Biofunctional Pharmaceutical Additives for Targeted, Improved Bioavailability and Safety of Medicine
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 10098
Special Issue Editors
Interests: preformulation studies; cyclodextrins; solubility enhancement; modified release systems; niosomes; ocular delivery; irritation models
Special Issues, Collections and Topics in MDPI journals
Interests: drug delivery; cancer; pancreatic diseases; bioprinting; biosensor; nanotechnology
Special Issues, Collections and Topics in MDPI journals
Interests: cancer nanomedicine; cytoplasmic drug delivery; targeted drug delivery; blood-brain barrier; ligand functionalised nanoparticles; liposomes; exosomes; extracellular vesicles
Special Issue Information
Dear Colleagues,
Conventional pharmaceutical excipients have been used to alter palatability, processing ability, flowability, and compressibility of dosage forms during manufacturing stages for producing elegant pharmaceutical products. Typical examples of these excipients include diluent, disintegrant, binder, lubricant, and glidant. Other pharmaceutical ingredients/excipients have been included to improve the chemical, physical, and microbial stability of the dosage forms. The literature has reported many drug–excipient incompatibilities and excipients-related side effects such as local irritation, interference at the absorption sites through affecting efflux pumps and g-glycoproteins, and other systemic toxicities.
With the recent advances in pharmaceutical and medical sciences, active pharmaceutical agents have been launched into the market with inherent poor biopharmaceutics properties such as low solubility and limited permeability. Erratic drug absorption, inconsistent bioavailability, irritation, and poor pharmacokinetics may occur, leading to suboptimal efficacy and adverse drug reactions.
Biofunctional excipients have recently emerged, such as smart polymers, lipids, and other safe and natural additives that can alter drug solubility, release characteristics, permeability, and pharmacokinetic profiles. Typical example include in situ forming polymers, amino acids, cyclodextrins, and many more.
The new knowledge obtained from novel research ideas and manuscripts will contribute to improving bioavailability, reducing adverse effects, achieving drug targeting, or promoting better patient treatment adherence.
The focus of this Special Issue is on recent developments in biofunctional non-active ingredients/excipients used to design pharmaceutical formulations and delivery systems (for topical or systemic routes) that could confer targeted drug delivery or modified drug release to enhance efficacy, reduce irritation at the absorption site, and beyond.
We would be much appreciating if you would consider being one of our authors contributing to this Special Issue. All types of submissions are welcome, including original research articles and comprehensive reviews.
Dr. Hamdy Abdelkader
Dr. Adel Al-Fatease
Dr. Zimei Wu
Guest Editors
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Keywords
- excipients
- in situ forming polymers
- modified-release
- cyclodextrins
- amino acids
- eye diseases
- diabetes
- cancer
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