3rd labetalol

18. NIFEdipine NOt used in 1- early abortion

2- angina pectoris  ( but used in prinzmetal angina=Rest angina)
3-preclampsia for (the answering you will choose by this order )
 cardiovascular
19-A stomach upset radiating to be chest pain is: Angina
20-Gastric pain after heavy meal radiating to the neck and lower jaw: Atypical angina
21-prinzmetal angina: Rest angina& sudden spasm ,with atherosclerosis, and
respond to Calcium channel blocker (CBs NIFEdipine) and nitroglycerin

22-patient admitted to ER with chest pain, diagnosed as prinzmetal angina ,regarding

this which is true : All are true except D (Not responsive to CCB and nitroglycerin)

23-which is CI( not used )in prinzmetal angina? Atenolol

24- Which is contraindicated in prinzmetal angina : B-Blocker(Atenolol)

25- Not use in angina : Losartan

( Angina treatment 1st line Nitrates then CCBs or BBs, avoid ARBs & ACIs)
26-ICU patient with cardiovascular disease & Angina ,he was given Hydralazine.
Drug that decrease his Blood pressure in 2 hours can be  B-blockers
(metoprolol) (Atenolol)

27-Which drug can counteract the increased risk of angina caused by the use of
hydralazine for this patient Nitroglycerin

28- AD is a 58 year old male with diabetes, angina and erectile dysfunction. His
physician consults the pharmacist in order to decide if AD would be a good candidate
for Sildenafil. Sildenafil is CONTRAINDICATED, if he takes: isosorbide 5-mononitrate.
**isosorbide 5-mononitrate cause Tachycardia
29- a patient attended to ICU with high blood pressure and previous angina, then had a
cardiac surgery and put on a mechanical ventilator :used in mechanical ventilation to
reduce unwanted respiratory movement vecuronium & pancuronium

30- Drug aggravates angina and causes ischemic tachycardia : Hydralazine

31-In the treatment of cardiac arrhythmias, amiodarone (cordarone) is most similar in

action to : sotalol As amiodarone is (K+channel blocker Class 3) & Sotalol class 2&3

32- Male patient , he is a smoker and he is taking an antiarrhythmic medications ,

which of the following drugs should be avoided : Verapamil
**78years old male patient has COPD and is a smoker, he is taking an antiarrhythmic
medications, which of the following drugs should be avoided:Amiodrone (if can
choose more than one , so also choose verapamil as it's CI with smoking)

33-patient with hypertension put on antihypertensive drug, after few months developed
heart failure manifested as reduction in heart rate and contraction, which
antihypertensive drug patient put on: Verapamil
34-pt with Myocardial infarction,Drug as prophylacsis to avoid arrhythmia? Metoprolol
35- Antiarrythmic used for patient with atrial fibrillation:- propafenon(1st) - sotalol(2nd)
 cardiovascular
36-Not used for atrial fibrillation, lidocaine
NB. used in AF: Propafenone, sotalol, flecanide, amidarone & Labetolol
except lidocaine (used for ventricular arrhythmias)
37- Patient with arrhythmia discharged from the hospital which medication used to
control his condition :- verapamil
38-Common side effects of anti-arrhythmic drug: Torsade de pointe
39- pt. has arrhythmia come to ICU ALL true Except: Antiarrhythmic safer than
surgery
CASE About Arrhythmia :a-most cause of recurrent arrhythmia due to reentry
b-Most Of them is Calcium and sodium blocker c-SA node is the pace maker
d.anti-arrythmic safer than surgery ans a&b&c if except you will choice d
40- Patient with Arrhythmia given medication that decrease the velocity and force of
contractility which one of this drugs :Verapamil

41-Digoxin M.O.A a- Suppression of AVnode conduction (cause some atrioventricular

block). b- enhance vagal tone and decrease ventricular rate to fast atrial arrhythmias
c- Inhibit Na+ / K+ATPase Pump(increase contractility) D-All
42-M.O.A of Digitalis(DIGOXIN) all true Except:  Decrease vascular resistance
43-Digoxin act on Na+ / K+ATPase Pump
44- Digoxin is CI in? Complete heart block
45-Digoxin can be given in all except: -Complete cardiac block

46-Increase renal clearance of digoxin phenytoin

NB.Verapamil,Quindine and amiodarone …etc decrease the renal clearance of digoxin

