Search Results (130,179)

Background/Objectives: Chronic pain impacts approximately 18% of the Spanish population, with low levels of vitamin D prevalent in over 80% of individuals over 65. Given vitamin D’s critical role in pain modulation, its deficiency may be significantly linked to chronic musculoskeletal pain, though existing research offers mixed results. Methods: This systematic review followed PRISMA guidelines, examining studies from PubMed, Cochrane, and PEDRO databases from 1990 onwards that investigated the relationship between vitamin D levels and chronic musculoskeletal pain. Results: A total of 30 studies met the inclusion criteria set by the NHLBI’s quality standards. The results are inconclusive regarding the direct relationship between vitamin D levels and chronic musculoskeletal pain due to evidence heterogeneity. However, there appears to be an inverse relationship between vitamin D levels and the intensity of pain. Conclusions: While the association between vitamin D levels and chronic musculoskeletal pain remains uncertain, the inverse correlation with pain intensity suggests a potential therapeutic role of vitamin D supplementation in pain management. Further research is needed to substantiate these findings and refine intervention strategies. Full article

Itraconazole (ITZ), a broad-spectrum triazole antifungal agent, exhibits remarkable pharmacodynamic and pharmacokinetic properties. However, the low solubility of ITZ significantly reduces its oral bioavailability. Furthermore, it has been reported that this medication can result in dose-related adverse effects. Therefore, the objective of this study was to enhance the solubility of ITZ through the utilization of various polymers and to manufacture personalized and programmable release ITZ tablets. Five different polymers were selected as water-soluble carriers. Thirty percent w/w ITZ was mixed with seventy percent w/w of the polymers, which were then extruded. A series of physical and chemical characterization studies were conducted, including DSC, PXRD, PLM, and in vitro drug release studies. The results demonstrated that ITZ was dispersed within the polymers, forming ASDs that markedly enhanced its solubility and dissolution rate. Consequently, soluplus^® was employed as the polymer for the extrusion of ITZ-loaded filaments, which were subsequently designed and printed. The in vitro drug release studies indicated that the release of ITZ could be regulated by modifying the 3D structure design. Overall, this study found that the combination of HME and 3D printing technologies could represent an optimal approach for the development of personalized and precise drug delivery dosages. Full article

Reconstructing the orbit following complex craniofacial fractures presents significant challenges. Throughout the years, several materials have been used for orbital reconstruction, taking into account factors such as their durability, compatibility with living tissue, cost efficiency, safety, and capacity to be adjusted during surgery. Nevertheless, a consensus has not yet been reached on the optimal material for orbital restoration. This study investigates the potential of a hybrid hydroxyapatite–collagen (HAp-COL) material 3D-printed on Ti mesh to be used as an implant for orbital wall reconstruction. HAp-COL powder was synthesized using a high-pressure hydrothermal technique. The powder was further used to 3D-print HAp-COL structures on titanium mesh, with the latter having potential uses in orbital wall reconstruction. Biocompatibility was assessed by evaluating the effects of the HAp-COL material on the adhesion and proliferation of fibroblasts (3T3) and mesenchymal stem cells (MSCs) in culture. In vitro and in vivo results showed that HAp-COL is highly biocompatible and has a good integration of the implant in the bone. The findings reported in this study offer convincing evidence to support the use of our designed HAp-COL for the restoration of orbital wall fractures, with a high level of safety. Full article

Background: Pregnancy is a crucial period for maternal and fetal health, and in Lebanon, where cultural and economic factors influence dietary practices, there is an urgent need to evaluate the food consumption patterns and diet quality of pregnant women. Aim: To evaluate the food consumption patterns, energy intake, as well as macro- and micro-nutrient intake among a nationally representative sample of Lebanese pregnant women aged 18–49 years old. Methods: A cross-sectional study was carried out from March to October 2023, involving 500 pregnant women from all eight Lebanese governorates. Sociodemographic and medical information was gathered, food consumption was evaluated using a validated Food Frequency Questionnaire (FFQ) and three 24-h recall, and anthropometric measurements were recorded. Results: The current population did not meet the USDA healthy pattern recommendations for whole grain, seafood, dairy, nuts, seeds and soy products consumption but exceeded the guidelines for vegetables, meats, poultry, eggs, oils, and refined grains. According to Mediterranean diet guidelines, the sample fell short in recommended intakes for fruits, olives/nuts/seeds, eggs, and olive oil, while surpassing the recommended levels for potatoes, legumes, pulses, sweets, red meat, processed meat, and fish and seafood. None of the participants met the energy requirements for their trimester and age group. In terms of macronutrient intake, the requirements for protein, unsaturated fats, and fiber were not met, while intakes of fats and sugars were exceeded. Regarding micronutrients, the recommended levels were not fully achieved, with particularly low intakes of vitamin D and iodine, as well as inadequate adherence to recommendations for iron, calcium, vitamin A, vitamin E, zinc, and choline. Additionally, a third of the participants did not meet the recommended intakes for folate and vitamin B12. Conclusions: The findings reveal significant dietary inadequacies among the current population, with participants failing to meet essential recommendations for whole grains and key food groups, alongside insufficient energy intake for their trimesters and age groups. Critical micronutrient deficiencies, particularly in vitamin D, iodine, and B vitamins, highlight the urgent need for targeted nutritional interventions and public health initiatives to improve dietary practices among pregnant women in Lebanon. Full article

