Blythe Baxter moves to the big city above the Littlest Pet Shop. She finds out she can talk to the pets in the shop and must save the shop from closing and turning into a sweet shop.
Pepper is unaware that her new stand-up comedy show routine might be offending the other pets; meanwhile, Blythe is persuaded to become friends with the Biskit twins.
Blythe and her dad take a trip to Hollywood with Vinnie in tow. The camera-shy Blythe is mistaken for a substitute dancer during a set visit to Vinnie's favorite dance show, and Vinnie gets his groove back from a local dance crew.
Famous movie star mongoose Shahrukh is in town shooting his next film and the pets go on set to visit their favorite star, but when Sunil is mistaken for Shahrukh, he's in for some excitement.
Zoe asks for Penny Ling to share her feelings about a pet shop camper named Digby. Meanwhile, Russell hides inside Blythe's backpack and gets lost at her school.
Blythe rescues the pets when they accidentally send a truck careening down the street, but when Blythe gets blamed, the pets decide to film a reenactment.
When Vinnie falls into a garbage can and is accidentally transported to the city dump the pets ask Blythe for her help, only to discover she can no longer understand them.
The pets try to retrieve a recipe stolen from Blythe by the Biskits, who plan to use it for a baking competition hosted at Blythe's school. Meanwhile, Vinnie has a vision of cakes occupying the world.
Blythe gets locked in a bathroom with Whittany Biskit, while back at the pet shop, the pets hear odd howling and try to find the "werewolf" among them.