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    Monocyte, Immature (Promonocyte, Monoblast)

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    Ilinca
    This document provides information about monoblasts and promonocytes from the Color Atlas of Hematology: 1) Monoblasts are large cells with relatively more cytoplasm than myeloblasts, and have round or oval nuclei with finely dispersed chromatin and distinct nucleoli. 2) Promonocytes have nuclear and cytoplasmic features between monoblasts and mature monocytes, with nuclei that are more irregular and often indented or lobulated compared to monoblasts. 3) Both monoblasts and promonocytes can appear in small numbers in reactive conditions but are seen primarily in malignant conditions affecting the monocytic cell line.

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    Monocyte, Immature (Promonocyte, Monoblast)

    Uploaded by

    Ilinca
    368 views1 page
    This document provides information about monoblasts and promonocytes from the Color Atlas of Hematology: 1) Monoblasts are large cells with relatively more cytoplasm than myeloblasts, and have round or oval nuclei with finely dispersed chromatin and distinct nucleoli. 2) Promonocytes have nuclear and cytoplasmic features between monoblasts and mature monocytes, with nuclei that are more irregular and often indented or lobulated compared to monoblasts. 3) Both monoblasts and promonocytes can appear in small numbers in reactive conditions but are seen primarily in malignant conditions affecting the monocytic cell line.

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    CV1_CT0118

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    This document provides information about monoblasts and promonocytes from the Color Atlas of Hematology: 1) Monoblasts are large cells with relatively more cytoplasm than myeloblasts, and have round or oval nuclei with finely dispersed chromatin and distinct nucleoli. 2) Promonocytes have nuclear and cytoplasmic features between monoblasts and mature monocytes, with nuclei that are more irregular and often indented or lobulated compared to monoblasts. 3) Both monoblasts and promonocytes can appear in small numbers in reactive conditions but are seen primarily in malignant conditions affecting the monocytic cell line.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    368 views1 page

    Monocyte, Immature (Promonocyte, Monoblast)

    Uploaded by

    Ilinca
    This document provides information about monoblasts and promonocytes from the Color Atlas of Hematology: 1) Monoblasts are large cells with relatively more cytoplasm than myeloblasts, and have round or oval nuclei with finely dispersed chromatin and distinct nucleoli. 2) Promonocytes have nuclear and cytoplasmic features between monoblasts and mature monocytes, with nuclei that are more irregular and often indented or lobulated compared to monoblasts. 3) Both monoblasts and promonocytes can appear in small numbers in reactive conditions but are seen primarily in malignant conditions affecting the monocytic cell line.

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    of 1

    6

    CAP TODAY | JANUARY 2018

    Monocyte, Immature (Promonocyte, Monoblast)