Underground compressed air energy storage chambers are a promising emerging energy storage technology with strict limitations relating to the stability of the surrounding rock. This study conducted displacement and plastic zone analyses during the excavation and stabilization phases of the chamber utilizing the finite difference method based on engineering data, demonstrating that the stability of salt rock can effectively withstand internal pressures ranging from 0 to 9 MPa, with an average of 15 mm in the Z-axis and 19.23 mm in the X-axis. To further investigate the feasibility of subterranean energy storage reservoirs, the FOS for various surrounding rocks was calculated at different burial depths. These results facilitated a parameter sensitivity analysis on the stability of the surrounding rock of the underground energy storage reservoir. The dynamic reaction of the underground chamber was studied using synthetic seismic wave technology, demonstrating that the seismic capacity of the structure adhered to the code, and the post-seismic displacement remained within the safe range (Z-axis 34 mm, horizontal 19 mm). The results demonstrate the stability analysis method of the chamber and establish a foundation for the extensive implementation of CAES which will contribute to the development of energy storage technology. Full article

Mechanical asphyxia presents a challenging diagnostic issue in forensic medicine due to its often covert nature, and the signs visible during an autopsy are usually not specific. Despite some progress in understanding hypoxia’s effects, traditional methods’ inherent limitations might overlook new biomarkers in mechanical asphyxia. This study employed 4D-DIA proteomics to explore the protein expression profiles of cardiac samples under conditions of mechanical asphyxia. Proteomic analysis identified 271 and 371 differentially expressed proteins in the strangulation and suffocation groups, respectively, compared to the control group. Seventy-eight differentially expressed proteins were identified across different mechanical asphyxia groups compared to the control group. GO and KEGG analysis showed enrichment in pathways, including complement and coagulation cascades, cAMP and cGMP-PKG signaling pathways, inflammatory mediator regulation of TRP channels, and phagosomes. Through stringent selection based on protein interactions, ALKBH5, NAA10, and CLPB were identified as potential diagnostic biomarkers. ALKBH5 showed increased expression in asphyxia models, while NAA10 and CLPB were downregulated; these biomarker changes were validated in both animal models and human cardiac samples. This study highlights the potential of proteomics in discovering reliable biomarkers, which can enhance the specificity of mechanical asphyxia diagnosis in forensic practice, provide new insights into the pathophysiological mechanisms of mechanical asphyxia, and offer new perspectives for diagnosing mechanical asphyxia. Full article

This study investigates the use of spoof surface plasmon polaritons (SSPPs) as an effective feeding mechanism for antennas functioning within the extremely high-frequency (EHF) range. A novel method is proposed for feeding a dielectric rod antenna with SSPPs, featuring a simple design made from FR-4 material with a relative permittivity of 4.3. In contrast to traditional tapered dielectric rod antennas and their feeding configurations, this design shows promise for achieving a gain of up to 16.85 dBi with an antenna length of 7.6 λ₀. By carefully optimizing the design, impedance matching and directional radiation characteristics were obtained at 7.3 GHz. Simulations were conducted using CST Microwave Studio to validate and evaluate the design’s performance. The enhanced gain, improved impedance bandwidth, and use of cost-effective materials such as FR-4 present a compelling case for adopting this design in future wireless communication technologies. Additionally, the remote sensing properties of the feeder can be utilized for concealed object detection, material characterization, and the analysis of the spectral properties of materials. Full article

