10 1 1 634 2036
10 1 1 634 2036
10 1 1 634 2036
A THESIS SUBMITTED TO
THE GRADUATE SCHOOL OF NATURAL AND APPLIED SCIENCES
OF
MIDDLE EAST TECHNICAL UNIVERSITY
BY
HAMİDE FINDIK
FEBRUARY 2009
Approval of the thesis:
Signature :
iii
ABSTRACT
Fındık, Hamide
Ph.D., Department of Chemistry
Supervisor: Prof. Dr. Ayhan S. Demir
The first part of the thesis presents the KMnO4/ carboxylic acid/ organic solvent which
is a powerful reagent for C-C bond formation, aryl coupling reactions and enone
oxidation. The α′-acetoxylation of enones and the α-acetoxylation of aromatic
ketones were carried out with potassium permanganate and acetic acid, in which
acetoxylation products were obtained in 74-96% yields. The same reaction was
carried out with carboxylic acids other than acetic acid, which furnished
corresponding acyloxy ketones with the same regioselectivity. For the first time,
formyloxylation products were synthesized in a 61-85% yield by using formic acid.
The potassium permanganate and acetic acid method was also used for aryl coupling
reactions. The reaction of arylboronic acids and aryl hydrazines in benzene with
potassium permanganate and acetic acid in turn furnished biaryls in a 85-96% yield.
iv
We showed that potassium permanganate/carboxylic acid/organic solvent behaves as
manganese(III) acetate.
In the second part of the thesis, ipso-nitration of arylboronic acids with AgNO2/
TMSCl was performed. Nitration of aromatic compounds is one of the most
extensively studied reactions, and nitroaryl moieties play key roles in the physical
and chemical properties of many target molecules in organic synthesis. For
electrophilic nitration of aromatic compounds, a wide variety of reagents are
available to date. Most of them are very strong nitrating agents and often lead to
further nitration and mixture of isomers. Since most nitrating agents are oxidants,
oxidation of other functional groups can also occur, giving a mixture of products.
Thus, a search for milder and selective nitrating agents is a good research goal. In
this work, we aimed to apply AgNO2/ TMSCl system to ipso nitration of arylboronic
acids.
v
ÖZ
Fındık, Hamide
Doktora, Kimya Bölümü
Tez Yöneticisi: Prof. Dr. Ayhan S. Demir
Bu tezin birinci bölümü C-C bağ oluşumu, aril birleşme reaksiyonları ve enon
oksitlenmelerinde güçlü bir reaktif olan KMnO4/ karboksilik asit/ organik çözücü
sistemiyle yapılan çalışmaları kapsamaktadır. Enonların α'- asetoksillenmeleri ve
aromatik ketonların α-asetoksillenmeleri potasyum permanganat ve asetik asitle
gerçekleştirilmiş ve asetoksilleme ürünleri %74-96 verimle elde edilmişlerdir. Aynı
reaksiyon asetik asit yerine diğer karboksilik asitlerle de denenmiş ve ilgili asiloksi
ketonlar aynı seçicilikle elde edilmişlerdir. Literatürde ilk kez, formik asit
kullanılarak formilasyon ürünleri %61-85 verimlerle sentezlenmişlerdir. Potasyum
permanganat ve asetik asit metodu biaril oluşma reaksiyonlarında da kullanılmıştır.
Aril boronik asitler ve aril hidrazinler benzen içerisinde potasyum permanganat ve
asetik asitle reaksiyona sokulduğunda biariller % 85-96 verimle elde edilmişlerdir.
Çalışmalarımız potasyum permanganat/ karboksilik asit/ organik çözücü sisteminin
Mangan(III) asetat eşdeğeri olarak davrandığını göstermiştir.
vi
Tezin ikinci bölümünde, AgNO2/TMSCl varlığında aril boronik asitlerin ipso
nitrolanması gerçekleştirilmiştir. Aromatik bileşiklerin nitrolanması üzerinde çok
çalışılan bir reaksiyondur ve nitroaril grubu organik sentezdeki birçok hedef
molekülün fiziksel ve kimyasal özelliklerinde büyük rol oynamaktadır. Aromatik
bileşiklerin elektrofilik nitrolanması için çok geniş çeşitlilikte reaktif
bulunabilmektedir. Bunların birçoğu çok güçlü nitrolama ajanlarıdır ve daha ileri
nitrolanmaya ve izomer karışımlarına sebebiyet vermektedirler. Çoğu nitrolama
ajanları yükseltgeyici olduklarından, diğer fonksiyonel grupların oksidasyonları da
gerçekleşebilmekte ve birden çok ürün oluşumuna sebep olmaktadır. Bu nedenle,
daha ılımlı ve seçici nitrolama ajanlarının bulunması iyi bir araştırma konusudur. Bu
çalışmada, AgNO2/ TMSCl sistemi arilboronik asitlerin ipso-nitrolanmasında
uygulanmış ve nitro bileşikleri yüksek verimlerle elde edilmişler. Böylece yeni
alternatif bir nitrolama yöntemi geliştirilmiştir.
vii
To My Family,
viii
ACKNOWLEDGEMENTS
I wish to thank to Fatos Doganel Polat, Seda Karayılan and Zehra Uzunoğlu for their
and kind help for my routine in NMR analysis.
ix
TABLE OF CONTENTS
ABSTRACT................................................................................................................iv
ÖZ................................................................................................................................vi
DEDICATION...........................................................................................................viii
ACKNOWLEDGEMENTS.........................................................................................ix
TABLE OF CONTENTS.............................................................................................x
LIST OF TABLES....................................................................................................xiii
LIST OF FIGURES...................................................................................................xiv
CHAPTERS
1.INTRODUCTION………………………………………………...………………..1
x
1.2.7.1. Formation of Higher Saturated, Unsaturated and
Acetoxyketones…………………………………………..……….....14
1.2.7.2. Formation of Dihydrofurans…………………..…...……......15
1.2.7.3. Formation of Tetralones……………………..…..………….17
1.2.7.4. Formation of 1,4-Diketones……………………....……..….18
1.2.8. Aromatic Substitution Reactions………………………....…….…….20
1.2.9. Mn(OAc)3 Mediated Biaryl Coupling Reactions………….…...……..21
1.2.10. Tandem Oxidative Cyclizations with Various Mn(III) Reagents and
Cu(OAc)2………...…………………………………………….…………....25
1.2.11. Mn(III) Acetate Mediated Oxidation of α,β-Unsaturated Ketones….28
1.2.12. Mechanistic Considerations………..…………………….……….…31
1.3 Reinvestigation of the synthetic and mechanistic aspects of Mn(OAc)3….....….38
1.4. Ipso nitration with arylboronic acids………………………..…………....….…39
1.4.1. Nitration methods of arylboronic acids…………….…..…….…….…40
1.4.2. AgNO2/TMSCl: General application………………...………..….….42
1.5. Aim of the work……………..………………………………………….........…44
xi
3. EXPERIMENTAL……………………………………………......………………72
4.CONCLUSION…………..….…………………………..………………………...86
REFERENCES……………………...………………….…………………….……..88
APPENDIX A- NMR DATA…………………………...……………………..……99
CURRICULUM VITAE…………………………………………………………...122
xii
LIST OF TABLES
TABLES
Table1. Routes to Manganese (III) Acetate………...……..........................................4
Table 2. Solubility of Manganese (III) Acetate in Acetic Acid-Water Mixtures.........5
Table 3. Examples to application of in situ generation of Mn(OAc)3 to the α'-
acetoxylation of enones...............................................................................................48
Table 4. Oxidation of aromatic ketones and enones with KMnO4/AcOH.................51
Table 5. Oxidation of aromatic ketones and enones with KMnO4/RCOOH.............53
Table 6. Synthesis of biaryls from arylhydrazines via KMnO4/CH3COOH
system………………………………………...………………………………….….56
Table 7. Synthesis of biaryls from arylboronic acids via KMnO4/CH3COOH
system………………………………...…………………………………….……….57
Table 8. Synthesis of dihydrofuran derivatives via KMnO4/acetic acid/benzene
system…………………………………...………………………………….……….61
Table 9. Enone oxidation reactions with Mn(OAc)3 and KMnO4/AcOH/benzene
system under MW radiation…………………..……………………………..…..…..65
Table 10. Aryl coupling reactions with Mn(OAc)3 and KMnO4/AcOH/benzene
system under MW radiation……………..……………………………………..……67
Table 11. Ipso-nitration products and yields………………………..…………...….70
xiii
LIST OF FIGURES
FIGURES
Figure 1.1. Addition reaction to olefinic systems in the presence of manganese (III)
acetate…………………………..……………………….……………………………3
Figure 1.2. General reaction pattern for indirect oxidation mechanism of manganese
(III) acetate………………………………………………………………………....…3
Figure 1.3. Formation of γ-lactones via Mn(OAc)3 oxidation………..…….……….7
Figure 1.4. Mn(III) acetate initiated addition of acetic anhydride to
olefines……………………………………………………………………..…………8
Figure 1.5. Mn(III) acetate initiated addition of acetic acid to an α-olefin in acetic
anhydride-acetic acid mixtures……………………………………………...……..…9
Figure 1.6. Carbenium ion …………………………………………..…………..…10
Figure 1.7 Oxidative addition of acetic acid to simple olefins
.....................................................................................................................................11
Figure 1.8. Oxidative addition of carboxylic acids to simple
olefins..........................................................................................................................11
Figure 1.9. Formyloxy radical ...................................................................................12
Figure 1.10. Reactions of acyl and formylalkyl radicals………..………..….….….13
Figure 1.11. Addition of simple ketones to olefins in the presence of manganese (III)
acetate …………………………………………………..……………………….….14
Figure 1.12. Primary, secondary and tertiary radicals…………………..…….....…15
Figure 1.13. Formation of dihydrofurans from readily enolizable ketone 18 and
olefin 19 in the presence of manganese (III) acetate ……………………..…..…….16
Figure 1.14. Oxidation of ethyl acetoacetate 24 in the presence of styrene
25…………………………………………………………………………….….…...17
xiv
Figure 1.15. Synthesis of α-tetralones from acetophenone 27 and olefin 10 in the
presence of manganese (III) acetate ………………………..…….………..……..…18
Figure 1.16. Formation of 1,4- diketone 31 via reaction of ketone 29 with
isopropenyl acetate 30…………………………………………………..….…..……19
Figure 1.17. Addition of cyclohexanone to isopropenyl acetate……...……..…...…19
Figure 1.18. Aromatic substitution reactions by radicals generated by manganese
(III) acetate.……………………………………….……………………….…..….…20
Figure 1.19. Reaction of arylhydrazine derivarives with benzene via
manganese(III)acetate……………………………………………………….....……21
Figure 1.20. Azobenzene, phenyl acetate, pyrazole derivative………………..……22
Figure 1.21. oxidation of monoarylhydrazines with Mn(III)…...……………..……23
Figure 1.22. Synthesis of heterobiaryls from arylhydrazines with
Mn(OAc)3...................................................................................................................23
Figure 1.23. Synthesis of biaryls from arylboronic acids with Mn(OAc)3……..…..24
Figure 1.24. Synthesis of heterobiaryls from arylboronic acids with
Mn(OAc)3……………………………………………………………………….…..25
Figure 1.25. Tandem oxidative cyclizations with various Mn(III) reagents and
Cu(OAc)2………………………………………………………………………..…..26
Figure 1.26. Tandem oxidative cyclization of 50 with various Mn(III) reagents and
Cu(OAc)2....................................................................................................................27
Figure 1.27. Mn(OAc)3 mediated oxidation of α,β-unsaturated ketones...................28
Figure 1.28. Synthesis, reduction and hydrolysis of α-acyloxy- β-alkoxy- α,β-
unsaturated ketones……………………………………………..………….……..…29
Figure 1.29. Acyloxilation of enones with manganese (III) acetate in combination
with manganese (II) carboxylate....……………………………………………....….30
Figure 1.30. Acyloxilation of enones with manganese (III) acetate in combination
with carboxylic acids………………………………………………………...…..….31
Figure 1.31. Mechanism of oxidation of monocarbonyl substrates with
