In a southern city (Huainan, Anhui), the six sisters of the He family-He Jiali, He Jiawen, He Jiayi, He Jiahuan, Liu Xiaoling, and He Jiaxi, experience a life of joy and sorrow from the 1950s to the early 21st century. The story highlights the changing roles and strengths of women amidst the shifting tides of the era, reflecting the transformation of everyday life for ordinary families in the post-establishment of New China. As the decades unfold, the six sisters face love, friendship, family ties, and career challenges, growing together and ultimately understanding the true meaning of home.