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    Covid 3

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    Vinodh Vijayan
    Eight COVID-19 patients in China were successfully treated with mesenchymal stem cells (MSCs), including two critically ill patients. MSCs improved lung function and reduced inflammation and organ damage caused by the SARS-CoV-2 virus. No side effects were observed. The studies confirm the safety and efficacy of MSCs for treating critical COVID-19 cases and respiratory system damage. However, large numbers of MSCs (millions of cells per kg of weight) are required, which necessitates expanding the cells in a cell production facility.

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    Covid 3

    Uploaded by

    Vinodh Vijayan
    17 views4 pages
    Eight COVID-19 patients in China were successfully treated with mesenchymal stem cells (MSCs), including two critically ill patients. MSCs improved lung function and reduced inflammation and organ damage caused by the SARS-CoV-2 virus. No side effects were observed. The studies confirm the safety and efficacy of MSCs for treating critical COVID-19 cases and respiratory system damage. However, large numbers of MSCs (millions of cells per kg of weight) are required, which necessitates expanding the cells in a cell production facility.

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    COVID 3

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    Eight COVID-19 patients in China were successfully treated with mesenchymal stem cells (MSCs), including two critically ill patients. MSCs improved lung function and reduced inflammation and organ damage caused by the SARS-CoV-2 virus. No side effects were observed. The studies confirm the safety and efficacy of MSCs for treating critical COVID-19 cases and respiratory system damage. However, large numbers of MSCs (millions of cells per kg of weight) are required, which necessitates expanding the cells in a cell production facility.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    17 views4 pages

    Covid 3

    Uploaded by

    Vinodh Vijayan
    Eight COVID-19 patients in China were successfully treated with mesenchymal stem cells (MSCs), including two critically ill patients. MSCs improved lung function and reduced inflammation and organ damage caused by the SARS-CoV-2 virus. No side effects were observed. The studies confirm the safety and efficacy of MSCs for treating critical COVID-19 cases and respiratory system damage. However, large numbers of MSCs (millions of cells per kg of weight) are required, which necessitates expanding the cells in a cell production facility.

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    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
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    3/28/2020 Covid-19, mesenchymal stem cells effective against Sars-CoV-2 - Bioscience Institute

    Webcam Social ENG

    DUBAI HEALTHCARE CITY


    About
    RAS AL KHOR us 2^Our Services
    - Ind. Area Latest News Trials Brochures Contacts
    info@bioinst.ae

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    ITALY

    ROMA - Tor Vergata University

    Covid-19, mesenchymal stem


    MILANO - San Raffaele Hospital
    info@bioinst.com

    cells effective against Sars-CoV-2


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     14  Share
    4 March 2020 Stem Cell
    SAN MARINO

    SAN MARINO - Headquarter


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    HONG KONG

    Eight patients were successfully treated in China. Among them, 2 were


    critically ill. The first that defeated Covid-19 with mesenchymal stem cells
    is a 65-year-old woman. Other 7 patients were successfully treated for the
    HK SCIENCE PARK
    new coronavirus (Sars-Cov-2) infection in Beijing.
    MONGKOK - 639 Nathan Road
    TSIM SHA TSUI - 5 Canton Road

    Experimental treatments against the


    info@bioinst.com
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    new coronavirus
    UNITED ARAB EMIRATES

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    https://bioinst.com/en/covid-19-mesenchymal-stem-cells-effective-against-sars-cov-2/ 1/4
    3/28/2020 Covid-19, mesenchymal stem cells effective against Sars-CoV-2 - Bioscience Institute

    Several experimental treatments against the new coronavirus are under clinical evaluation:
    antiviral drugs, steroids, traditional Chinese medicine, serum from healed patients.
    Webcam Social
    Someone
    ENG
    thought stem cells could have been a valuable solution too, and his hypothesis turned out to be
    a viable option.
    TheDUBAI
    newsHEALTHCARE
    comes fromCITY chinaXiv.org, the Chinese open repository for scientific researchers
    maintained and
    RAS AL KHOR -operated
    About us 2^by
    Ind. Area the
    Our research library
    Services Latestservice
    News ofTrials
    the Chinese AcademyContacts
    Brochures of Science.
    Here, a team of experts led by Bing Liang from Baoshan People’s Hospital published the details
    info@bioinst.ae
    of the case of a critically ill 65-year-old Chinese woman infected with Sars-CoV-2, whose
    conditions significantly
    Privacy Policy improved after the infusion of mesenchymal stem cells (MSCs). Not only,
    | Cookie Policy
    as reported once again in chinaXiv.org, 7 Covid-19 pneumonia patients (1 critically severe, 4
    ITALY
    severe and 2 common) were treated with MSCs at Beijing YouAn Hospital, and their functional
    outcomes significantly improved.