Mn(OAc)3.2H2O…………………………………………………...…………..……32
Figure 1.32. Mechanism of oxidation of α-alkyl β-keto esters………………..…....33
Figure 1.33. Rate-determining step in oxidation of α-alkyl β-keto esters…….……33
Figure 1.34. Oxidation of γ-carboxy radicals to γ-lactones…………………..…….35
xv
Figure 1.35. Suggested enolate mechanism for oxidation of enones to the α'-
acetoxyenones with Mn(OAc)3……………………………………………..……….37
Figure 1.36. Suggested radicalic mechanism for oxidation of enones to the α'-
acetoxyenones with Mn(OAc)3………………………………………………..…….38
Figure 1.37. Improved procedure based on the use of acetic acid as a co-
solvent……………………………………………………………………………..…39
Figure 1.38. Nitration of arylboronic acids with Crivello’s reagent……………......40
Figure 1.39. Ipso-nitration of arylboronic acids using inorganic nitrate salt and
chlorotrimethylsilane……………………………………………………..………....41
Figure 1.40. Suggested mechanism for the regioselective nitration of arylboronic
acid……………………………………………………………………….………....42
Figure 1.41. Synthesis of furoxanes via reaction of alkenes with AgNO2/TMSCl...43
Figure 2.1. Generation of Mn(OAc)3 by KMnO4 in the presence of the CH-acidic
precursor.....................................................................................................................46
Figure 2.2. γ-Lactone synthesis by the in situ generation of Mn(OAc)3………..…47
Figure 2.3. Application of in situ generation of Mn(OAc)3 to the α'-acetoxylation of
enones.........................................................................................................................47
Figure 2.4. Oxidation of 1-tetralone 93 to 2-acetoxytetralone 94 via KMnO4/acetic
acid in benzene............................................................................................................51
Figure 2.5. Acyloxylation of enones and aromatic ketones via
KMnO4/RCOOH………………………………………………………………….....53
Figure 2.6. Synthesis of biaryls via KMnO4/CH3COOH system…...........................56
Figure 2.7. Cyclic voltammetry result for KMnO4/acetic acid system....................59
Figure 2.8. Reaction of indene and ethylacetoacetate in the presence of
KMnO4/acetic acid/benzene system……………………….......................................60
Figure 2.9. Synthesis of biaryls and enone oxidation reactions with Mn(OAc)3 under
MW radiation..............................................................................................................64
Figure 2.10. Synthesis of biaryls and enone oxidation reactions with
KMnO4/AcOH/benzene system under MW radiation……………………....………65
Figure 2.11. Ipso-nitration of aryl boronic acids via AgNO2/TMSCl.......................69
Figure 4.1. General reactions of KMnO4/carboxylic acid/organic solvent system…86
Figure 4.2. Ipso-nitration of arylboronic acids..........................................................87
xvi
Figure 4.3 1H-NMR spectrum of 6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-
yl acetate (90)……………………………………………………………..………....99
Figure 4.4 1H-NMR spectrum of 1,2,3,4-Tetrahydro-5,7-dimethyl-1-oxonaphthalen-
2-yl acetate (92)…………………………………………………………………....100
Figure 4.5 13C-NMR spectrum of 1,2,3,4-Tetrahydro-5,7-dimethyl-1-oxonaphthalen-
2-yl acetate (92)………………………………………………………………..…..100
Figure 4.6 1H-NMR spectrum of 3,4-Dihydro-6-methyl-4-oxo-2H-chromen-3-yl
acetate (98)………………………………………………………………………....101
13
Figure 4.7 C-NMR spectrum of 3,4-Dihydro-6-methyl-4-oxo-2H-chromen-3-yl
acetate (98)………………………………………………………………….…..….101
1
Figure 4.8 H-NMR spectrum of 1,2,3,4-Tetrahydro-1-oxonaphthalen-2-yl
propionate (117)…………………………………………………………………....102
13
Figure 4.9 C-NMR spectrum of 1,2,3,4-Tetrahydro-1-oxonaphthalen-2-yl
propionate (117)…………………………………………………………..…….….102
Figure 4.10 1H-NMR spectrum of 4,6,6-Trimethyl-2-oxocyclohex-3-enyl butyrate
(119)………………………………………………………………………..………103
13
Figure 4.11 C-NMR spectrum of 4,6,6-Trimethyl-2-oxocyclohex-3-enyl butyrate
(119)……………………………………………………………………..…………103
Figure 4.12 1H-NMR spectrum of 1,2,3,4-Tetrahydro-1-oxonaphthalen-2-yl formate
(121)……………………………………………………………………………......104
Figure 4.13 13C-NMR spectrum of 1,2,3,4-Tetrahydro-1-oxonaphthalen-2-yl formate
(121)…………………………………………………………………………...…...104
1
Figure 4.14 H-NMR spectrum of 1,2,3,4-Tetrahydro-5,7-dimethyl-1-
oxonaphthalen-2-yl formate (122)………………………………………..……..…105
13
Figure 4.15 C-NMR spectrum of 1,2,3,4-Tetrahydro-5,7-dimethyl-1-
oxonaphthalen-2-yl formate (122)…………………………………………..….….105
Figure 4.16 1H-NMR spectrum of 1,2,3,4-Tetrahydro-6-methoxy-1-oxonaphthalen-
2-yl formate (123)……………………………………………………...……..……106
13
Figure 4.17 C-NMR spectrum of 1,2,3,4-Tetrahydro-6-methoxy-1-oxonaphthalen-
2-yl formate (123)……………………………………………………………...…..106
1
Figure 4.18 H-NMR spectrum of 2-Fluoro-6,7,8,9-tetrahydro-9-oxo-5H-
benzo[7]annulen-8-yl formate (125)………………………………………..……...107
xvii
Figure 4.19 1H-NMR spectrum of 1,2,3,4-Tetrahydro-5-methoxy-1-oxonaphthalen-
2-yl formate (126)………………………………………………………..………...108
13
Figure 4.20 C-NMR spectrum of 1,2,3,4-Tetrahydro-5-methoxy-1-oxonaphthalen-
2-yl formate (126)………………………………….………………………..……..108
Figure 4.21 1H-NMR spectrum of 4-(Trifluoromethoxy)-1,10-biphenyl (142)…...109
Figure 4.22 13C-NMR spectrum of 4-(Trifluoromethoxy)-1,10-biphenyl (142).…109
Figure 4.23 1H-NMR spectrum of Ethyl 2-methyl-4,8b-dihydro-3aH-indeno[1,2-
b]furan-3-carboxylate (157)…………………………………………………..…....110
13
Figure 4.24 C-NMR spectrum of Ethyl 2-methyl-4,8b-dihydro-3aH-indeno[1,2-
b]furan-3-carboxylate (157)……………………………………………………..…110
1
Figure 4.25 H-NMR spectrum of Ethyl 2-ethyl-4,8b-dihydro-3aH-indeno[1,2-
b]furan-3-carboxylate (159)………………………………………………………..111
13
Figure 4.26 C-NMR spectrum of Ethyl 2-ethyl-4,8b-dihydro-3aH-indeno[1,2-
b]furan-3-carboxylate (159)…………………………………………………..……111
Figure 4.27 1H-NMR spectrum of Ethyl 2-isopropyl-4,8b-dihydro-3aH-indeno[1,2-
b]furan-3-carboxylate (161)……………………………………………………..…112
13
Figure 4.28 C-NMR spectrum of Ethyl 2-isopropyl-4,8b-dihydro-3aH-indeno[1,2-
b]furan-3-carboxylate (161)…………………………………………………….….112
Figure 4.29 1H-NMR spectrum of Ethyl 2-phenyl-4,8b-dihydro-3aH-indeno[1,2-
b]furan-3-carboxylate (163)……………………………………………………..…113
13
Figure 4.30 C-NMR spectrum of Ethyl 2-phenyl-4,8b-dihydro-3aH-indeno[1,2-
b]furan-3-carboxylate (163)……………………………………………………..…113
1
Figure 4.31 H-NMR spectrum of ethyl 2-isopropyl-3a-phenyl-3a,4,5,6,7,7a-
hexahydrobenzofuran-3-carboxylate (165)……………………………………..….114
13
Figure 4.32 C-NMR spectrum of ethyl 2-isopropyl-3a-phenyl-3a,4,5,6,7,7a-
hexahydrobenzofuran-3-carboxylate (165)……………………………………..….114
1
Figure 4.33 H-NMR spectrum of ethyl 2,3a-diphenyl-3a,4,5,6,7,7a-
hexahydrobenzofuran-3-carboxylate (166)……………………………………..….115
13
Figure 4.34 C-NMR spectrum of ethyl 2,3a-diphenyl-3a,4,5,6,7,7a-
hexahydrobenzofuran-3-carboxylate (166)………………………………………...115
1
Figure 4.35 H-NMR spectrum of ethyl 2-methyl-3a-phenyl-3a,4,5,6,7,7a-
hexahydrobenzofuran-3-carboxylate (168)……………………………………..….116
xviii
13
Figure 4.36 C-NMR spectrum of ethyl 2-methyl-3a-phenyl-3a,4,5,6,7,7a-
hexahydrobenzofuran-3-carboxylate (168)……………………...………………....116
Figure 4.37 1H-NMR spectrum of 3,5-difluorobiphenyl (169)………………..…..117
Figure 4.38 13C-NMR spectrum of 3,5-difluorobiphenyl (169)……………….…..117
Figure 4.39 1H-NMR spectrum of 2-(3,5-difluorophenyl)thiophene (170)….....…118
Figure 4.40 13C-NMR spectrum of 2-(3,5-difluorophenyl)thiophene (170)………118
1
Figure 4.41 H-NMR spectrum of 2-(4-(trifluoromethoxy)phenyl) thiophene
(171)……………………………………………………………………………..…119
13
Figure 4.42 C-NMR spectrum of 2-(4-(trifluoromethoxy)phenyl) thiophene
(171)……………………………………………………………………………..…119
1
Figure 4.43 H-NMR spectrum of 2-Methoxy-5-(thiophen-2-yl) benzaldehyde
(175)………………………………………………………………...…………..….120
13
Figure 4.44 C-NMR spectrum of 2-Methoxy-5-(thiophen-2-yl) benzaldehyde
(175)……………………………………………………………………………..…120
Figure 4.45 1H-NMR spectrum of ethyl 2,5-dimethyl-5-phenyl-4,5-dihydrofuran-3-
carboxylate (169)………………………………………………………………..…121
xix
CHAPTER 1
INTRODUCTION
In the past two decades, the elaboration of redox methods for the generation of
radicals by the help of transition metal salts and their oxides has become a powerful
impulse for the development of free-radical chemistry. The reactions, mediated by
Mn3+, Co3+, Cu2+, Fe3+, Ag2+, Pb4+, Ce4+, Mn4+, V5+, Ag+, Cu+, Fe2+, and Cr2+ are the
most widely explored1-5. In comparison with traditional methods of radical
generation3,5,6, redox initiators demonstrate remarkable regioselectivity, especially
efficient with polyfunctional organic compounds. Furthermore, new types of
radicals, unachievable by traditional approaches, may be successfully generated. The
main difference is the dual role that the metal oxidants play in the reactions: first,
one-electron oxidation of a carbonyl compound, producing an educt radical and,
second, the oxidative interaction with the intermediate adduct radical, formed by
addition of educt radical to the substrate. This is why the synthetic result of
metalmediated reactions significantly differs from that of peroxide- or light-initiated
processes. Correspondingly, the terminology used reflects the difference in the
essence, i.e. “mediated” or “induced” for metal-participation reactions and “induced”
for non-metal, traditional ones.
Manganese (III) acetate occupies a unique place among metal oxidants, the history of
which, as an effective mediator for the interaction of unsaturated systems with
carbonyl compounds, originates from the Bush and Finkbeiner and Heiba and Dessau
1
studies7,8. In the past three decades, multidimensional extension of this reaction has
taken place, providing a number of novel accesses to different classes of organic
compounds, as well as bringing an improved understanding of the nature of the
process9.
2
O O
C C H + Mn(III) C C + Mn(II) + H
O O
C C + C C C C C C
Figure 1.1. Addition reaction to olefinic systems in the presence of manganese (III)
acetate
The fate of the primary adduct radical strongly depends on reaction conditions and
the nature of the substrate. Substances that are less reactive to common oxidants are
more interesting since here the unique properties of manganese (III) acetate as a free
radical generator can be more fully exploited. Mn(III) bears many similarities with
respect to a given substrate class with other one-electron oxidants like Co(III),
Ce(IV), and some two-electron oxidants like Tl(III) and Pb(IV). It is often observed
that owing to its lower reactivity, higher selectivities can be obtained with
manganese (III) acetate as compared with other oxidizing agents. Many of these
reactions proceed according to the simplified scheme shown below (Figure 1.2).
Figure 1.2. General reaction pattern for indirect oxidation mechanism of manganese
(III) acetate
3
1.2.2. Synthesis and Properties of Manganese (III) Acetate
Although a great amount of work has been done using manganese (III) acetate as an
oxidizing agent, relatively little is known of the compound itself. Basically two
forms are to be distinguished:
Since many oxidations with manganese (III) species are known to be influenced by
small amounts of water, the latter form is preferred by many workers, especially for
kinetic work. Moreover, small amounts of water cause disproportionation of Mn(III)
acetate in glacial acetic acid. In acetic acid-water mixtures containing large amounts
of water, manganese (III) acetate hydrolyzes slowly to mixtures Mn(OH)3 and MnO2.
