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Plants
Special Issues
Emerging Phytochemicals: Novel Compounds, Extraction Techniques, and Potential Therapeutic Applications
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Emerging Phytochemicals: Novel Compounds, Extraction Techniques, and Potential Therapeutic Applications

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 520

Special Issue Editors

Dr. Felipe Moura de Moura Souza

E-Mail Website
Guest Editor
Ciência e Tecnologia Goiano, Campus Rio Verde, Instituto Federal de Educação, Morrinhos, Brazil
Interests: phytochemicals; green chemistry; essential oils; electrochemistry; electroanalytics
Dr. Antonella Smeriglio

E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (CHIBIOFARAM), University of Messina, Via SS Annunziata, 98168 Messina, Italy
Interests: natural compounds; polyphenols; plant extracts; pharmacognosy; functional foods; nutraceuticals; pharmacology; toxicology; antioxidant activity; anti-inflammatory activity; cytoprotective activity; clinical studies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue "Emerging Phytochemicals: Novel Compounds, Extraction Techniques, and Potential Therapeutic Applications", aims to explore the frontier of phytochemical research, focusing on novel compounds, advanced extraction techniques, and their potential therapeutic applications. With the rapid development of natural product chemistry, new phytochemicals with significant biological activities are being discovered, offering promising avenues for therapeutic intervention. This issue seeks contributions that highlight innovative methodologies for the extraction and characterization of these compounds, as well as studies elucidating their mechanisms of action and potential benefits in treating various diseases. By bringing together cutting-edge research, this Special Issue aims to provide a comprehensive overview of the current state and future perspectives in the field of phytochemicals, fostering collaboration and knowledge exchange among researchers and practitioners.

Dr. Felipe Moura de Moura Souza
Dr. Antonella Smeriglio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phytochemicals
  • extraction techniques
  • therapeutic applications
  • nature compounds

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Published Papers (1 paper)

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Research

17 pages, 1322 KiB  
Article
Comparative Study of Phenolic Content and Antioxidant and Hepatoprotective Activities of Unifloral Quillay Tree (Quillaja saponaria Molina) and Multifloral Honeys from Chile
by Paula Núñez-Pizarro, Gloria Montenegro, Gabriel Núñez, Marcelo E. Andia, Christian Espinosa-Bustos, Adriano Costa de Camargo, Juan Esteban Oyarzún and Raquel Bridi
Plants 2024, 13(22), 3187; https://doi.org/10.3390/plants13223187 - 13 Nov 2024
Viewed by 366
Abstract
Honey is a natural sweet element that bees make with flower nectar, revered for its distinct flavor, nutritional value, and potential health benefits. Chilean beekeeping has a diverse range of honey varieties, many of which are unique. The quillay (Quillaja saponaria Molina, [...] Read more.
Honey is a natural sweet element that bees make with flower nectar, revered for its distinct flavor, nutritional value, and potential health benefits. Chilean beekeeping has a diverse range of honey varieties, many of which are unique. The quillay (Quillaja saponaria Molina, soapbark tree) is a Chilean endemic tree whose honey has not been studied in depth. We characterized various Chilean honeys with different botanical origins, with a particular focus on quillay tree honey, analyzing its total phenolic and flavonoid content and its antioxidant activities. Cytotoxicity and hepatoprotective activity were also evaluated using HuH-7 cells. The Spearman correlation between the percentage of quillay pollen in the honey samples and the total phenolic content (R = 0.72; p < 0.05), plus the oxygen radical absorbance capacity, suggests that compounds from quillay contribute to the overall antioxidant capacity of honey. Unifloral quillay honey extracts also protect hepatic cells from oxidative damage induced by peroxyl radicals generated by AAPH. This analysis sheds light on the potential of quillay tree honey, underscoring its significance as a natural source of bioactive phenolic compounds with possible hepatoprotective effects. Full article
(This article belongs to the Special Issue Emerging Phytochemicals: Novel Compounds, Extraction Techniques, and Potential Therapeutic Applications)
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Figure 1

Figure 1
<p>Heat map analysis for parameters studied in all honey samples (%: percentage of quillay pollen; TPC: total phenolic content; TFC: total flavonoid content; ORAC-FL: oxygen radical absorbance capacity; FRAP: ferric reducing antioxidant power).</p> Full article ">Figure 2
<p>Honey samples’ cytotoxicity. Cell viability was evaluated by Alamar blue of HuH-7 cells treated for 24 h with honey extract of the test sample (sample 9) at different dilutions (0.005, 0.05, 0.5, 5, and 50 mg/mL). To control cell death, cells were treated with Triton X-100 at 1% for 10 min. Data are expressed as the percentage of viability with respect to the control cells. AU, arbitrary units. Data are shown as mean ± SD (n = 3). A one-way ANOVA statistical test was performed, followed by the Tukey test. Statistically significant differences compared to the control group (cells without treatment) (** <span class="html-italic">p</span> &lt; 0.01).</p> Full article ">Figure 3
<p>AAPH-induced cell death. Cell viability was evaluated by Alamar blue of HuH-7 cells treated with 2,2′-Azobis (2-amidinopropane) dihydrochloride (AAPH) for 24 h at different concentrations (0.02–2000 μM). For cell death control, cells were treated with Triton X-100 at 1% for 10 min. Data are expressed as a percentage of viability with respect to the control cells. Data are shown as mean ± SD (n = 3). AU, arbitrary units. A one-way ANOVA statistical test was performed, followed by the Tukey test. Statistically significant differences compared to the control group (cells without treatment) (* <span class="html-italic">p</span> &lt; 0.05).</p> Full article ">Figure 4
<p>Honey extracts prevent AAPH-induced cell death. Cell viability was evaluated by Alamar blue of HuH-7 cells treated with quillay honey extracts (samples 8, 9, 10, 11, and 12) at different dilutions (0.005, 0.5, and 50 mg/mL at the final concentration in the medium) and co-treatment with 2,2′-Azobis (2-amidinopropane) dihydrochloride (AAPH) for 24 h at 200 μM. To control cell death, cells were treated with Triton X100 at 1% for 10 min. Data are expressed as a percentage of viability compared to the control group (untreated cells). AU, arbitrary units. Data are shown as mean ± SD (n = 3–5). A one-way ANOVA statistical test was performed, followed by the Tukey post hoc test. Statistically significant differences compared to the cells treated only with AAPH (** <span class="html-italic">p</span> &lt; 0.01).</p> Full article ">
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