Trilobite cephalic shape disparity decreases through the Palaeozoic, with peaks in the Ordovician and Devonian caused by different underlying mechanisms, though occurrence data cannot generally be predicted for trilobites using just cephalic shape.

We used 3D bioprinting to create a full-thickness human skin model with a hypodermis layer, offering an in vitro tool for disease and toxicology studies. This model replicates skin function and highlights the hypodermis’ role in tissue development.

Brain-wide activity patterns show stronger links to personality traits under certain task-contexts than others. These results emphasize the importance of situational factors in finding reliable brain-trait relationships.

Multivariate analysis of hyperspectral Raman imaging data unveils severe cellular toxicity and lipid dysregulation in the chemically complex Aβ plaque microenvironment.

Bioinformatic and biochemical analyses provide insight into the ubiquitous Sugar Phosphate Utilizing BMC and its role in catabolizing DNA-degradation products through its signature aldolase enzyme.

Endogenous lipid nanoparticles as well as synthetic nanoparticles coated with ceramide provoke strong vacuolization in microglia as seen in neurodegenerative diseases, like Alzheimer’s disease.

Ibetazol, a novel compound efficiently and specifically inhibiting all importin β1-mediated nuclear import, will be a valuable tool for fundamental research into importin β1-mediated nuclear import mechanisms and a therapeutic lead in human diseases.

Biophysical and structural characterization of the TRAP transporter SBP SiaP in complex with a nanobody provides insights into an allosteric mechanism of inhibition.

Generation of a midbrain-striatum assembloid with progerin overexpression as an in vitro model of possessing aging and senescence characteristics for studying Parkinson’s disease.

A study in zebrafish identifying orthologs of mammalian glucokinase isoforms shows physiological responses to nutrition and disrupted responses under diabetic conditions, which are improved by treatment with the glucokinase activator Dorzagliatin.

‘Candidatus Endonucleobacter’ infects the nuclei of deep-sea mussels but it was unknown how they can prevent apoptosis of the host. A new study by Porras and colleagues, published in Nature Microbiology, suggests that the bacterium upregulates host-derived apoptosis inhibitors and genes for digesting sugars, lipids and amino acids acquired through horizontal gene transfer from the mussels.

This paper is a call to action. By publishing concurrently across journals like an emergency bulletin, we are not merely making a plea for awareness about climate change. Instead, we are demanding immediate, tangible steps that harness the power of microbiology and the expertise of researchers and policymakers to safeguard the planet for future generations.

A Comment on the transformative progress of artificial intelligence for structural and protein biology, referencing the 2024 Nobel Prize in Chemistry.

A study on African lions in Uganda’s Nile Delta shows wildlife tourism rangers, an often-forgotten group in the scientific process, deliver strong density estimates. The study also shows infrared camera traps are weak at detecting lions.

This Comment reviews a recent workshop that aimed at improving funding outcomes for consciousness science researchers. The most essential pieces of advice for early career consciousness scientists are summarized.

Light scattering, resulting from refractive index mismatch, is the primary factor limiting imaging depth in biological tissue. In a study recently published in Science¹, Ou et al. took an unconventional approach and employed highly absorbing molecules, such as food dye tartrazine, to increase the refractive index of water in the near-infrared wavelength range, which rendered tissue transparent in live mice.