Both the hydrated and anhydrous forms have been made in various ways10. Many
workers introduced special modifications, which certainly have affected the chemical
composition and reactivity of the anhydrous form. In Table 1, the most important
routes to manganese (III) acetate are given.
4
The solubility of manganese (III) acetate in acetic acid depends on the synthetic
procedure used and the water content of the acetic acid. The compound should be
dissolved by gentle heating. Table 2 gives some pertinent results.
Since the dihydrate dissolves poorly in water containing acetic acid, the anhydrous
form is soluble in such systems only in a very limited range.
5
autooxidation from the ketone, is bound by both Mn(II) and Mn(III) acetate. These
mixed acetate-formate complexes are less soluble in the medium used than
manganese (III) acetate proper.
The crystal structure of anhydrous manganese (III) acetate was studied by Hessel and
Romers16-21. These authors assume a linear polymer with empirical Formula
[Mn3O(OAc)6.AcOH.OAc]n. In the monomer unit, three manganese are connected by
three pairs of acetate bridges and form an equilateral triangle with an oxygen atom in
its center. Acetic acid molecules and acetate bridges between the monomer units
complete the distorted octahedral coordination of the manganese atoms. In solution, a
molecular weight of 640±75 is found16 and as best representation the following
structure is proposed:
[Mn3O(OAc)6.3AcOH]+ [OAc]-
Here the octahedral coordination of the manganese atoms in the trinuclear complex is
completed by three acetic acid molecules. Anhydrous manganese (III) acetate
dissolves slowly in most solvents at room temperature. It can be dissolved in many
solvents without appreciable reduction by gentle warming. Examples are ethanol,
pyridine, and to some extent benzene and chloroform. It reacts at relatively low
temperatures (70oC) with enolizable solvents such as acetone or methyl ethyl ketone,
but is less reactive with simple esters like ethyl acetate. It is hardly soluble in
acetonitrile and petroleum ether and decomposes in water. It exchanges acetate for
carboxylic acid when dissolved in such acids2.
6
The chemical constitution of the dihydrate comes close to Mn(OAc)3.2H2O. The
solubility of the dihydrate in common solvents is similar to that of the anhydrous
Form16,23.
One of the more outstanding reactions initiated by manganese (III) acetate found by
Bush and Finkbeiner7 and Heiba and Dessau8 is the oxidative addition of carboxylic
acids to olefins leading to γ-butyrolactones. This reaction has been proven to be
generally applicable, as exemplified by many workers, although lactones are not
always major products.
OH R
1 3
Mn(OAc)3
R
4
7
This sequence of steps generates a radical oxidatively from acetic acid, efficiently
forms a carbon-carbon bond, and produces a synthetically useful γ-lactone by
oxidation of the carbon-centered radical. Unfortunately, Mn(III)-based oxidative
cyclization of unsaturated acids is not possible, since the optimal solvent for this
reaction, acetic acid, will be oxidized preferentially24.
The course of the reaction and the formation of other major products depend largely
on the nature of the substrate olefin, reacting acid, and on reaction conditions. There
is now general agreement on the mechanism of this reaction together with its main
side reactions. The major reactions involved in the Mn(III) acetate initiated addition
of acetic acid to an α-olefin in acetic anhydride-acetic acid mixtures are given in
figure 1.4 and 1.525.
O O O O O
+ Mn(OAc)3 + + Mn(OAc)2
O O OH
H O O O O
CH 2 +
R O O
H
8
O O
acetic anhydride O O
O + O
O O H
O O
CH 2
O R O Telomer acids
H
R R
R
O O
Mn(III) O
H
loss of H
intramolecular
cyclization to
Reaction with solvent γ− lactones
to γ− acetoxy acid
R
O O O O
O O
O O
+ O
O H O
O
R
O R R'
Figure 1.5. Mn(III) acetate initiated addition of acetic acid to an α-olefin in acetic
anhydride-acetic acid mixtures
From this mechanistic view, the following basic requirements for oxidative addition
can be drawn:
9
RCOO.. In the presence of excess anhydride, carboxyalkyl radical formation
is favored and a larger variety of acids can be used25,27.
H H H O
2 2
R C C C
O
H3C
O
5
CH 3COOH R1 R3 4
R1 R3 R2 R
6
Mn(OAc) 3 O
R2 R4
8
O
HO CHR 5R 6 R1 R3 4
R1 R3 R 2 R
7
R2 R4 O R5
Mn(OAc) 3 6
R
8
O
11
1.2.6. Mn(III) Acetate-Initiated Addition of Aldehydes to Olefinic Unsaturated
Systems
Most free radical additions of aldehydes to olefins yield ketones as main products.
Thus the peroxide, γ-radiation, and oxygen initiated addition of aldehydes to 1-
alkenes provide a convenient method for the synthesis of ketones. The acyl radical
R−Ç=O is believed to be formed as an intermediate in these systems. In the presence
of manganese (III) acetate, a free radical addition of aldehydes to olefins is also
observed. However, depending on reaction conditions, both the expected ketones and
rather unexpected aldehydes can be formed. The primary intermediate from the
interaction of manganese (III) acetate and the aldehyde is the formylalkyl radical 9
33
.
H O
R C
H
9
12
O
O O O
R
R Mn(III) R H R
H H
O O chain
+ R1 transfer saturated
R R1 R ketone
O O chain
+ transfer saturated
R R1 R1 H
H aldehyde
R
10
O O
Cu(II) or Mn(III) R1
R1 H H
R R
O
H
R
R1
O O
Mn(III)
R1 H R1 H
R OAc R
O
O O
R saturated
H R + aldehyde
R1 H
R
Organic peroxides and γ-radiation have been used to initiate the radical addition of
ketones to olefins, although surprisingly little on such reactions is reported in the
literature. The one-electron oxidation of enolizable ketones by manganese (III)
acetate has offered a new and convenient method for the generation of α-oxo alkyl
radicals37,38 useful in a number of synthetic routes to saturated and unsaturated
13
ketones, substituted dihydrofurans, tetralones, and diketones. Although yields in
most cases are only moderate, this reaction may still be the method of choice when
the substrate olefins and ketones are readily available. Reactions have been
performed with a great variety of ketones and olefins. The reactions are generally
accelerated by addition of acetic acid, although product patterns may change. In the
presence of Cu(II) acetate, unsaturated adducts are formed.
O O
R1
+ R1
R R
11 12 13
Mn(III)
O
R1
R
OAc
14
Figure 1.11. Addition of simple ketones to olefins in the presence of manganese (III)
acetate
14
When saturated adducts are the products of choice and a fast reaction is wanted, such
reactions can best be performed by slowly adding manganese (III) acetate, to obviate
oxidation products, and olefin, to suppress telomerization to the ketone. The effect of
the structure of α-oxo-alkyl-radical on rate of addition to unsaturated systems was
clearly demonstrated by Vinogradov39, primary radicals 15 adding more readily on
alkenes and alkynes than secondary 16 and tertiary radicals 17.
O O O
H > H >> R
H R R
15 16 17
15
O
O Mn(III) O Ph 18 Ph
21
19 20
M n(III)
O
−H
Ph
Ph O
23 22
From this scheme, it can be rationalized that higher yields can be obtained with:
1. Readily oxidizable ketones like β-diketones.
2. Olefins with a vinylidene structure like α-methylstyrene and isobutylene.
The reaction products with terminal olefins in all cases have consisted of only one
isomer. The corresponding reactions of Tl(III) and Pb(IV) acetate have reportedly led
to other isomers or mixtures of isomers and probably via ionic mechanisms.
Heiba and Dessau have reported in 1974 that β-keto esters and related dicarbonyl
compounds are oxidized to radicals at 25-70°C in acetic acid24. The application of
Mn(III) to oxidative free-radical cyclizations was investigated initially by Corey,
Fristad, and Snider. Corey and Kang have reported the oxidative cyclization of
unsaturated β-keto acids in 198440. In 1985, Snider41 has described the oxidative
16
cyclization of unsaturated β-keto esters42 and Fristad has surveyed the cyclization of
unsaturated malonic and cyanoacetic acids43. For instance, oxidation of ethyl
acetoacetate 24 in the presence of styrene 25 affords a dihydrofuran 26 which was
reported by Heiba et.al. (Figure 1.14)24.
Ph
O O Mn(OAc)3 O O O O
AcOH 25
OEt OEt OEt
H H 45oC H
24
Ph
M n(OAc) 3
OEt
O
Ph
26
It follows from this reaction scheme that side products to be expected are:
1. Saturated linear ketones derived from chain transfer of the intermediate
adduct radical; these can be suppressed by working at low acetophenone
concentrations.
2. Unsaturated linear ketones and linear keto acetates from oxidation of the
intermediate adduct radical.
17
O O
Mn(III)
27 R
10
O
internal O
cyclization R
H
R
Mn(III)
R
28
Enol acetates as unsaturated substrates have been used in reactions with aliphatic45
and terpenoic46 ketones, resulting in access to 1,4-diketones, key intermediates in
cyclopentenone synthesis.
18
O O
M n(III)
R R
29 OAc
30
O O
OAc
R R
O
31
OAc
O O O
30
OAc O
Mn(OAc)3
AcOH
32 70 oC, 10 min. 33 34
19
1.2.8. Aromatic Substitution Reactions
The substitution reactions of this type require two equivalents of manganese (III)
acetate as exemplified by the following reaction scheme for the substitution of
acetone 16 to benzene 35 (Figure 1.18).
O O
+ Mn(OAc)3 + AcOH + Mn(OAc)2
16
O H
+
35 O
H
+ Mn(OAc)3
O O
+ AcOH + Mn(OAc)2
20
1.2.9. Mn(OAc)3 Mediated Biaryl Coupling Reactions
C-C bond-forming reactions leading to biaryls are very important because this
approach is the key step in the synthesis of many natural and unnatural biaryls. There
are various biaryl coupling methods, and the applications of these methods are
reviewed comprehensively in the literature. A common method for the synthesis of
simple unsymmetrical biaryls is the generation of aryl radicals in the presence of
aromatic solvents. Although the product range of this approach is somewhat limited,
it provides an easy access to a variety of unsymmetrical biaryls. Demir et.al. have
recently shown that arylhydrazines 36 can be efficiently oxidized by manganese(III)
acetate to produce aryl radicals that afford biaryls 37 in benzene with very good
yields as shown in Figure 1.19 47.
NHNH 2 .HCl
Mn(OAc)3
R R
36 37
21
nitrate) furnished a mixture of products. The major fractions were identified as
biphenyl 37 and azobenzene 38 (3:2 respectively). In addition to these compounds,
complex mixtures of terphenyl isomers and azobenzene derivatives of biphenyls
were detected by GC-MS. The isolated yields of products were very low and in all
cases there were unidentifiable products.
N
N
N O
N
O
38 39 40
Mn(III) acetate is more selective and effective than Co(III), Ce(IV) and Pb(IV).
Selectivities can be attributed to the slow formation of radicals with Mn(III) acetate.
Co(III), Ce(IV) and Pb(IV) compounds are more powerful oxidants, and therefore
less selective.
22
ArNHNH 2 + Mn(III) (ArNHNH2) + Mn(II)
(ArNHNH2 ) (ArNHNH) + H
(ArNHNH) ArN NH + H
ArN NH Ar + N 2 + H
This study has shown that it is possible to oxidize arylhydrazines with Mn(III)
acetate in benzene to form the corresponding phenyl-substituted benzene derivatives
in good yield; access to biaryls works selectively, and coupling occurs where
hydrazine departs. Using substituted benzenes as solvents furnishes isomeric
mixtures of the corresponding biaryls.
Although the reaction is very efficient in benzene, Demir et.al. have also shown that
it generally produces the corresponding heterobiaryls from arylhydrazines 36 in
furan 41 and thiophene 42 with moderate to good yields (Figure 1.22) 49.
NHNH 2 .HCl
X
Mn(OAc)3
R X R
36 41 X=O
42 X=S
This drawback of arylhydrazines prompted the same group to find a more suitable
substrate as the source of aryl radicals. A suitable candidate for this reaction should
23
be much more reactive than arylhydrazinium salts under the reaction conditions yet
stable enough to handle easily and not prone to side reactions. It is known that
arylboronic acids decompose to aryl radicals in the presence of some oxidants50.