47-Which drug induces bradycardia?  verapamil digoxin atenolol/betablocker All

NB. Digoxin: Positive inotropic, Negative chronotropic so decrease heart rate
36-all of the following are side effects of digoxin toxicity except: acute renal failure
48-Secondary prevention for reinfarction: Aspirin
49- Patient with glaucoma and blood pressure 220/110 and hypertensive crisis and
ask which to avoid :- fenoldopam ( Fenoldopam increase IOP so CI in glaucoma)
50- Niacin: Has the Highest effect on: HDL
case about patient have lowered HDL :Niacin (Nicotinic acid )
-patient diagnosed with Hyperlipidemia and decreased HDL , what to give?Niacin 

51-Lipitor is used for which type of hyperlipidemia markers : IIA & IIB
52- patient took lovastatin(statins) all are side effect except: renal dysfunction

53-Atorvastatin 10mg =20 mg simvastatin

54-Simvastatin causes serious interaction with: amiodarone

55- loop diuretic CI in ALL except:- renal impairment
 cardiovascular
56- Pt with hypertension and renal failure, the diuretic for him:Furosemide(loop)
57-Thiazide diuretic doesn’t cause hyperkalemia  & hypocalcemia
N.B(It causes K depletion, hypercalcemia & hyperurecemia so can cause gout)

58- Which is used in patient with pulmonary edema and heart failure:  furosemide

59-Which not caused by furosemide Metabolic acidosis

60- bumetanide( loop diuretic)true about it : Cause Ototoxicity, Need potassium

treatment with it ,Contraindicated with sulphonamide sensitivity All of the above

61-All are route of administration of nitroglycerin except :-oral

62-When a patient take Glyceryl trinitrate (nitroglycerin) tablets they must:
store them in a tightly closed glass bottle(as is highly sensitive to light and moisture)
63-The role of B-blocker in Myocardial Infarction is all except: Increase O2 demand
64- The cough in ACE inhibitors: EXCEPT: Dose related
65-patient on Thiazide and was given additional antihypertensive which have resulted
in decrease in blood pressure in first 2 hours atenolol

66-drug should be monitored with elderly pt : propranolol

NB.it lipophylic so increase accumulation
67-drugs acts as enzyme inhibitor on the first dose enalapril
68-which one is a pro drug: enalapril
69-Patient undergo cardiac surgery they gave him dobutamine infusion, the rule of
infusion is; None of the above
NB. Dobutamine act as beta 1 receptor agonist which have sympathomimetic
effect used for heart failure

70-dobutamine act by -Direct action on beta1 and alpha receptor

71-Propranolol CI (not used) in: Partial AV block.
72-Optimum blood pressure for hypertensive patient, not suffers from any other
problem? >140.. >90 mmHg
73-Which drug is not fully excreted by kidney fosinopril
74-Patient is taking hydrochlorothiazide\ amiloride(K+sparing diuretic)which interact
with them: losartan(ARBs)1st or Enalapril( ACE-I) 2nd
75-Inderal is generic name for: Propranolol(Non-Selective B-blocker)
76-treatment of anemia is : folic a, iron ,vit B12 & erythropoietin * all
77- Case with low no of RBCs & low Hb content,patient on renal dialysis which drug given
with Iron for him Erythropoietin
 cardiovascular
78- vitamin or mineral as iron that increase hemoglobin conc. in blood Hematinic
79- produce blood cell formation(tonsilities,spleen) , it is called : Hematopoietic
80-blood flow and improve blood viscosity :, Hemorheologic
81-medicine that comprises platelet aggregation and fibrinolysis : Hemostatic
82-Megaloblastic anemia(macrocytic =pernicious) :Vit.B12 &Folic acid
83- Patient with sickle cell anemia receive blood transfusion, Signs of liver failure
appear, this is due to overdose of:Iron
84-TTT of sickle cell anemia Hydroxyurea
85-primary mechanism of action of warfarin :Vitamin k reductase inhibitor
86-Erythropiotin : increase HGB, not used in Severe anemia due to acute bleeding
87- which fibrinolytic cause hypersensitivity: Streptokinase
(After administration, antistreptokinase antibodies may remain elevated for up to 1 year)
88- considered fibrin selective(initiates local fibrinolysis ): Alteplase
89- Antiplatelet cause Side Effects of neutropenia, agranulocytosis,& aplastic
anemia: Ticlopidine
90-Outpatient needs anticoagulant :Low molecular weight heparin(LMWH) and
fondaparinux(anti Xa)
91- heparin mechanism of action: inhibit antithrombin 3
92- which Morphine SE patients are having tolerance to: Euphoria Or Analgesia
93-Used as preservatives : Na benzoate & Methyl parabens