Background/Objectives: This study tested the influence of in vitro digestion on the release of organic acids and low molecular weight saccharides of matcha. Methods: The concentrations of analytes in the raw and undigested portion of matcha were measured using HPLC with spectrometric and refractometric detection to establish their residual values after a two-step enzymatic digestion that was finally presented as a retention factor. Results: It was established that dry matter digestibility values after simulated gastric and both gastric and intestinal phases were 67.3 and 85.9%, respectively. Native matcha, citric acid (44.8 mg/g), malic acid (32.2 mg/g), trehalose (36.1 mg/g), and L-arabinose (8.20 mg/g) reached the highest values and were predominant, whereas D-fructose, xylose, maltose, and saccharose were not detected. Regarding gastric phase digestion, succinic and malic acids, trehalose and D-glucose were the worst-releasing compounds and their remaining factors reached 34, 19, 18, and 50%, respectively, whereas L-arabinose was completely released. Focusing on gastric and small intestinal digestion, the least-releasing compounds of matcha tea leaves were succinic acid and trehalose, with their retention factors at 7 and 13%, which can proceed with the leaf matrix to the large intestine. Conclusions: Malic, oxalic, and citric acids, the carbohydrates D-glucose, L-arabinose, and L-rhamnose, are almost entirely released from matcha tea during digestion in the stomach and small intestine and can be available for absorption in the small intestine. In the measurement of oxalic acid, considering that the process of shading tea leaves increases the concentration of this acid and its retention factor value is too small, it would be appropriate in the future to evaluate the recommended maximum daily intake of matcha tea for people sensitive to the formation of urinal stones. Full article

A novel series of substituted benzofuran-tethered triazolylcarbazoles was synthesized in good to high yields (65–89%) via S-alkylation of benzofuran-based triazoles with 2-bromo-N-(9-ethyl-9H-carbazol-3-yl)acetamide. The inhibitory potency of the synthesized compounds against SARS-CoV-2 was evaluated by enacting molecular docking against its three pivotal proteins, namely, M^pro (main protease; PDB ID: 6LU7), the spike glycoprotein (PDB ID: 6WPT), and RdRp (RNA-dependent RNA polymerase; PDB ID: 6M71). The docking results indicated strong binding affinities between SARS-CoV-2 proteins and the synthesized compounds, which were thereby expected to obstruct the function of SARS proteins. Among the synthesized derivatives, the compounds 9e, 9h, 9i, and 9j exposited the best binding scores of −8.77, −8.76, −8.87, and −8.85 Kcal/mol against M^pro, respectively, −6.69, −6.54, −6.44, and −6.56 Kcal/mol against the spike glycoprotein, respectively, and −7.61, −8.10, −8.01, and −7.54 Kcal/mol against RdRp, respectively. Furthermore, the binding scores of 9b (−8.83 Kcal/mol) and 9c (−8.92 Kcal/mol) against 6LU7 are worth mentioning. Regarding the spike glycoprotein, 9b, 9d, and 9f expressed high binding energies of −6.43, −6.38, and −6.41 Kcal/mol, accordingly. Correspondingly, the binding affinity of 9g (−7.62 Kcal/mol) against RdRp is also noteworthy. Furthermore, the potent compounds were also subjected to ADMET analysis to evaluate their pharmacokinetic properties, suggesting that the compounds 9e, 9h, 9i, and 9j exhibited comparable values. These potent compounds may be selected as inhibitory agents and provide a pertinent context for further investigations. Full article

The main method for assessing the seismic resistance of buildings in the standards of most countries is the linear-spectral method. This method allows for the calculation of the spatial model of a building for seismic load in the elastic range without resorting to direct integration of the equations of motion. Nonlinear characteristics of reinforced concrete structure materials are usually considered integrally using the reduction factor. However, the values of this factor in the Russian standards are not sufficiently substantiated, as the later studies show. To determine the coefficient of permissible damage (reduction factor), six reinforced concrete frames were considered, with different parameters such as span length, number of spans, and number of floors. The design parameters of beams and columns (section sizes, reinforcement, etc.) were preliminarily selected based on the calculation using the linear-spectral method. In the second stage, numerical modeling was carried out in the OpenSEES PC to implement the pushover analysis procedure. Then, the coefficient of permissible damage was estimated by processing the capacity curves obtained on the basis of nonlinear static calculation. The value of the sought coefficients is practically not affected by the number of stores of the frame; however, with an increase in the number of spans, the coefficient K₁ increases, which is explained by a decrease in the plasticity of the system. On average, for the frames under consideration, the coefficient K₁ was 0.526, which is 1.5 times greater than the coefficient proposed in modern Russian standards, K₁ = 0.35. The results obtained on the basis of pushover analysis are compared with the coefficients K₁ determined through the values of the average degree of damage (d) of the buildings according to the modified seismic scale MMSK-86. For various types of reinforced concrete frame buildings, K₁ = 0.51 was obtained. It is recommended that the coefficient K₁ for reinforced concrete frame buildings should be increased to a value of at least K₁ = 0.5 in the Russian standard. Full article