Arylboronic acids are widely used as the organometallic counterpart in the Suzuki
reaction. They are stable under atmospheric and aqueous conditions such that Suzuki
coupling can be carried out with aqueous organic solvents. Therefore, Demir et.al.
decided to investigate the oxidation of arylboronic acids with manganese(III) acetate
in aromatic solvents and reported the synthesis of a variety of unsymmetrical biaryls
36 with in situ generated aryl radicals from arylboronic acids 43 with manganese
(III) acetate as shown in Figure 1.23 51.
B(OH)2
Mn(OAc)3
R R
43 37
The yields were generally better than those from similar reactions reported
previously. This had shown that arylboronic acids are suitable substrates for the
generation of aryl radicals. This study has shown that a variety of radicals can be
generated from the corresponding arylboronic acids. In the presence of organic
solvents, these radicals afford the monosubstituted biaryls with yields generally
higher than those from similar previously reported reactions. Reactions in benzene
gave higher yields than those in furan 41 or thiophene 42; the former was better in
terms of yield (Figure 1.24).
24
B(OH)2
X
Mn(OAc)3
R X R
43 41 X=O
42 X=S
25
MnIII
O O O
CO2 Me Mn(OAc)3 CO2 Me
CO2 Me
AcOH R= Me
H R R R
20-50o C
R=H
O O O
R solvent R R
CO 2Me or CO 2Me Cu(OAc)2 CO 2Me
44a R=H
H 44b R=Me H
H
45a R=H 46a (71%)
49 46b (56%)
45b R=Me
Figure 1.25. Tandem oxidative cyclizations with various Mn(III) reagents and
Cu(OAc)2
The first step in the reaction is the loss of a proton to give the Mn(III) enolate 47.
The next step of the reaction could involve cyclization of the unsaturated Mn(III)
enolate 47 to give cyclic radical 45a. This is the operative pathway for R=H.
Alternatively, loss of Mn(II) could give the Mn-free free radical 48b. This is the
operative pathway for R=Me. Cyclization of 48b from the conformation shown gives
radical 45b stereo- and regiospecifically. Finally, Cu(II) oxidation of 45a and 45b
gives 46a and 46b regio- and stereospecifically.
Snider et.al. have examined the tandem oxidative cyclization of 50 with various
Mn(III) reagents and Cu(OAc)254. Oxidative cyclization with Mn(OAc)3 and
Cu(OAc)2 affords 86% of 51 and 0% of 52, while use of Mn(pic)3
(manganese(III)picolinate) and Cu(OAc)2 leads to 0% of 51 and 15% of 52. A series
of control experiments established that the most likely explanation for this
observation is that Mn(pic)3, but not Mn(OAc)2, reacts with the bicyclic radical 53
more rapidly than Cu(OAc)2 does. This illustrates a general feature of oxidative
26
radical cyclizations. A one-electron oxidant, e.g., Mn(III), Cu(II), Ce(IV), etc., is
needed for both the generation of the acyclic radical and oxidation of the cyclic
radical. Furthermore, the lower valent metal salt produced in these oxidations must
not react rapidly with any of the radical intermediates. Mn(pic)3 does not meet these
requirements, since Mn(pic)2 reacts with the cyclic radical more rapidly than
Cu(OAc)2 does; the alkyl Mn(pic)2 intermediate produced in this reaction apparently
abstracts a hydrogen giving reduced products such as 52 (Figure 1.26).
O
CO2Me
Mn(OAc)3
Cu(OAc)2
O O
MnIII CO2Me
Cu(OAc)2 51 (86%)
CO2 Me
Mn(pic)3
Cu(OAc) 2 O
50 53 CO2Me
52 (15%)
Figure 1.26. Tandem oxidative cyclization of 50 with various Mn(III) reagents and
Cu(OAc)2
27
1.2.11. Mn(III) Acetate Mediated Oxidation of α,β-Unsaturated Ketones
O O
Mn(OAc) 3 O R'
RCOOH O
54 55
56-61
Demir et.al. have comprehensively developed the α'-oxidation of enones to α'-
acyloxyenones discovered by Hunter62. During the course of this work they have
found that a wide variety of manganese (III) carboxylates could be prepared from
Mn(OAc)3 and the carboxylic acid in situ and used for α'-acyloxylation of enones
and aryl alkyl ketones56-61. The utility of these manganese(III) carboxylates in
oxidative free-radical cyclizations has not been examined.
57
Demir et.al. have reported the extension of the oxidation process discovered by
62
Hunter to cyclic β-alkoxy- α,β-unsaturated ketones 56, which exhibits the same
regiochemical preference for oxidation at the α'-position to afford the α'-acyloxy- β-
alkoxy-α,β-unsaturated ketones 57 in good yield (Figure 1.28). These α'-acyloxy- β-
alkoxy- α,β-unsaturated ketones 57 are useful intermediates in the synthesis of
63-71
natural products , and general procedures for the synthesis of 55 are either not
available or involve multiple steps.
28
The conversion of cyclic β-diketones 58 to the β-alkoxy- α,β-unsaturated ketones 56
72
and the oxidation of 56 using six equivalents of manganese (III) acetate73 in
combination with twelve equivalents of a carboxylic acid led to the α'-acyloxy- α,β-
unsaturated ketones 57 in good yield. As in previous studies 56, the use of manganese
(III) acetate as the sole oxidant was not successful, suggesting that an initial reaction
between the manganese (III) acetate and the carboxylic acid led to an active “mixed”
manganese (III) complex having both acetate and other carboxylate ligands. The
interaction of the enol or enolate of 56 with this mixed manganese (III) complex
presumably furnished the desired product 57. Since the reduction and hydrolysis of
α-acyloxy- β-alkoxy- α,β-unsaturated ketones provided access to γ- hydroxy- α,β-
unsaturated ketones as exemplified in the case of (S)-6-Acetoxy-3-methoxy-2-
methyl-2-cyclohexen-1-one 59 (Figure 1.28), this process extended the utility of the
manganese (III) oxidation procedure to the oxidation of α,β-unsaturated ketones at
either the α'-or γ-positions.
O O O
Mn(OAc)3
MeOH RCOOH O R
benzene O
O MeO reflux, 20-48 hr MeO
58 56 57
68-78%
O
OAc OH
* 1. LiAlH 4/Et2 O *
MeO 2. aq. H 2SO4 O
59
79%
29
56
Demir et.al. have demonstrated the synthesis of α'-acyloxy enones 55 either from
enones 54 using manganese (III) acetate in combination with either manganese (II)
carboxylates or carboxylic acids.
O Mn(OAc)3
O
O R
Mn(OCOR)2
benzene O
54 55
30
O O
Mn(OAc)3
O R
RCOOH
benzene O
54 55
31
Mn III O AcO- Mn III O
III CH3 III CH2
Mn O Mn O
Mn III O slow MnIII O
60 61
fast
Mn III O
Mn III
O
R Mn III O
III CH2
Mn II O Mn O
R MnII O
63 62
Snider have found that a similar mechanism is operative in the oxidation of α-alkyl
β-keto esters 64 (Figure 1.32) 83.
32
M nIII
O O O O O
Mn(OAc)3 Me f ast
OR OR
H Me Me
slow O OR
64 65 66
R
fast
O O
OR
Me
R
67
On the other hand, Snider have found that the enolization of α-unsubstituted β-keto
esters 68 is fast and reversible, and electron transfer to give the radical is very slow
(Figure 1.33) 83.
M nIII
O O O O O
Mn(OAc)3 H R
OR OR
H H f ast slow H
O OR R
68 69 70
33
step, the length of the tether should, and does, affect the rate of oxidative cyclization
of unsaturated β-keto esters. 6-exo-cyclization is more rapid than 5-exocyclization 83.
The nature of the tether also affects the rate of oxidative cyclization of unsaturated β-
keto acids 40.
A methyl group should slow down the formation of Mn(III) enolate 65, since it is
electron donating and decreases the acidity of the α-proton which is responsible for
the change in the mechanism. On the other hand, the methyl group should facilitate
the oxidation of 65 to 66 since it will stabilize the radical. Electrochemical data for
the oxidation of enolates of β-dicarbonyl compounds to the radical in DMSO support
this hypothesis. The nature of the reaction depends on two variables: the rate of
formation of the Mn(III) enolate, which corresponds to the pKa, and the ease of
oxidation of the enolate to give a free radical. For most compounds enolization is the
rate-determining step. For very acidic compounds such as α-unsubstituted β-keto
esters and β-diketones, enolization occurs readily and oxidation is slow.
Commercially available Mn(OAc)3.2H2O has been used for the majority of oxidative
cyclizations. Anhydrous Mn(OAc)3 is slightly more reactive than the dihydrate.
Reaction times with the anhydrous reagent are usually somewhat shorter but the
yields of products are usually comparable. Both trifluoroacetic acid and potassium or
sodium acetate have been used with Mn(OAc)3. Use of trifluoroacetic acid as a
cosolvent usually increases the rate of the reaction, but often decreases the yield of
products. Acetate anion may accelerate enolization and act as a buffer. Acetic acid is
the usual solvent for Mn(OAc)3.2H2O reactions. DMSO, ethanol, methanol, dioxane,
and acetonitrile can also be used, although higher reaction temperatures are required
and lower yields of products are sometimes obtained. The use of ethanol can be
advantageous in cyclizations to alkynes. Vinyl radicals formed by cyclization to
alkynes are not readily oxidized by Mn(III) and will undergo undesired side reactions
unless there is a good hydrogen donor available. Ethanol acts as a hydrogen donor,
reducing the vinyl radical to an alkene and giving the α-hydroxyethyl radical, which
is oxidized to acetaldehyde by Mn(III). Much higher yields of alkenes are obtained
from cyclizations to alkynes in ethanol than in acetic acid 84.
34
Mn(OAc)3.2H2O is not particularly expensive on a laboratory scale, but its use on an
industrial scale may be problematic. Several groups have demonstrated that Mn(III)
85-89
can be used in catalytic quantities and regenerated electrochemically in situ . In
some cases, good yields of products are obtained with only 0.2 equiv (10%) of
Mn(III) or Mn(II). In other cases the electrochemically mediated reactions proceed in
substantially lower yield or give different products. D’Annibale and Trogolo have
reported that improved yields are obtained in some Mn(III) and Ce(IV) based
oxidative cyclizations and additions if they are carried out with ultrasound irradiation
90-92
.
R
O
- Mn II
O R
Mn III O
III
Mn O MnIII O
72
Mn II O
R O
63 71
MnIV R - Mn II
O
O
73
35
Addition of 1,3-dicarbonyl compounds to alkenes affords isolated radicals that do not
contain a proximal manganese carboxylate, e.g., 46 and 53. Mn(III) will oxidize
tertiary radicals to cations that can lose a proton to give an alkene or react with
solvent to give a tertiary acetate. Mn(III) will also oxidize allylic radicals to allylic
acetates and cyclohexadienyl radicals, resulting from addition to aromatic rings, to
the cation, which loses a proton to regenerate the aromatic system.
Mn(III) does not oxidize primary radicals such as 53 or secondary radicals such as
46. If no cooxidant is used, hydrogen abstraction is the major pathway 41. Mn(OAc)3
is also involved in the termination step. It rapidly oxidizes tertiary radicals to cations
that lose a proton to give an alkene or react with acetic acid to give acetate esters.
Mn(OAc)3 oxidizes allylic radicals to allylic acetates and oxidizes cyclohexadienyl
radicals generated by additions to benzene rings to cations that lose a proton to
regenerate the aromatic system. On the other hand, Mn(OAc)3 oxidizes primary and
secondary radicals slowly, so that hydrogen atom abstraction from solvent or starting
material becomes the predominant process. Alkenes are formed efficiently from
primary and secondary radicals by use of Cu(OAc)2 as a cooxidant 41.
One can envisage several mechanisms for oxidation of the enones to the α'-
acetoxyenones. For example, the formation of a metal enolate with acetate transfer
(Figure 1.35) analogous to the lead tetraacetate oxidation of enones is possible.
36
OAc
Mn
O O
O
Mn(OAc) 3
74
O
O O
75
Figure 1.35. Suggested enolate mechanism for oxidation of enones to the α'-
acetoxyenones with Mn(OAc)3
37
O O
Mn(OAc) 3
74 76
Mn(OAc)3
ligand
transfer
O
O O
75
Figure 1.36. Suggested radicalic mechanism for oxidation of enones to the α'-
acetoxyenones with Mn(OAc)3
38
AcOH shortened the reaction time and increased the yields. The role of acetic acid
could be related to an increased solubility of Mn(OAc)3 in the reaction mixture. From
a synthetic point of view, excellent results were obtained for a variety of structurally
and synthetically important enones under optimized conditions. Although benzene
was the most frequently used solvent it was also reported that cyclohexane and MeCN
could also be used instead of benzene, and acetic anhydride could be used instead of
acetic acid.