94- Sulfasalazine max and daily dose in ulcerative colitis is? Maximum Dose 3-6 g
95-Signs of irritable bowel syndrome(IBS) include:
1-Bloating of stomach. 2- diarrhea and constipation.3-Mucous with stool. d-1,2,3
96- IBS (irritable bowel syndrome)and dr asked the patient to eliminated all dairy
products why?cause. alternatively constipation and diarrhea

97-Which is used in eyes :(dilation of eye) Phenylephrine ✔

98- graph : how much time it will stay in body:24 h
how much conc at time 12 : 5mg/mL how much t max : 3 h
99-Action of insulin except: Decrease liver glucose uptake
100-All cause postural hypotension except: Carvedilol (BB)
101-Pt taking INH,MTX and amiodarone, the side effect : liver
cirrhosis
102-All of these drugs CI with azathioprine except:Propranolol
103-Not use in dry eyes :Chloramphenicol
104- Antiepileptic drug cause acne and hirsutism: Phenytoin
105- receptor/s does Bethanechol act on? Muscarinic
106-Bethanicol used in all except: Urinary Retention due to organ obstruction
107-patient with panic attack what is DOC: benzodiazepines
108- benzodiazepines are all except: -anti pscychotic
109- Patient has a problem in bowel emptying, he develops pain while passing stool.
Which is the least likely condition to cause this problem? Hyperthyroidism
 cardiovascular
110- Pt take DMARDs(Disease Modifying Antirheumatic Drugs),after 2 weeks have eye
problem, Which DMARD related to vision problem: (hydroxyquine)
hydroxychloroquine
111- Which of these drugs contraindicated in Pregnancy: Ganciclovir
112- Patient taking atropine, side effects of atropine like:except
a- decreased intraocular pressure B-constriction of eye pupils c- miosis d- ALL
113-Which treatment is more safely for outpatient with pulmonary embolism:
a- -fondaparinux + low molecular weight heparin
114-Renal monitoring is needed with: Pyrazinamide-PZD Ethambutol
115-- As an antiarythmic drug lidocaine is most similar in action to Phenytoin
116-DOC of hyperlipidemia: statin
117-DOC of hypertriglyceridemia: fenofibrate
118-Study about cell mediated immunity: T Cell
119-Long acting ophthalmic B-blocker: Timolol(non-selective B1&2)
DIAPHRAM 2: t1/2= Co/ 2K
120-All of the following are NOT activated receptors except: Neostigmine
121-A drug that has high risk for thrombosis and MI: celecoxib
122- Which is contraindicated with sulfa sensitivity:Celecoxib
123- Lomotil is a mixture of Atropine and: Diphenoxylate
124- Digoxin cannot be used in which condition: .Left diastolic HF
125- Which is true about Digoxin MOA is:Positive inotropic effect
126- drug given for ductus arteriosus: Indomethacin
127 - Which is S.E of B2 agonist ? Tremor
128- prostaglandin used for glaucoma and eyelash Hypotrichosis:bimatoprost
129- Aortic dissection DOC along with B blocker :Sodium nitroprusside
130- Enalapril Not beneficial effect: Vasodilatation by bradykinnin accumulation
131- heparin mechanism of action. -inhibit antithrombin 3
132- True about SSRI:Safest one to use for long term.
133- Associated with CNS side effects: Mefenamic acid
134- Which of the following causes tachycardia:isosorbide dinitrate
135- patient with erectile dysfunction and take Sildenafil which CI isosorbide dinitrate
136 - Which not used in congestive heart failure: Nefidipine
137 - which of the drugs acts on T-lymphocyte blocking? Abatacept or Alefacept
138 -All are DMARDS except: Prednisolone
139-Pt take DMARDs& after 2 weeks has eye problem! drug cause: hydroxyquine
140-pro-kinetic drug( inc. GIT motility )has anti emetic effect:Domepridone(motilium).
141-which is Not side effect of Salbutamol?-constipation
142-Formula for calculating the dose for a child more than 2 years :
young's rule age/age+12 × ADULTS DOSE✔
 cardiovascular
143- liraglutide is :glucagon like peptide1