    Here’s a look inside the new Color Atlas lated or has delicate folding or creasing of the
    SYNONYMS
    of Hematology: An Illustrated Field Guide nuclear membrane. Nucleoli are present but often Monoblast, promonocyte
    Based on Proficiency Testing, from the sec- not as distinct as in a monoblast. Nuclear chro­
    tion on granulocytic and monocytic cells. matin is more immature and delicate than that of VITAL STATISTICS
    Immature monocytes are usually not seen in any a mature monocyte. The cytoplasm contains Size ������������������������15-25 µm
    N:C ratio ��������������7:1 to 3:1
    significant number except in malignancies in­ uniformly distributed, fine, azurophilic granules Cell shape �����������round to oval
    volving the monocytic cell line. The monoblast with generally few cytoplasmic vacuoles. Nuclear shape ���round or indented
    is a large cell with relatively more cytoplasm than Some monoblasts cannot be distinguished Chromatin ����������reticular, lacy
    Nucleoli ���������������one to two present
    a myeloblast. The monoblast nucleus is round or morphologically from other blast forms, hence
    Cytoplasm ����������gray to cloudy blue, few red granules
    oval and has finely dispersed chromatin with the need for using other means (e.g., cytochem­
    distinct nucleoli. The cytoplasm is blue to gray- istry and flow cytometry) before assigning a KEY DIFFERENTIATING FEATURES
    blue and may contain small, scattered azurophilic particular lineage to a blast cell. For purposes of High N:C ratio, nucleoli, indented nucleus
    granules, but Auer rods are rare. Monoblasts proficiency testing, selection of the response Enzyme cytochemical stain: nonspecific esterase
    positive
    differentiate into promonocytes (see A Closer “monocyte, immature (promonocyte, mono­ Immunophenotype: CD4, HLA-DR, CD13, CD33,
    Look At . . . Life Cycle of Monocytes); promono­ blast)” should be reserved for malignant cells in CD36, CD38, CD64, CD11b, CD45 positive;
    cytes are considered to be monoblast equivalents myeloid neoplasms (see A Closer Look ­variable CD14, CD15
    for classification determination. Promonocytes At . . . Acute Myeloid Leukemia and Related Neo-
    have nuclear and cytoplasmic characteristics that plasms). A spectrum of immature, non-neoplastic OTHER FEATURES
    May appear as undefined “blast cell”
    are between those of monoblasts and mature monocytes may circulate in small numbers in Vacuoles may be seen in cytoplasm
    monocytes. The nucleus is more irregular than reactive conditions, including cells with enlarged
    that of a monoblast and is often indented or lobu­ nuclei and small nucleoli. POTENTIAL LOOK-ALIKES
    Other blasts (myeloblast, lymphoblast, megakaryo-
    Monoblast Promonocyte blast)
    Blastic plasmacytoid dendritic cell neoplasm
    Natural killer cell
    Mature monocyte
    Dysplastic myeloid or erythroid precursors
    nucleoli Atypical lymphocyte (i.e., Epstein-Barr virus infection,
    rarely)
    Lymphoma cell or prolymphocyte
    coarse nuclear chromatin Carcinoma

    ASSOCIATED DISEASE STATES AND CONDITIONS


    Acute monocytic/monoblastic leukemia
    Acute myelomonocytic leukemia
    normal RBC Chronic myelomonocytic leukemia
    gray-blue cytoplasm containing a few red granules Myelodysplastic/myeloproliferative neoplasm

    lacy chromatin and prominent nucleolus


    7 µm

    BCK/BCP-17, 2002 (Blood, WG, X400) EHE1-09, 2013 (Blood, WG, X400) BCK/BCP-14/XHP-20, 2009 (Blood, WG, X360)
    Identification Referee % Participant % Identification Referee % Participant % Identification Referee % Participant %
    Monocyte, immature 80.0 71.1 Monocyte, immature - 47.0 Immature monocyte 66.7 59.7
    Monocyte 10.0 14.8 Neutrophil, promyelocyte - 13.7 Monoblast 28.2 17.5
    A promonocyte is typically large like a monoblast with Neutrophil, myelocyte - 13.1
    The cell indicated by the arrow is an immature mono-
    a moderate amount of cytoplasm. The chromatin con- Nucleated red cell, normal or abn. - 10.7
    cyte. These cells differ from mature monocytes in that
    tains a similar fine pattern; however, the nucleus dem- The arrowed cells are immature monocytes, which in- their chromatin pattern is finer than the clumped pat-
    onstrates a delicate folded or grooved appearance. The clude monoblasts and promonocytes. These cells may tern of a mature monocyte. Also the nucleus lacks the
    nucleolus is faint to indistinct. The cytoplasmic granu- have overlapping morphologic features. The arrowed more prominent indentation of a mature monocyte and
    lation is also apparent. Occasional vacuoles may be cells in this image have round to oval nuclear contours nucleoli are present. There is a high N:C ratio and the
    present, but this is not a typical feature. These cells are with fine, lacy chromatin and distinct nucleoli, best re- cytoplasm is gray–blue. The other nucleated cells in the
    part of a leukemic population and therefore should not sembling monoblasts. Monoblasts are usually large field have similar nuclear and cytoplasmic character-
    be classified as benign monocytes. It can sometimes and may appear as a typical myeloblast or may have istics and are also examples of immature monocytes.
    be difficult to distinguish benign from leukemic mono- increased basophilic cytoplasm and lower N:C ratios,
    cytes in peripheral blood. In this instance, the leukemic as seen in this image.
    monocytes have morphologically distinctive immature
    features. Virtual Peripheral Blood Smear
    http://capatholo.gy/H16_151-09-1

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