O O
Mn(OAc)3
O
O
benzene/AcOH (10:1)
reflux
54 55
Figure 1.37. Improved procedure based on the use of acetic acid as a co-solvent
Although arylboronic acids93 have been available for more than one hundred years,
they have not been used much in organic synthesis until recently. Since they are
comparatively stable compounds they have a wide range of applications in organic
synthesis44.
94-96
Aromatic substitution reactions have been investigated extensively . When an
electrophile attacks a substituted aromatic ring directly at the position bearing the
substituent, the attack is termed ipso-attack 95,98,99.
Nitration of aromatic compounds is one of the most widely studied reactions and an
immensely important industrial process. Nitroarenes play important roles as
39
precursors to industrial products, which has led to a very good understanding of the
steps involved in the nitration reaction 100-103.
For the nitration of arylboronic acids two important works are published. In earlier
studies, Prakash et al. have shown regeoselective nitration of arylboronic acids with
Crivello’s reagent (ammonium nitrate/ trifluroacetic anhydride) (Figure 1.48) 112.
42 77 78
40
However, during nitration with the relatively powerful Crivello’s reagent, dinitration
was also observed and the temperature had to be carefully regulated to avoid
undesirable side reactions.
Figure 1.39. Ipso-nitration of arylboronic acids using inorganic nitrate salt and
chlorotrimethylsilane
The suggested mechanism for the regioselective nitration of arylboronic acid carried
out with AgNO3/TMSCl was that TMS-Cl reacts with nitrate salts to generate the
TMS-O-NO2 species. The electronic interaction between the boronic acid group and
the intermediate active nitrating agent TMS-O-NO2 species through boron and the
siloxy group due to the high oxophilicity of boron (Figure 1.40) helps the nitration
to occur at the ipso position.
41
(H 3 C) 3Si Cl + M(NO3 )x (H 3C) 3Si O NO2 + MClx
(H 3 C) 3Si Cl
OH HO OH Si(CH 3) 3
HO
B B O
Si(CH 3) 3 NO 2
+ O
NO2
79
NO2
80
The reaction of dinitrogen trioxide, prepared either from concentrated sulphuric acid
and sodium nitrite or from nitric oxide and air, with olefins affords 1,2-nitronitroso
dimers, commonly referred to as pseudonitrosites. These adducts can be converted to
the most soluble isomer, the corresponding 1,2-nitroximes 116.
According to the work done by Demir et. al., the reaction of AgNO2 with TMSCl
117
affords N2O3 . The addition of N2O3 to alkenes proceeds nitroso nitrate 82, which
are then converted into corresponding α-nitro ketones 83 and followed by cyclization
into furoxans 84 in good yields. This work offers simple and effective method for
the synthesis of furoxans (Figure 1.41).
O
NO2 N
AgNO 2, Me3SiCl H+, heat O
NO N
CH 3CN 2
81 82 84
DMF,
heat H+, heat
NO 2
N
83 OH
The aim of this work was first to prepare trimethylsilyl nitrite from AgNO2 and
TMSCl. Then addition of trimethylsilyl nitrite (as NO+ and –OSiMe3 species) to
alkenes to obtain the corresponding α-hydroxy oximes, it means direct conversion of
43
alkenes to α-hydroxy ketones, which are valuble intermediate in synthetic organic
chemistry 115,116.
The structure of the products showed no evidence for the accepted products 1,2-
hydroxyoxime via addition of trimethylsilylnitrite (NO+ and –OSiMe3) to the double
bounds.
In the literature similar products are obtained by the addition of N2O3 to the alkenes.
For finding evidence for the possible formation of N2O3 and addition to double bond
the TMSCl and silver nitrite are suspended in deuterated DMF at –5oC. The 1H NMR
spectrum showed the formation of hexamethyldisiloxane. With this result it’s
suggested that the reaction of AgNO2 with TMSCl leads the formation of N2O3 and
hexamethyldisiloxane. The formation and subsequent addition of N2O3 to alkene
furnished nitroso nitrate as dimer. Heating of dimeric nitroso nitrate affords
furoxan via formation of α-nitro oxime followed by elimination of water.
Although C-C-and C-O bond formation reactions of a great variety of substrates have
been reported so far by us and others as successful, there are some problems
associated with the use of Mn(OAc)3. A brief list of them is as follows: (1) excess
Mn(OAc)3 (4–6 equiv.) is generally used for acceptable yields and reaction times; (2)
44
many contradictory results can be seen when the literature reports are closely
inspected. These include the amount of Mn(OAc)3 that was employed to carry out
the desired conversion, in which irreproducible yields/reaction times were observed
under the same set of conditions and in reaching its maximum potential shows great
importance from a synthetic and economic point of view. In the first part of the
thesis, we aimed to find and apply a new, simple and more convenient method which
will replace Mn(OAc)3.
45
CHAPTER 2
There are two examples to the in situ generation of Mn(OAc)3 in the literature. In the
first example, Linker and coworkers performed the synthesis of manganese(III)
acetate by the oxidation of Mn(OAc)2 with potassium permanganate which is a well-
known process 118. Their approach was based on the in situ generation of Mn(OAc)3
by KMnO4 in the presence of the CH-acidic precursor 85 (Figure 2.1). Only catalytic
amounts of manganese(III) are involved in this reaction cycle, which allows the
generation of the radicals 86 under ‘non-oxidative conditions’.
O
''KMnO '' Mn(OAc)3
4 R1
R2
85
H
KMnO 4 Mn(OAc)2 + O
R1
R2
+ OAc
86
46
The second example is the γ-lactone synthesis by the in situ generation of Mn(OAc)3
with potassium permanganate and manganous acetate tetrahydrate or dihydrate
(Figure 2.2)119.
R1 R3
R1 R3 R5 OH Mn(III) R2 R4
+ R5
O
R2 R4 R6 O R6
O
There are no examples to the application of in situ generation of Mn(OAc)3 to the α'-
acetoxylation of enones. Therefore we applied this system to this type of reactions.
As the model substrate 1-indanone 87 was selected and its reaction with Mn(OAc)2/
KMnO4/acetic acid system is investigated. In an initial reaction Mn(OAc)2 and
KMnO4 is dissolved in acetic acid and benzene (10:1). This solution is refluxed
under Dean-Stark trap until the color of the solution turned brown. Then, 1-indanone
was added to this solution and reflux was continued. The reaction is monitored by
TLC, and then filtered and neutralized with NaHCO3. After work-up, 2-
acetoxyindanone 88 was isolated with 87% yield (Figure 2.3).
O Mn(OAc)2.2H2O O
KMnO4, AcOH
O
benzene/AcOH (10:1) O
reflux
87 88
47
The same system is applied to other enone commercially available aromatic ketones
and α'-acetoxy products are obtained with good to moderate yields which are
summarized in Table 3.
O 87
O
87
88
O O
O
88
O
O O
89 90
O O
O
95
O
91 92
O O
O
92
O
93 94
O O
O
79
O
O O
95 96
48
Table 3 cont’d
O O
O
84
O
O O
97 98
O O
O O O 65
O
99 100
O O
O 57
O
O O
101 102
49
2.2. KMnO4 / carboxylic acid/ organic solvent system
Although C–C and C–O bond formation reactions of a great variety of substrates
have been reported so far by Demir et. al. and others as successful there are some
problems associated with the use of Mn(OAc)3 are described before42. A brief list of
them is as follows: (1) excess Mn(OAc)3 (4–6 equiv) is generally used for acceptable
yields and reaction times; (2) many contradictory results can be seen when the
literature reports are closely inspected. These include the amount of Mn(OAc)3 and
irreproducible yields/reaction times. After the investigation of the oxidation with in
situ generated Mn(III)acetate from Mn(II)acetate, we investigated the possibility to
generate Mn(III)acetate directly from KMnO4 and acetic acid.
2.2.1 KMnO4 / carboxylic acid/ organic solvent system for enone oxidations.
For optimization studies, several solvents are tried in the reaction such as benzene,
acetonitrile, THF, DMF, cyclohexane and DCM. Best results are obtained with
benzene. In order to determine the sufficient amount of the reactants, the reaction is
performed with 1, 2, 3, and 4 equivalents of KMnO4. 3 equivalent of KMnO4 was the
most efficient for the full conversion. With these optimized conditions, reaction
furnished 94 in 89% yield.
50
O O
KMnO 4/AcOH O
benzene, reflux
O
93 94
Using this procedure, several enones and aromatic ketones were converted into their
acetoxy derivatives as shown in Table 4. The reactions work with the same
regioselectivity. The yields are comparable to the Mn(OAc)3-mediated direct
oxidation of ketones and tolerate many sensitive functional groups. Most of the
starting materials are commercially available and the ketones 99, 107, 109, 111 were
synthesized according to the literature procedure120.
Simple cyclic enones, protected 1,3-diketones and steroid structure containing enone
systems in a ring gives the products in excellent yields. The compounds 91, 97, 103,
105 gives no or trace amount of oxidation products. Only unreacted starting materials
are isolated. Changing the solvent, reaction temperature etc. gives again no product.
93 94
O O
OAc
85 9742
MeO MeO
89 90
51
Table 4 cont’d
O O
OAc
96 -
91 92
O O
OAc 81 -
O O
103 104
O O
OAc
83 -
O O
97 98
O O
F F OAc
74 -
O O
105 106
O O
OAc
97 87120
MeO MeO
107 108
O O
OAc
75 8856b
MeO MeO
109 110
O O
OAc
86 9942
111 112
(CH2)3 (CH2)3
AcO
84 9842
O
O
114
113
52
Table 4 cont’d
O O
OCH3 AcO OCH3
88 88121
99 100
These results prompted us to try an oxidation reaction with carboxylic acid other than
acetic acid, wherein we found that this method can in fact be applied for the
acyloxylation of enones and aromatic ketones in high yields as shown in Table 5
(Figure 2.5).
KMnO 4,
O O
carboxylic acids
R R O O
(n) Benzene (n) R''
R' Reflux R'
115 116
O
93 O O O 87 -
OH
117
Cl O
93 O O O 91 67122
OH
Cl
118
53
Table 5 cont’d
O
111 O O O 82 -
OH
119
O
O O 80 98123
87 O
H OH
120
O
O O O 85 -
93
H OH
121
O
O O O
91 75 -
H OH
122
O O
O O
H OH
89 76 -
O
123
O O O
F O O
F
61 -
H OH
125
124
O
O O O
95 70 -
H OH
O
126
O O
O O 65 89124
OH
93
Ph
127
The reaction tolerates several liquid carboxylic acids which have functional groups
such as chloride. For the first time, formyloxylation was carried out with formic acid.
54
In the literature, rather few works have been presented about the direct
formyloxylation of ketones (Lee et al. reported that an initial treatment of ketones
with thallium(III) triflate, formed in situ by the reaction of thallium(III) acetate with
trifluoromethanesulfonic acid, in DMF at 60 oC followed by the addition of small
amounts of H2O provided the formyloxy ketones)123. The spectroscopic data (1H-
13
NMR, C-NMR) are in aggrement with the structures. The typical peaks in the 1H-
NMR spectrum are the CH proton at 5-6 ppm and H of the formyloxy group which is
around 8 ppm. The products are obtained with excellent yields being independent of
the ring size and functional groups of the enone systems. 5,6 and 7 membered ring
systems gave the corresponding α-acetoxy products in good yields.
Problems occurred when using some solid carboxylic acids, these reactions were
carried out without benzene, wherein only acetic acid was used as a solvent and the
corresponding acyloxy derivatives were synthesized in good yield. By using benzoic
acid, the product was isolated along with an acetoxy derivative as a minor product. It
was possible then to separate the product by column chromatography. No product
formation was observed by using chloroacetic acid, even when we used cyclohexane
and DMF as a solvent.
Recently, Demir et. al. developed a general method for the synthesis of biaryls
starting from arylhydrazines/aromatic solvents and arylboronic acids/aromatic
solvents in the presence of Mn(OAc)3. No isomerization of the formed radical was
observed. Both the aryl coupling reactions, starting from arylhydrazines and
arylboronic acids with benzene as a solvent, were carried out by using the
KMnO4/CH3COOH system. KMnO4/acetic acid and benzene were refluxed under the
Dean–Stark trap until the color of the solution turned brown. Then, arylboronic acid
or arylhydrazine was added to this solution and reflux was continued. The reaction
was controlled with TLC and the corresponding aryl coupling products were
obtained in high yields with the same regioselectivity without isomerization.