The paper is devoted to the analysis of a supersonic nozzle system effect in gas-cooled lances on the technological parameters of slag splashing in an oxygen converter. Simulation calculations were carried out, taking into account the parameters of nozzles used in the technological lines of converter steel plants in Ukraine and Brazil. The problems were solved in several stages. The simulation results of the first stage revealed the influence of different nozzle diameters d_cr, d_ex and the inlet pressure before nozzle P₀ on the nitrogen consumption of one nozzle V_н. Calculations also showed the influence of the critical d_crand output d_ex of the nozzle diameter and nitrogen flow through one nozzle V_н on the power of injected nitrogen N₁ and the depth of penetration of the stream h_x into the liquid slag. The second stage was dedicated to numerical simulation of the slag splashing process, including an array of results from the first stage. The thermodynamic and physical parameters were calculated using our own computer program, while 3D simulations were conducted using the ANSYS Fluent 2023 R2 program. Full article

The symmetry for two-dimensional (2D) dispersionless Toda lattice hierarchy (dTLH) is firstly derived, and then the 2D dTLH is extended based on the symmetry constraint. The commutativity of two different flows for this new hierarchy is shown, which leads to the 2D dToda lattice equation with self-consistent sources (dTLESCSs) together with its conservation equation. The hodograph solutions to 2D dTLESCSs are also given. One dimensional reduction of extended 2D dTLH is finally investigated by finding the constraint, and a one-dimensional dTLESCS is shown. Full article

This study investigates the modification of bituminous mixtures by varying percentages of PET particles (1%, 3%, 5%, 8%, 10%, and 12% PET). The following methods were employed to analyze the samples: the ring-and-ball softening point determination method (ASTM D36/D36M-14), the Fraass breaking point determination method (EN 12593: 2015), the elongation determination method (EN 13589: 2014), and the needle penetration depth determination method (EN 1426: 2015). Optimal bitumen/PET ratios were identified to obtain modified bituminous mixtures (MBMs) with enhanced operational characteristics (5% and 8% PET). The physical and mechanical properties of the investigated bitumen samples and PET were determined. A comparative analysis of the modified bituminous mixture samples based on their physical and mechanical properties was conducted. Microstructures of the surface of modified bituminous mixture samples with varying modifier contents were obtained. An X-ray structural analysis was performed on the samples of modified bituminous mixtures with varying PET contents. The dependencies of the moisture absorption rate on time were determined for the samples of modified bituminous mixtures with different modifier contents. The values of the stress intensity factor were determined based on the number of loading cycles in fatigue tests using three-point bending for the samples of modified bituminous mixtures with varying modifier contents. Full article

Currently, research on composite materials derived from natural fibers and agro-industrial waste has generated industrial proposals for producing useful materials with sufficient mechanical strength for applications involving the reuse of waste for secondary purposes. The objective of this study was to determine the influence of fiber content on the final tensile strength of the composite material, serving as a reference for the manufacture of plates. To achieve this, high-density polyethylene (HDPE) composites reinforced with short banana fibers were prepared using a blade mill and hot compression molding techniques. Two levels of short banana fiber content—10% and 20% by weight—were used, along with two types of HDPE: virgin and recycled. We evaluated the effect of adding short banana fibers on the mechanical properties of the composite, specifically tensile strength, according to the ASTM D638 standard for polymeric materials. These results were correlated with the structural properties obtained through morphological, chemical, and thermal characterization of the developed materials. The mechanical evaluation results showed that the tensile strength and elastic modulus depend on the short banana fiber content and the type of high-density polyethylene. Thermogravimetric analysis revealed that the composites decompose faster than the pure polymers (virgin and recycled HDPE). Based on these findings, the composite material prepared under optimal conditions is recommended for use in walls or construction boards where high tensile strength is not critical, due to the decreased mechanical properties resulting from the incorporation of agro-industrial waste. Full article

The Megafauna3D project integrates advanced 3D scanning technologies and paleontological research to bring the extinct megafauna of Uruguay to formal and informal educational settings. Through the use of digitized fossil models, interactive education materials, and a web platform, the project engages the public and educational institutions in understanding the country’s paleontological heritage. This manuscript presents Megafauna3D’s multidisciplinary approach, its outreach initiatives, and the educational resources developed, such as 3D models and printed replicas, a book integrated with augmented reality, fanzines, and a teaching box. With a focus on open science, inclusivity, and accessibility, the project fosters public engagement with paleontological content and promotes fossil heritage conservation. Full article