Volume 19 Issue 11, November 2024

DNA origami tension sensors, created by integrating DNA origami sheets with molecular tension probes, enable the quantification of mechanical forces involved in T cell receptor interactions at intermembrane junctions.

Photobleaching-harnessing charge conversion initiates nanomedicine transcytosis, improving therapeutic outcomes in various rectal tumour mouse models.

This Perspective highlights bottom-up molecular engineering and modular nanobiotechnological approaches for developing effective immunotherapeutics and their potential in personalized medicine.

The authors propose a framework to be followed during preclinical investigation of nanomedicines to increase their translatability potential.

An on-chip nano-bolometer integrated with a Josephson junction quantitatively measures the Josephson radiation up to about 100 GHz frequency. This wide-band, thermal detection scheme of microwave photons provides a sensitive detector of Josephson dynamics beyond the standard conductance measurements.

Electrostatically tunable graphene-based electronic interferometers show non-trivial exchange statistics of quasiparticles, revealing their wave-like properties.

A metasurface is used to generalize the Rashba effect from circular polarizations to any polarization state for thermal emission.

Electrically addressable VO₂ elements show large resonance shifts during phase transitions, producing a brilliant colour change at a modulation rate of 70 kHz.

In situ synchrotron X-ray tools are used to perform microstrain screening during solid-state synthesis of battery materials, leading to fewer structural defects and improved performance.

Here, the authors present a data storage and computation engine comprised of DNA adsorbed to soft dendricolloids, demonstrating end-to-end capabilities from archival storage to non-destructive file access for reading, erasing, rewriting and computing.

Controlling RNA and protein condensation is helpful in synthetic biology. Here the authors show programmable assembly of synthetic RNA nanostructures into designer membrane-less organelles that selectively recruit ligands via protein-binding aptamers.

The authors present nanoscale DNA origami tension sensors tethered to lipid membranes and reveal the magnitude, dynamics and driving mechanisms of molecular forces experienced by immunoreceptors at fluid membrane junctions.

In this study, the authors present the design and fabrication of reusable, atomically thin, coupled bilayer solid-state nanopores that enable the slowing down and positional tracking of molecules for label-free, single-molecule sensing.

This Article presents a single-molecule ‘synthesis by sensing’ approach that enables in situ stepwise generation of stereo- and regio-defined heteromeric nanopores to resolve structural and chiral differences of amino-acids in single peptide stereoisomers.

A new acid-degradable linker termed ‘azido-acetal’ has been developed that rapidly hydrolyses at pH 6.0 but is stable at pH 7.4. Lipid nanoparticles made with this linker delivered mRNA in vivo and in vitro better than traditional lipid nanoparticles.

A metabolic-enzyme-like nanocatalyst is reported, dubbed ‘artificial metabzyme’. Tumour cells can be metabolically reprogrammed to autonomously modulate and interact with immune cells, facilitating tumour-cell-specific metabolic therapy.

The photobleaching property of heptamethine cyanine enables efficient charge conversion of nanoparticles. Here heptamethine-cyanine-based nanoparticles achieve specific tumour imaging, deep tumour penetration and high therapeutic efficacy in rectal cancer animal models.

Delivering immunomodulatory compounds to myeloid cells can activate innate immunity for cancer immunotherapy. Here the authors design a polymersome-based nanocarrier for delivering β-glucan to red pulp myeloid cells in the spleen and show that their strategy achieves tumour growth reduction in a melanoma model.

This study shows how amino acid composition and topology in synthetic polypeptides affect anti-inflammatory effects and how scavenging debris nucleic acids inhibits inflammation and relieves symptoms of autoimmune diseases.