55
X KMnO4, CH 3COOH
Benzene
R Reflux R
X = NHNH 2HCl
X = B(OH) 2
NHNH2HCl
95 75125
128
129
NHNH2HCl
NO2
O2N 95 93125
130
131
NHNH 2HCl
95 7547
OCH3
132 OMe
133
NHNH2HCl
90 8347
H3CO
MeO
134 135
56
Table 6 cont’d
NHNH2HCl
90 7347
Br
136 Br
137
NHNH2HCl
F 85 92126
138
F
139
NHNH2HCl
90 7347
Br
136 Br
137
OH 129 96 75125
B
OH
79
OH
B
OH
139 86 92127
F
140
OMe OH OMe
B 90 89128
OH
OMe
OMe
141 142
OH
B
OH
133 90 89128
OMe
143
57
Table 7 cont’d
OH
B
OH
90 95129
Br
Br
144 145
OH
B
OH
137 90 90130
Br
146
OH
B
OH
88 92131
Br
Br
147 148
OH
B
OH
95 -
F3CO
F3CO
149 150
OH
B
OH
89 98132
CF3 CF3
151 152
OH
B
OH 87 94126
153
154
After all the reactions concluded, we found that the KMnO4/CH3COOH system
behaves as Mn(OAc)3. Refluxing of KMnO4/ CH3COOH in organic solvent under
the Dean–stark trap furnishes Mn(OAc)3. In the case of the use of carboxylic acids
other than acetic acid, the corresponding Mn(III) acyloxy derivative should be
formed in order to obtain acyloxy ketones after the oxidation reaction. For the close
inspection of the species for oxidation, after the reflux of the KMnO4/RCOOH in
benzene, the brown mixture was evaporated to dryness and cyclic voltammetric
58
studies were then carried out and compared with the commercially available Mn(III)
acetate.
As a result, both reacted the same in cyclic voltammetry. The formation of Mn(III)
species can be explained via the following equation:
Heiba and Dessau have reported in 1974 that β-keto esters and related dicarbonyl
compounds are oxidized to radicals at 25-70°C in acetic acid24. The application of
Mn(III) to oxidative free-radical cyclizations was investigated initially by Corey,
Fristad, and Snider. Corey and Kang have reported the oxidative cyclization of
59
unsaturated β-keto acids in 198440. In 1985, Snider41 has described the oxidative
cyclization of unsaturated β-keto esters42 and Fristad has surveyed the cyclization of
unsaturated malonic and cyanoacetic acids43.
KMnO 4 OEt
O O O O O
AcOH
OEt OEt
H H 50o C H
O
156
KMnO4
155 AcOH
O OEt
cyclization O
OEt
-H
O O
157
In the view of this result, same reaction is applied to other olefins and β-keto ester
derivatives. Corresponding dihydrofurane derivatives are obtained with moderate to
good yields (Table 8).
OEt OEt 66
155 156 O
157
O O O
O 67
160
161
O O O
O 70
162
163
O
OEt
Ph 160 70
164 O
Ph
165
61
Table 8 cont’d
O
OEt
164 162 73
O
Ph
166
O
OEt
164 158 68
O
Ph
168
OEt
O
O
156 65
167 169
It has long been known that molecules undergo excitation with electromagnetic
radiation. This effect is utilized in household microwave ovens to heat up food.
However, chemists have only been using microwaves as a reaction methodology for
a few years. Some of the first examples gave amazing results, which led to a flood of
interest in this novel technique.
2.3.1. Microwave assisted oxidation and aryl coupling reactions with Mn(OAc)3
and KMnO4 / carboxylic acid/ organic solvent system
First, Mn(OAc)3 reactions are performed by under microwave radiation. Silica gel
and zeolite are tried as supporting surface. Beter results are obtained with zeolite. In
order to distribute all of the substrates (which are solid in most cases) to the reaction
medium several solvents such as benzene, acetonitrile, THF and cyclohexane are
tried and benzene mixed with acetic acid is selected as the solvent to be used (Figure
2.9).
The reaction is also performed under different microwave conditions such as 200,
400, 600 and 800 watt and 800 watt was the best for conversions. Only drawback of
this reaction is the hydrolysis of the acetoxy products to hydroxy derivatives in some
cases.
63
B(OH)2 Mn(OAc)3
benzene/AcOH
zeolite
R
MW R
(800 watt)
O Mn(OAc)3 O
R benzene/AcOH R OH
zeolite
(n) MW (n)
R' (800 watt) R'
Figure 2.9. Synthesis of biaryls and enone oxidation reactions with Mn(OAc)3 under
MW radiation
64
B(OH)2 KMnO4/AcOH/
benzene
zeolite
R
MW R
(800 watt)
O KMnO4/AcOH/ O
R benzene R OH
zeolite
(n) MW (n)
R' (800 watt) R'
Yield %
Product Mn(OAc)3 KMnO4/AcOH/
Benzene
System
O
OAc 50 52
94
O
OAc 54 51
MeO
90
O
Me OAc
61 58
Me
92
O
Me OAc 72 74
O
98
65
Table 9 cont’d
O
F OAc 65 62
O
106
O
OAc (40%)- acetoxy
(40%)- hydroxy Not tried
O
Me
96
O
60 62
OAc
88
O
AcO (50%)- hydroxy (50%)- hydroxy
(50%)- acetoxy (50%)- acetoxy
OMe
108
The α-acetoxy products are obtained with similar yields in both Mn(OAc)3 and
KMnO4/AcOH system. In reactions of 96 and 108, α-hydroxy products are also
obtained with α-acetoxy products which may result from the hydrolysis of the
acetoxylated products. Among these two reactions, KMnO4/AcOH system gives
higher yields and more easy work-up procedures which makes it more preferable.
66
Table 10. Aryl coupling reactions with Mn(OAc)3 and KMnO4/AcOH/benzene
system under MW radiation.
Yield %
Product Mn(OAc)3 KMnO4/AcOH/
Benzene system
F
85 90
F
170
S
F
92 95
F
171
78 84
F3CO
150
S
82 88
F3 CO
172
84 87
Br
148
87 93
CH3
173
S
91 95
CH3
174
67
Table 10 cont’d
76 75
OCH 3
133
92 98
OCH 3
174
S
62 65
MeO
H O
176
68
also occur, giving a mixture of products. Thus, a search for milder and selective
nitrating agents is a good research goal.
Recently Demir et. al. has reported that the reaction of AgNO2 with TMSCl
furnished first N2O3 and hexamethylsiloxane. The reaction of AgNO2/TMSCl with
olefins affords nitrosonitrate, which are converted into α-nitroximes in good yield.
Both nitrosonitrate and nitroximes are converted with acids into furoxane in high
yield. The nitroso nitrates are obtained by addition of N2O3 to the olefines117.
Using silver nitrite and chlorotrimethylsilane is a convenient and mild method for
the nitration of arylboronic acids. This method furnishes the nitrated product in high
yield (76-98% purity for the crude product itself) and is found to be selective and
only ipso-nitration products are obtained. The reaction is easy to perform, and work-
up avoids further purification in many cases. The effect of different solvents on the
reaction system has also been investigated. Tetrahydrofurane (THF) was found to be
the most suitable solvent. In other solvents such as 1,2-dichloroethane, the amount of
chlorination increases.
B(OH)2 NO 2
AgNO2/TMSCl
THF, -20oC
R R
42 77
In an initial reaction AgNO2 and TMSCl was reacted in THF or in acetonitrile at –20
o
C under argon and first white precipitate was formed. The mixture gave some
gaseous products when the reaction temperature arises to room temperature. To the
mixture of AgNO2 and TMSCl at –20 oC was given phenylboronic acid 79 and the
resulted mixture was stirred at this temperature for 3h under argon. After work up
69
only the product isolated was nitrobenzene (93% yield). Low yield formation was
observed by using KNO2 and NaNO2 under similar conditions (25-36%). As shown
in Table 11, representative arylboronic acids are converted into nitro derivatives in
excellent yields. Monitoring of the reactions by GC-MS and analysis of the crude
products by using NMR, IR spectroscopy showed that nitration of arylboronic acids
with AgNO2 and TMSCl takes place at the ipso-position of the aryl ring without ring
nitration or sequential nitration. Also, the reaction proceeds independent of the nature
and position of the substituents. Both arylboronic acids with e-withdrawing and e-
releasing substituents gives corresponding nitro derivative in good yields.
F3 C 95
77d
NO2
O2 N 100
77e
NO2
CH 3 100
77f
70
Table 11 cont’d
NO2
MeO 95
O H
77g
For finding evidence for the possible formation of N2O3 and addition to double bond
the TMSCl and silver nitrite are suspended in deuterated DMF at –5oC. The 1H NMR
spectrum showed the formation of hexamethyldisiloxane. With this result we suggest
that the reaction of AgNO2 with TMSCl leads the formation of N2O3 and
hexamethyldisiloxane. The formation and subsequent addition of N2O3 to alkene
furnished nitroso nitrate as dimer. Heating of dimeric nitroso nitrate affords
furoxan via formation of α-nitro oxime followed by elimination of water.
With aliphatic boronic acids, we were unable to obtain any nitrated product. This
shows that the aromatic ring plays an important electronic role in the ipso-nitration.
By the nitration reaction carried out with AgNO2/TMSCl the interaction between the
boronic acid group and the intermediate active nitrating agent N2O3 species through
boron and the hexamethyldisiloxane due to the high oxophilicity of boron. This helps
the nitration to occur at the ipso position.
71
CHAPTER 3
EXPERIMENTAL
In this study all compounds were identified by using Nuclear Magnetic Resonance
Spectometer (NMR) (Bruker DPX 400 MHz) by using tetramethylsilane (TMS) as an
internal Standard and deutereo chloroform as solvent. Chemical shifts were reported
in ppm relative to CHCl3 (1H: d = 7.26) and CDCl3 (13C: d = 77.0) as an internal
standard; coupling constants are reported in Hz.
Flash column chromatography was done for purifying the products by using Merck
Silica Gel 60 (partical size 40-63 µm). TLC was carried out on aluminum sheets
precoated with silica gel 60F254 (Merck), and the spots were visualized with UV
light (l = 254 nm). MS: ThermoQuest Finnigan multi Mass (EI, 70 eV). Melting
points were measured on a capillary tube apparatus and are uncorrected. The
microwave reactions were carried out in Milestone-Start microwave instrument.
72
3.2 Synthesis of acyloxy enones and biaryls via KMnO4/ carboxylic acid/ organic
solvent system
O
O O
Yield 222 mg, 96%, yellow solid (mp 101–103 oC). IR (CHCl3) νmax: 763, 1608,
1693, 3447 cm-1. 1H NMR (400 MHz, CDCl3) δ 2.09–2.20 (1H, m, CH), 2.15 (3H, s,
CH3), 2.21 (3H, s, CH3), 2.27 (3H, s, CH3), 2.20–2.45 (1H, m, CH2), 2.80–3.00 (m,
2H, CH2), 5.39 (1H, dd, J=5.0, 13.7 Hz, CH), 7.09 (1H, s, CH), 7.60 (1H, s, CH);
13
C NMR (100 MHz, CDCl3) δ 192.9, 169.9, 138.2, 136.3, 136.2, 135.9, 131.7,
125.8, 74.2, 28.4, 25.0, 20.9, 19.3. Anal. Calcd for C14H16O3 (232.28): C, 72.39; H,
6.94. Found: C, 72.61; H, 6.64.
73
3,4-Dihydro-6-methyl-4-oxo-2H-chromen-3-yl acetate (98)
O
O O
Yield 182 mg, 83%, yellow oil. IR (neat) νmax: 762, 1060, 1609, 1693, 3443 cm-1. 1H
NMR (400 MHz, CDCl3) δ 2.12 (3H, s, CH3), 2.25 (3H, s, COCH3), 4.27 (1H, t,
J=11.3 Hz, CH2), 4.43 (1H, dd, J1=5.4 Hz, J2=11.0 Hz, CH2), 5.52 (1H, dd, J1=5.4
Hz, J2=11.4 Hz, CH), 6.79 (1H, d, J=8.5 Hz, CH), 7.24 (1H, d, J=11.7 Hz, CH),
7.58 (1H, s, CH); 13C NMR (100 MHz, CDCl3) δ 20.4, 20.5, 68.3, 69.4, 117.5, 119.6,
127.2, 131.3, 137.2, 159.4, 169.0, 187.5. Anal. Calcd for C12H12O4 (220.22): C,
65.45; H, 5.49. Found: C, 65.34; H, 5.67.
