Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
This study shows changes in microglia-vascular interactions in the context of heart failure, which unveils a novel potential therapeutic target for mitigating neuroinflammation in cardiovascular diseases.
Ultrastructural mapping of the human vagus nerve and compound nerve action potential predictions to vagus nerve stimulation suggest that vagal projectome features, including laterality, sexual dimorphism, and heterogeneity, shape neuromodulation.
Even spectrally non-overlapping noise impairs vibrational communication in the model insect species Nezara viridula, revealing a non-conventional masking mechanism and a potential for disruption of insect communities by anthropogenic noise.
This study examines how periodic stimuli affect neural activity and behavior. EEG data from a Go-NoGo task show that task periodicity influences the brain’s power spectrum, reducing neural complexity and improving reaction time and response bias.
In the mouse ovary, dietary phytosterols are shown to inhibit ovarian folliculogenesis and to reduce egg quality by enhancing PRC2-mediated histone H3 trimethylation.
Acidification and warming enhance the productivity and nutrient assimilation of Pocillopora damicornis coral larvae, without destabilizing its symbiosis with intracellular algae.
Multi-tissue transcriptomic analysis reveals how variability in parental behavioral tolerance and environment shape rapid acclimation to ocean acidification in a coral reef fish.
A study explores how purple bacteria adapt metabolically to cathodic bioelectrochemical conditions. Rhodopseudomonas is found to be the primary electron mediator, enhancing CO2 uptake and PHA accumulation in the consortium.
KDM2B modulates the OGT-mediated O-GlcNAcylation of SLC7A11 via the ubiquitination pathway, thereby promoting neuronal ferroptosis and exacerbating stroke injury in mice.
Psoriatic human skin equivalents provide a 3D in vitro test environment with in vivo-like cutaneous responses to anti-inflammatory compounds or biological antibody therapy qualifying them as tools for preclinical treatment studies.
scRNA-seq revealed an intraductal heterogeneity of human pancreatic organoids paving the way to new potential applications of this new technology in developmental biology, regenerative medicine and drug development.
Functional characterization of the nucleus- and spindle-associated protein NuSAP4 identifies its essential roles in regulating spindle dynamics in the early divergent protozoan Trypanosoma brucei
The Ca2+ ion channel Orai1 plays an important role in T-cell activation. A charged amino acid side chain close to the center of Orai1-transmembrane domain (TM)3 or -TM4 triggers robust constitutive activity due to enhanced hydration and widening of peripheral TM-interfaces.
The mouse mammary tumor virus (MMTV) encodes a gene transactivation system similar to HIV Tat/TAR-HTLV Tax/TRE that requires a yet-to-be identified virally-encoded factor and the cellular factor pTEF-b for function.
Chrysalis, a machine learning-based framework accurately infers cellular niches and underlying gene expression programs in the tissue from spatial transcriptomics data. It demonstrates robust performance on a diverse set of tissues and platforms.
Echinoderms are a diverse phylum of marine invertebrates that possess a unique type of connective tissue: Mutable Collagenous Tissue (MCT); evidence of MCT in the feeding structures of an extinct class of echinoderms, the Blastoidea, is presented.
Combining dynamic amplitude modulated stimuli with spectrally specific analyses yield rapid and robust diagnostic metrics for neural assessment of auditory temporal processing across multiple mammalian species.