    Stem cells and Covid-19


    ROMA - Tor Vergata University
    At least 14 trials using stem cells to treat coronavirus patients were reported in China. Animal
    MILANO - San Raffaele Hospital
    tests suggested stem cells might be able to repair the severe organ damage caused by Sars-
    info@bioinst.com
    CoV-2. Moreover, MSCs have shown very significant immunomodulation. In particular, these
    stem cells can secrete many cytokines (molecules that participate in inflammatory processes)
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    and can directly interact with immune cells. Their immunomodulatory action is further triggered
    SAN MARINO molecules.
    by virus-associated
    The clinical trial conducted in Beijing demonstrated that MSCs are naturally immune to Sars-
    CoV-2. They secrete anti-inflammatory factors that seem to counteract the mechanisms at the
    base of the virus-induced organ damage.

    No side effects
    SAN MARINO - Headquarter
    info@bioinst.com
    Nor Baoshan People’s Hospital infusion nor treatments conducted in Beijing resulted in obvious
    side effects, demonstrating that MSCs are well tolerated. Moreover, both critically ill patients
    Privacy | significantly
    conditions Cookie Policy improved, with reduction in inflammation, improved respiration and
    white bloodKONG
    HONG cells count, reduced pneumonia infiltration, and negative Sars-CoV-2 presence
    tests.

    According to Beijing experts, MSCs would act by improving lung microenvironment, inhibiting
    immune system overactivation, promoting tissue repair, protecting lung alveoli epithelial cells,
    preventing pulmonary fibrosis, and improving lung function.
    HK SCIENCE PARK
    MONGKOK - 639 Nathan Road

    Huge numbers of stem cells


    TSIM SHA TSUI - 5 Canton Road
    info@bioinst.com
    According
    Privacy | to Liang
    Cookie and colleagues, umbilical blood cord-derived MSCs infusion «might be an
    Policy
    ideal choice to be used or combined with other immune modulating agents». However, to

    obtain such results,
    UNITED experts utilized huge numbers of MSCs. The Baoshan patient received
    ARAB EMIRATES Privacy3
    - Terms

    https://bioinst.com/en/covid-19-mesenchymal-stem-cells-effective-against-sars-cov-2/ 2/4
    3/28/2020 Covid-19, mesenchymal stem cells effective against Sars-CoV-2 - Bioscience Institute

    infusions of 50 million umbilical blood cord-derived MSCs, whereas each Beijing patients
    received 1 infusion of 1 million cells per kilogram of weight. Such hugeWebcam
    numbersSocial
    can be ENG
    obtained only in a cell factory able not only to purify and preserve stem cells, but also to
    efficiently expand them.
    DUBAI HEALTHCARE CITY
    As highlighted
    RAS AL KHOR by
    About Giuseppe
    - Ind. Mucci,
    us 2^Our
    Area CEO of Bioscience
    Services Latest NewsInstitute (a leader
    Trials companyContacts
    Brochures in stem cells
    info@bioinst.ae «these studies confirm the efficacy and the safety of mesenchymal stem
    cryopreservation),
    cells in the treatment of critical immunodeficiency associated with high systemic inflammation
    too.Privacy
    Immunomodulatory and antiinflammatory properties of these cells in the treatment of
    Policy | Cookie Policy
    respiratory
    ITALY system degenerative processes were confirmed by 15 completed clinical trials, and
    more than 50 new trials will explore them. Scientific research is highlighting that these cells can
    not be substituted by other drugs in the treatment of respiratory system degenerative process».

    Mesenchymal stem cells are characterized by an enormous advantage. «They can be obtained
    from fat», Mucci explains. «That means that everyone can utilize his/her cells, eliminating any
    ROMA - Tor Vergata University
    contamination or rejection risk. But expanding them to the quantity needed for infusion, that
    MILANO - San Raffaele Hospital
    corresponds to at least 1 million cells per kg of weight, takes 2 to 3 weeks. That is why it is useful
    info@bioinst.com
    to cryopreserve a personal reserve of mesenchymal stem cells, that would allow to access an
    early, more successful, treatment».
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    SAN MARINO
    Bioscience Institute offers the possibility to cryopreserve mesenchymal stem cells. For more
    informations, fill out the online request form or call us at +971 (0)4 375 7220.

    References

    SAN MARINO - Headquarter


    Leng Z et al. Transplantation of ACE2- mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia.
    info@bioinst.com
    chinaXiv:202002.00080v1

    Liang B et al. Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells.

    chinaXiv:202002.00084v1
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    ClinicalTrials.gov. https://bit.ly/38ndxJh
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    3/28/2020 Covid-19, mesenchymal stem cells effective against Sars-CoV-2 - Bioscience Institute

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