O
F O O
Yield 166 mg, 74%, yellow semisolid. IR (CHCl3) νmax: 762, 845, 1254,1612,1701,
3443 cm-1. 1H NMR (400 MHz, CDCl3) δ 2.15 (3H, s, CH3), 4.32 (1H, dd, J1=5.4
Hz, J2=11.3 Hz, CH2), 4.48 (1H, dd, J1=5.5 Hz, J2=11.1 Hz, CH2), 5.56 (1H, dd,
J1=5.5 Hz, J2=11.4 Hz, CH), 6.91 (1H, dd, J1=4.1 Hz, J2=9.1 Hz, CH), 7.17–7.23
(1H, m, CH3), 7.47 (1H, dd, J1=5.5 Hz, J2=11.1 Hz, CH, CH); 13C NMR (100 MHz,
CDCl3) δ 20.8, 68.9, 69.6, 113.0 (d, 2JCF=23.4 Hz), 119.8 (d, 3JCF=7.2 Hz), 120.8 (d,
3
JCF=6.6 Hz), 124.2 (d, 2JCF=24.6 Hz), 157.8, 158.0 (d, 3JCF=241.9 Hz), 169.3,
187.1. Anal. Calcd for C11H9FO4 (224.19): C, 58.93; H, 4.05. Found: C, 59.14; H,
4.27.
74
1,2,3,4-Tetrahydro-1-oxonaphthalen-2-yl propionate (117)
O
O O
Yield 190 mg, 87%, brown viscous oil. IR (CHCl3) νmax: 762, 1060, 1615, 1710 cm-1 .
1
H NMR (400 MHz, CDCl3) δ 1.17 (3H, t, J=7.5 Hz, CH3), 2.22 (1H, ddd, J1=4.7
Hz, J2=12.7 Hz, J3=25.6 Hz, CH3), 2.29– 2.53 (3H, m, CH2, CH2), 2.93–3.22 (2H,
m, CH2), 5.45 (1H, dd, J1=5.2 Hz, J2=13.2 Hz, CH), 7.18 (1H, t, J=4.8 Hz, CH),
7.25 (1H, t, J=7.5 Hz, CH), 7.41 (1H, t, J=7.0 Hz, CH), 7.95 (1H, d, J=7.8 Hz, CH);
13
C NMR (100 MHz, CDCl3) δ 8.8, 9.2, 27.4, 28.0, 29.2, 74.2, 126.9, 127.9,128.5,
131.5,133.7,142.9,173.3,192.4. Anal. Calcd for C13H14O3 (218.25): C, 71.54; H,
6.47. Found: C, 71.31; H, 6.29.
O
O O
Yield 184 mg, 82%, yellow oil. IR (neat) νmax: 1609, 1665, 1713, 3010 cm-1. 1H
NMR (400 MHz, CDCl3) δ 0.91–0.97 (9H, m, CH3), 1.02 (3H, s, CH3), 1.66 (2H,
sextet, J=7.3 Hz, CH2CH3), 1.88 (3H, s, CH3), 2.07–2.12 (1H, m, CH), 2.30–2.50
13
(3H, m, CH2, CH2), 5.12 (1H, s, CH), 5.81 (1H, s, CH); C NMR (100 MHz,
CDCl3) δ 13.7, 18.5, 20.0, 24.2, 27.3, 36.0, 37.6, 46.1, 80.0, 124.9, 158.0, 172.5,
192.4. Anal. Calcd for C13H20O3 (224.3): C, 69.61; H, 8.99. Found: C, 69.42; H,
8.77.
75
1,2,3,4-Tetrahydro-1-oxonaphthalen-2-yl formate (121)
O
O O
Yield 165 mg, 85%, yellow oil. IR (neat) νmax: 740, 1612, 1690, 2933, 3435 cm-1. 1H
NMR (400 MHz, CDCl3) δ 2.26 (1H, ddd, J1=4.8 Hz, J2=12.8 Hz, J3=17.5 Hz,
CH2), 2.34–2.39 (1H, m, CH2), 3.03 (1H, dt, J1=4.5 Hz, J2=17.0 Hz, CH2), 3.12–
3.20 (1H, m, CH2), 5.54 (1H, dd, J1=5.1 Hz, J2=13.3 Hz, CH), 7.18 (1H, d, J=8.0
Hz, CH), 7.27 (1H, t, J=7.7 Hz, CH), 7.43 (1H, t, J=7.5 Hz, CH), 7.96 (1H, d, J=7.9
Hz, CH), 8.16 (1H, s, CHO); 13C NMR (100 MHz, CDCl3) δ 27.9, 29.1, 73.9, 127.0,
128.1, 128.5, 131.5, 133.9, 42.7, 159.4, 191.3. Anal. Calcd for C11H10O3 (190.2): C,
69.46; H, 5.30. Found: C, 69.33; H, 5.48.
O
O O
Yield 164 mg, 75%, brown oil. IR (neat) νmax: 762, 1609, 1693, 2927, 3443 cm-1. 1H
NMR (400 MHz, CDCl3) δ 2.14–2.24 (1H, m, CH2), 2.21 (3H, s, CH3), 2.27 (3H, s,
CH3), 2.35–2.40 (1H, m, CH2), 2.82–2.90 (1H, m, CH2), 2.95–3.02 (1H, m), 5.51
(1H, dd, J1=5.0 Hz, J2=13.6 Hz, CH), 7.12 (1H, s, CH), 7.62 (1H, s, CH), 8.16 (1H,
13
s, CHO); C NMR (100 MHz, CDCl3) δ 18.7, 20.3, 24.3, 27.8, 73.2, 125.5, 131.1,
135.5, 135.8, 137.5, 159.0, 191.3. Anal. Calcd for C13H14O3 (218.25): C, 71.54; H,
6.47. Found: C, 71.68; H, 6.55.
76
1,2,3,4-Tetrahydro-6-methoxy-1-oxonaphthalen-2-yl formate (123)
O
O O
H
O
Yield 167 mg, 76%, yellow oil. IR (neat) νmax: 1250, 1615, 1703, 2930, 3430 cm-1.
1
H NMR (400 MHz, CDCl3) δ 2.23 (1H, ddd, J1=4.6 Hz, J2=12.6 Hz, J3=17.3 Hz,
CH2), 2.31–2.37 (1H, m, CH2), 2.99 (1H, dt, J1=3.6 Hz, J2=16.9 Hz, CH2), 3.07 -
3.15 (1H, m, CH2), 3.79 (3H, s, OCH3), 5.50 (1H, dd, J1=5.4 Hz, J2=12.9 Hz, CH),
6.56 (1H, s, CH), 6.77 (1H, dd, J1=2.1 Hz, J2=8.8 Hz, CH), 7.93 (1H, d, J=8.8 Hz,
13
CH), 8.16 (1H, s, CHO); C NMR (100 MHz, CDCl3) δ 28.1, 29.1, 55.3, 73.6,
112.5, 113.6, 125.0, 130.5, 145.2, 159.6, 164.0, 190.0. Anal. Calcd for C12H14O4
(220.22): C, 65.45; H, 5.49. Found: C, 65.66; H, 5.27.
O
O O
F H
Yield 135 mg, 61%, colorless oil. IR (neat) νmax: 762, 1605, 1692, 2926, 3440 cm-1.
1
H NMR (400 MHz, CDCl3) δ 1.73–1.84 (1H, m, CH2), 2.00–2.23 (3H, m, CH2,
CH2), 2.92–2.95 (1H, m, CH2), 5.44 (1H, dd, J1=6.9 Hz, J2=12.6 Hz, CH), 7.04 (1H,
td, J1=2.7 Hz, J2=10.7 Hz, CH), 7.11–7.16 (1H, m, CH), 7.38 (1H, dd, J1=2.8 Hz,
13
J2=8.9 Hz, CH), 8.02 (1H, s, CHO); C NMR (CDCl3) δ 23.1, 28.6, 33.0, 76.9,
96.3,116.2 (d, J=27.8 Hz, CF), 119.3 (d, J=21.3 Hz, CF), 132.1 (d, J=7.2 Hz, CF),
137.5 (d, J=3.4 Hz, CF), 138.3 (d, J=6.4 Hz, CF), 159.8, 160.3, 163.6, 197.2. Anal.
Calcd for C12H11FO3 (222.21): C, 64.86; H, 4.99. Found: C, 64.73; H, 4.81.
77
1,2,3,4-Tetrahydro-5-methoxy-1-oxonaphthalen-2-yl formate (126)
O
O O
Yield 154 mg, 70%, brown oil. IR (neat) νmax: 762, 1264, 1609, 1693, 2927, 3443
cm-1. 1H NMR (400 MHz, CDCl3) δ 2.18 (1H, ddd, J1=5.0 Hz, J2=12.8 Hz, J3=17.8
Hz, CH2), 2.34–2.40 (1H, m, CH2), 2.74–2.83 (1H, m, CH2), 3.20 (1H, ddd, J1=2.7
Hz, J2=4.6 Hz, J3=18.0 Hz, CH2), 3.81 (3H, s, CH3), 5.53 (1H, dd, J1=5.0 Hz,
J2=13.6 Hz, CH), 6.95 (1H, d, J=8.0 Hz, CH), 7.22 (1H, t, J=8.0 Hz, CH), 7.55 (1H,
13
d, J=7.9 Hz, CH), 8.17 (1H, s, CHO); C NMR (100 MHz, CDCl3) δ 21.7, 28.2,
55.5, 114.5, 119.5, 127.6, 131.8, 132.6, 156.6, 159.5, 191.6. Anal. Calcd for
C12H12O4 (220.22): C, 65.45; H, 5.49. Found: C, 65.54; H, 5.71.
78
4-(Trifluoromethoxy)-1,10-biphenyl (142)
F3 CO
Yield 226 mg, 95%, white solid (mp 56–58 _C). IR (CHCl3) νmax: 762, 832, 1245,
1625 cm-1. 1H NMR (400 MHz, CDCl3) δ 7.17 (2H, d, J=8.7 Hz, CH), 7.26 (1H, t,
J=7.4 Hz, CH), 7.34 (2H, d, J=7.4 Hz, CH, CH), 7.44 (2H, t, J=7.4 Hz, CH, CH),
7.49 (2H, t, J=8.6 Hz, CH, CH); 13C NMR (100 MHz CDCl3) δ 121.2, 127.1, 127.6,
128.4, 128.8, 139.9, 140.1, 148.7. Anal. Calcd for C13H9F3 (238.21): C, 65.55; H,
3.81. Found: C, 65.34; H, 3.77.
3.3. Synthesis of acyloxy enones and biaryls via Mn(OAc)3, KMnO4/ acetic acid
system under microwave radiation
3.3.1 General procedure for α-acyloxylation of enones and biaryl synthesis via
Mn(OAc)3 under microwave radiation
3.3.2 General procedure for a-acyloxylation of enones and biaryl synthesis via
KMnO4/ acetic acid system under microwave radiation
79
0.3 mmol of KMnO4 and 500 mg of zeolite in 5 mL benzene–AcOH (20:1) or
thiophene- AcOH was stirred under 800 watt microwave radiation until the color of
the solution turns into brown.To this solution 0.1 mmol of aryl boronic acid or enone
was added and stirred under 800 watt microwave radiation (30 min.-1 hour). The
reaction is monitored by TLC. After all the starting material is consumed, the
reaciton mixture was diluted with ether and neutralized with NaHCO3. The resulting
organic phase was dried over MgSO4 and concentrated under vacuum. If necessary,
the crude products were purified by column chromatography using EtOAc–hexane as
an eluent.
2-(3,5-difluorophenyl)thiophene (171)
S
F
Brown oil; 1H NMR (400 MHz, CDCl3) δ 6.57-6.63 (1H, m, CH), 6-95-7.02 (3H, m,
CH), 7.20 (2H, d, J=5.2 Hz, CH); 13C-NMR ( 100MHz, CDCl3) δ 102.5 (t, JCF=24.7
Hz), 108.8 (dd, JCF1=7.5, JCF2=18.5 Hz), 121.7, 124.4, 126.0, 126.7, 128.1, 137.5 (t,
JCF=9.9 Hz), 141.9, 163.4 (dd, JCF1=247, JCF2=12.6 Hz).
F3 CO
80
Brown solid, mp= 72.5-75.3 oC; 1
H NMR (400 MHz, CDCl3) δ 6.98 (1H, t, J=4.2
Hz, CH), 7.13-7.32 (4H, m, CH), 7.52 (2H, d, J=8.6); 13C-NMR (100MHz, CDCl3) δ
121.3, 121.4, 123.6, 125.3, 126.1, 127.2, 127.7, 128.0, 133.3, 142.8, 148.5.
MeO
H O
Green oil; 1H NMR (400 MHz, CDCl3) δ 3.89 (3H, s, CH3), 6.90-6.98 (2H, m, CH),
7.15-7.19 (2H, m, CH), 7.67 (1H, dd, J1= 2.5, J2= 8.7 Hz, CH), 7.96 (1H, d, J=2.5
13
Hz, CH), 10.39 (1H, s, CH); C-NMR ( 100MHz, CDCl3) δ 54.4, 110.9, 121.8,
123.5, 123.9, 124.6, 126.6, 126.9, 131.9, 141.7, 159.9, 187.6.
