CeeLo Green did not reprise his role as the voice of Murray the Mummy due to being arrested. Keegan-Michael Key replaced him in this film, same said for Hotel Transylvania 3: Summer Vacation (2018) and Hotel Transylvania 4: Transformania (2022).
The parents of Jonathan (Andy Samberg) are voiced by real-life husband and wife, Nick Offerman and Megan Mullally.
In many ancient cultures, notably Greek, people with red hair were believed to become vampires upon death. It is quite fitting therefore, that Johnny and Dennis have red hair. It is unknown, however, if this is an intentional reference.
This film takes place seven years after the first Hotel Transylvania (2012), and Dracula is 539 years old, Mavis is 125, and Jonathan is 28 years old.
Jonathan's vampire disguise outfit is modelled after Gary Oldman's elderly version of Dracula in Bram Stoker's Dracula (1992).