144-Controlled drug used for pain during acute MI -morphine

145-T 4 binds to: albumin ,thyroxine binding globulin , all of the above✔ ..
146-What is the medication that’s used in the treatment of glaucoma, medication-
related edema, heart-failure related edema? Acetazolamide
147- Not ACEIs SE: Postural hypotension
148-which if administered with digitalis will not affect its action: Captopril
149-decrease effect of digoxine except : azithromycin(increase digoxin)
150- decrease effect of digoxine except : cycloserine(increase digoxin)
151-Desipramine SE Except: bradycardia(B1agonist)
152- Drug that promote hyperglycaemia in DM except: NSAID
153- Drug that does Not enhance the action of sulfonylurea: Diazoxide(inc.
glucose)
154- which one is Botox side effect: respiratory paralysis
155-histamine autorecepteor:H3
156-Which of the following drugs have single enantiomer ? Escitalopram
157-Cocaine cause all EXCEPT: Peripheral Vasodilation
158-Propanolol & Atenolol S.E cause :fatigue
159-Which of the following is NOT true about Simvastatin?
-Advice to take Simvastatine in the morning.
160-which drug doesn’t cause myopathy ? Cholestyramine

161- Corns are associated with:High pressure from shoes

162-Treatment of Hypoparathyrodism: Dihydrotachysterol
163-Symptoms of Digoxin toxicity : Vomiting
164- The vasopressor effect of epinephrine on the body:Increased blood pressure
Lithium CI with? Ibuprofen
tazobactam>>>> b lactamase inhibitor
57_A long case on a patient on many drugs including furesamide presenting with toxicity
of furesamide (increase respiration ) ,,which of the following is true : respiratory
acidosis✔
90)Ramipril initial daily dose : 10 mg✔
91) drugs excreted in milk should have ? . low protein binding✔
93)Total cholesterol in patient with MI 100✔
94) Drug cause photosensitivity ciprofloxacin [fluoroquinolones]✔
95)Bacteriostatic : doxycyline ✔
96) Vit c and aspirin -vitamin acts as an antioxidant in the stomach to decrease
aspirin-induced stomach damage✔
97)NSAIDs is contraindication with 2. ACEI✔ 3. Diuretics✔
98) Most common cause of frequent urination,low flow rate of urine,and UTI : BPH
✔
 cardiovascular
99)following drug can be given by sublingual route expect : digoxin✔

102)which of the following is NOT associated with hemolytic anemia ? methyl

testosterone✔✔
103)which of the following local anathesia is for topical administration ONLY :
benzocaine✔✔
104)which drug recommended for allergic rhinitis :
a cromoglycolate b nedocromoil c cs d all✔✔
107)immune serum globulin is usually administrated by which type of injection ?
intradermal im iv sc anyone of them✔✔
110)Grape fruit not use with which of the following: Nifedipine
Streptomycin AE is best monitored by 1. Audiometry (mainly)✔✔2. renal
function, ✔✔S.E of streptomycin (nephrotoxicity and ototoxicity)

115)-Which of the following is CI with MAOI

1. Duloxetine, ✔2. fluoxetine, ✔3. Paroxetine ✔
117)-how can you manage the drug interaction between quinolone &
amiodarone : avoid quinolone, ✔
130) Phenothiazine and Prochlorperazine not given with which disease:
Parkinson
131) The group of people which is more susciptable to diseases:-62 years and
above
132)-treatment of Neisseria Meningitis: .ampicillin
133). Diazepam storage condition: 20-25 degree. away from heat , moisture, light.
134). A property of bulk forming laxative:bulk laxatives are gluten free
136) Theophylline doses range between 0.1-0.2 international units ( approx how
much mg)a- 55_110✔
 54- which is weak electrolyte : ephedrine✔
55- Act on disopropyl flurophosphates enzyme: Pralidoxime✔
62- Drug not enter CNS :-ipratropium✔
71-Which of the you CANNOT overcome by making prodrug:Potency✔
92- Which of the following not a risk factor for breast cancer:Early menopause✔
103★patient has closed angle glaucoma which is contraindicated: atropine✔.
107★abscence seizure what is not use:-topiramate
112★treatment of amoeba: -diloxanide ✔ metronodazole✔ emetin✔
-gray baby syndrome >>>chloramphenicol -blue man syndrome>>>>>> amiodarone
122-Digoxin can be given in all except: Cardiac block✔
95- Epinephrine act on which receptor:a) Alpha 1b) Alpha 2 c) Beta 1 d) Beta 2 ALL✔
96-Not used as antifungal: Na picosulfate✔(laxatives)
146-Which of the following ACEI that not to be used for liver problems :-Fosinopril✔
156-Plasma ….. -Glut 1✔ while adipose tissue GLUT4
162- Bethanechol side effects:-cholinergic effect (salivation, sweating, flushing,
decrease BP, bronchospasm)
72) Not used as an antifungal: A-benzoic acid B-sodium picosulfatec- terbinafine d-
tolnaftate 78) Not used in preservatives? sodium picosulfate