3.4 Synthesis of dihydrofurans from alkenes and 1,3 dicarbonyl copounds via
KMnO4/acetic acid/organic solvent system
81
Ethyl 2-phenyl-4,8b-dihydro-3aH-indeno[1,2-b]furan-3-carboxylate (163)
OEt
Yellow oil. 1H-NMR(CDCl3) δ 1.20 (3H, t, J=7.0), 3.24 (1H, d, J=17.2), 3.42 (1H,
dd, J1=8.4, J2= 17.2), 4.08-4.21 (2H, m), 4.28 (1H, dt, J1=2.6, J2= 9.0), 6.10 (1H, d,
13
J=9.3), 7.22-7.35 (6H, m), 7.49 (1H, d, J=7.3 Hz), 7.64 (2H, d, J=7.7 Hz); C-
NMR(CDCl3) δ 14.6, 19.5, 19.7, 26.8, 39.0, 45.3, 59.1, 89.3, 104.0, 124.5, 125.3,
125.7, 126.9, 129.3, 133.9, 140.5, 142.8, 165.6, 175.4.
OEt
Colorless oil. 1H-NMR(CDCl3) δ 1.27 (3H, t, J=7.1 Hz), 2.13 (3H, s), 3.13 (1H, d,
J=17.1 Hz), 3.30 (1H, dd, J1=6.2, J2= 14.5 Hz), 4.03 (1H, t, J=8.5 Hz), 4.12-4.24
(2H, m), 5.95 (1H, d, J=9.2 Hz), 7.17-7.28 (3H, m), 7.41 (1H, d, J=7.8 Hz); 13C-
NMR(CDCl3) δ 14.4, 14.6, 39.1, 45.2, 59.2, 89.7, 106.3, 125.3, 125.7, 126.9, 129.4,
140.3, 143.1, 165.8, 167.5.
OEt
82
Yellow oil. 1H-NMR(CDCl3) δ 0.98 (3H, t, J=7.6 Hz), 1.22 (3H, t, J=7.1 Hz), 2.45
(1H, m), 2.60 (1H, m), 3.05 (1H, dd, J1=1.7, J2= 17.1 Hz), 3.23 (1H, dd, J1=8.3, J2=
17.1 Hz), 3.96 (1H, t, J=8.3 Hz), 4.11 (2H, m), 5.88 (1H, d, J=9.1 Hz), 7.16 (3H, m),
7.34 (1H, d, J=4.4 Hz); 13C-NMR(CDCl3) δ 11.1, 14.6, 21.5, 39.1, 45.3, 59.1, 89.5,
105.1, 125.3, 125.7, 126.9, 129.4, 140.4, 142.9, 165.5, 172.2.
O
OEt
Yellow oil. 1H-NMR(CDCl3) δ 0.94 (2H, d, J=6.9 Hz), 1.13 (2H, d, J=6.9 Hz), 1.30
(3H, t, J=7.1 Hz), 3.12 (1H, dd, J1=1.6, J2= 17.0 Hz), 3.30 (1H, dd, J1=8.2, J2= 17.1
Hz), 3.54 (1H, septet, J=6.9 Hz), 4.02 (1H, dt, J1=2.4, J2= 8.8 Hz), 4.18 (2H, m),
5.95 (1H, d, J=9.1 Hz), 7.26 (3H, m), 7.42 (1H, d, J=7.4 Hz); 13C-NMR(CDCl3) δ
14.6, 19.5, 19.7, 26.8, 39.0, 45.3, 59.1, 89.3, 104.0, 125.2, 125.6, 126.9, 129.3, 140.4,
142.8, 165.5, 175.3.
Ethyl 2-isopropyl-7a-phenyl-3a,4,5,6,7,7a-hexahydrobenzofuran-3-carboxylate
(165)
O
OEt
O
Ph
Yellow oil. 1H-NMR(CDCl3) δ 1.14-1.18 (6H, m), 1.34-1.65 (5H, m), 1.76-1.93 (3H,
m), 3.27 (1H, t, J=5.3 Hz), 3.62 (1H, septet, J=6.9 Hz), 3.96-4.11 (2H, m), 7.15-7.18
13
(1H, m), 7.25 (2H, t, J=7.6 Hz), 7.32 (2H, t, J=7.2 Hz); C-NMR(CDCl3) δ 14.5,
83
17.8, 18.4, 19.6, 19.9, 25.6, 27.1, 34.0, 46.9, 59.0, 89.4, 104.2, 124.1, 127.1, 128.7,
147.7, 165.5, 174.8.
O
OEt
O
Ph
Yellow oil. 1H-NMR(CDCl3) δ 1.08 (3H, t, J=7.1 Hz), 1.36-1.46 (1H, m), 1.55-1.69
(3H, m), 1.78-1.86 (1H, m), 2.06-2.12 (2H, m), 3.41 (1H, t, J=6.1 Hz), 3.93-4.03
(2H, m), 7.15 (1H, t, J=7.2 Hz), 7.24 (2H, t, J=7.6 Hz), 7.28-7.34 (3H, m), 7.38 (2H,
13
d, J=7.6 Hz), 7.76-7.78 (2H, m) ; C-NMR(CDCl3) δ 13.1, 18.3, 18.6, 26.2, 26.3,
33.7, 47.0, 58.3, 88.4, 107.3, 123.3, 124.3, 126.0, 126.5, 127.1, 128.3, 129.0, 129.5,
146.0, 163.1, 163.8.
Ethyl-2-methyl-7a-phenyl-3a,4,5,6,7,7a-hexahydrobenzofuran-3-carboxylate
(168)
O
OEt
O
Ph
Yellow oil. 1H-NMR(CDCl3) δ 1.13 (3H, t, J=7.1 Hz), 1.29-1.37 (1H, m), 1.45-1.59
(4H, m), 1.73-1.81 (1H, m), 1.90-1.96 (2H, m), 2.21 (3H, s), 3.20 (1H, t, J=5.6 Hz),
3.93-4.08 (2H, m), 7.11-7.15 (1H, m), 7.22 (2H, t, J=7.3 Hz), 7.27-7.31 (2H, m);
13
C-NMR(CDCl3) δ 14.4, 14.5, 18.8, 19.2, 26.4, 34.3, 46.9, 59.2, 90.2, 107.5, 124.3,
127.1, 128.2, 147.4, 166.1, 167.3.
84
Ethyl 2,5-dimethyl-5-phenyl-4,5-dihydrofuran-3-carboxylate(169)
OEt
O
Yellow oil. 1H-NMR(CDCl3) δ 1.20 (3H, t, J=7.2 Hz), 1.60 (3H, s), 2.22 (3H, s),
3.00 (2H, dd, J1=14.4 Hz, J2=34.8 Hz), 4.07 (2H, q, J=7.2 Hz), 7.14-7.18 (1H,m),
7.23-7.28 (4H, m)
To a solution of 0.1 mmol of AgNO2 and 0.1 mmol TMSCl in THF at -20oC was
added 0.1 mmol of arylboronic acid under argon atmosphere. Reaction mixture is
stirred for 3 hours at -20oC. The solution is filtered and diluted with DCM and
washed with NaCl solution. The resulting organic phase was dried over MgSO4 and
concentrated under vacuum. If necessary, the crude products were purified by
column chromatography using EtOAc–hexane as an eluent. In most cases, the direct
filtering of the reaction mixture through a pad of silica provided pure products.
85
CHAPTER 4
CONCLUSION
In summary, in the first part of this thesis, the oxidation reactions of enones and
aromatic ketones were carried out with potassium permanganate/carboxylic acid in
an organic solvent and acyloxy enones were obtained in high yields. The potassium
permanganate/carboxylic acid system in an organic solvent was applied to
dihydrofuran synthesis and aryl coupling reactions with arylboronic acids and
arylhydrazines, in which biaryl products were obtained in high yields. This method
enables one to obtain Mn(III) acyloxy derivatives in situ. The reactions are simple,
selective, and cheap compared to other methods. The results showed that the
potassium permanganate/carboxylic acid system is a powerful substitute for
manganese(III) acetate.
X
KMnO4, AcOH
Benzene
R
Reflux R
X = NHNH2HCl
X = B(OH)2
O O
R KMnO4, AcOH R OAc
(n) Benzene (n)
R' Reflux R'
O
O O OR2
R5 R3 R3
KMnO4, AcOH
+ R1 R4
OR2 R1
R6 R4 Benzene
Reflux R5 O
R6
B(OH)2 NO2
AgNO2 /TMSCl
THF, -20 oC
R R
42 77
87
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97
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98
APPENDIX A
NMR DATA
99
Figure 4.4 1H-NMR spectrum of 1,2,3,4-Tetrahydro-5,7-dimethyl-1-oxonaphthalen-
2-yl acetate (92)
101
Figure 4.8 1H-NMR spectrum of 1,2,3,4-Tetrahydro-1-oxonaphthalen-2-yl
propionate (117)
102
Figure 4.10 1H-NMR spectrum of 4,6,6-Trimethyl-2-oxocyclohex-3-enyl butyrate
(119)
103
Figure 4.12 1H-NMR spectrum of 1,2,3,4-Tetrahydro-1-oxonaphthalen-2-yl formate
(121)
104
Figure 4.14 1H-NMR spectrum of 1,2,3,4-Tetrahydro-5,7-dimethyl-1-
oxonaphthalen-2-yl formate (122)
105
Figure 4.16 1H-NMR spectrum of 1,2,3,4-Tetrahydro-6-methoxy-1-oxonaphthalen-
2-yl formate (123)
106
Figure 4.18 1H-NMR spectrum of 2-Fluoro-6,7,8,9-tetrahydro-9-oxo-5H-
benzo[7]annulen-8-yl formate (125)
107
Figure 4.19 1H-NMR spectrum of 1,2,3,4-Tetrahydro-5-methoxy-1-oxonaphthalen-
2-yl formate (126)
108
Figure 4.21 1H-NMR spectrum of 4-(Trifluoromethoxy)-1,10-biphenyl (142)
109
Figure 4.23 1H-NMR spectrum of Ethyl 2-methyl-4,8b-dihydro-3aH-indeno[1,2-
b]furan-3-carboxylate (157)
110
Figure 4.25 1H-NMR spectrum of Ethyl 2-ethyl-4,8b-dihydro-3aH-indeno[1,2-
b]furan-3-carboxylate (159)
111
Figure 4.27 1H-NMR spectrum of Ethyl 2-isopropyl-4,8b-dihydro-3aH-indeno[1,2-
b]furan-3-carboxylate (161)
112
Figure 4.29 1H-NMR spectrum of Ethyl 2-phenyl-4,8b-dihydro-3aH-indeno[1,2-
b]furan-3-carboxylate (163)
113
Figure 4.31 1H-NMR spectrum of ethyl 2-isopropyl-3a-phenyl-3a,4,5,6,7,7a-
hexahydrobenzofuran-3-carboxylate (165)
114
Figure 4.33 1H-NMR spectrum of ethyl 2,3a-diphenyl-3a,4,5,6,7,7a-
hexahydrobenzofuran-3-carboxylate (166)
115
Figure 4.35 1H-NMR spectrum of ethyl 2-methyl-3a-phenyl-3a,4,5,6,7,7a-
hexahydrobenzofuran-3-carboxylate (168)
116
Figure 4.37 1H-NMR spectrum of 3,5-difluorobiphenyl (169)
117
Figure 4.39 1H-NMR spectrum of 2-(3,5-difluorophenyl)thiophene (170)
119
Figure 4.43 1H-NMR spectrum of 2-Methoxy-5-(thiophen-2-yl) benzaldehyde (175)
120
Figure 4.45 1H-NMR spectrum of ethyl 2,5-dimethyl-5-phenyl-4,5-dihydrofuran-3-
carboxylate (169)
121
CURRICULUM VITAE
PERSONAL INFORMATION
Surname, Name: Fındık, Hamide
Nationality: Turkish (TC)
Date and Place of Birth: 21 March 1979 , Çankırı
Marital Status: Single
email: hamisfindik@hotmail.com
EDUCATION
Degree Institution Year of Graduation
PhD METU Chemistry 2009
MS METU Chemistry 2004
BS METU Chemistry Education 2002
FOREIGN LANGUAGES
English
PUBLICATIONS
1. Ayhan S. Demir, Hamide Findik, Elif Köse. A new and efficient
chemoenzymatic route to both enantiomers of α‘-acetoxy-α-methyl and γ-hydroxy-α-
methyl cyclic enones. Tetrahedron: Asymmetry , 2004, 15, 777.
122