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Pharma Q Bank

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Short Notes on General Pharmacology (PK)

Pharmacokinetics
1. Bioavailability

Definition ,Factors affecting bioavailability

2. Volume of Distribution (V)

 Definition ,How different Factors affecting V

3. Clearance (Cl) , Plasma protein Binding

4. Therapeutic Drug Monitoring (TDM), First Pass Metabolism

5. Orders of Kinetics, Steady state plasma concentration

6. Prodrugs, Biotransformation, Cytochrome P450

Pharmacodynamics
1. G-protein Coupled Receptors (GPCR), Drug Antagonism

2. Receptor Antagonism, Synergism

3. Therapeutic Index, Dose-Response Curve (DRC)

4. Therapeutic window ,Tachyphylaxis

Cholinergic System
1. Co-transmitters, Mushroom poisoning

2. Anti-Cholinesterases, Organophosphate Poisoning

3. Cholinesterase Reactivators, Edrophonium Test

4. Belladona Poisoning, Therapeutic uses of Anticholinergic Drugs


Adrenergic Drugs
1. Synthesis of Sympathomimetic Amines, Adrenergic Receptors

2. Vasomotor Reversal Of Dale, Therapeutic Classification of Adrenergic


Drugs, Classification and Therapeutic uses of ß – Blockers

3. Anorectic Agents, Drugs Used in Open Angle Glaucoma

4. Therapeutic Uses of Adrenaline

Short Notes: Rheumatoid Arthritis and Gout


Rheumatoid Arthritis:

 DMARDs (Disease Modifying Anti-Rheumatoid Drugs)

 Biological Response Modifiers (BRMs)

Gout:

 Pharmacotherapy of Acute Gout, Uricosuric Agents

 Xanthine Oxidase inhibitor

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