Mindy is a 30 something Ob/Gyn whose love life hits a snag after a messy break up with her long term boyfriend. After getting drunk and making a scene at his wedding, Mindy vows to put the past behind her, find the perfect man and get her life on track.
Mindy wrestles with whether or not she should take things one step further with Josh. Meanwhile, Danny attempts to pass his driving test after failing countless times in the past.
Mindy spends Thanksgiving at Gwen's house, where she runs into her former blind date Dennis and his new girlfriend. Elsehwere, Jeremy is introduced to Betsy's family, and Danny spends the evening alone at the hospital.
When Mindy encourages a teenager in her building to take things slow with her boyfriend, she is forced to reflect on her own relationship with Josh. Meanwhile Danny becomes concerned after receiving an anonymous complaint.
Mindy is horrified when her younger brother visits and announces he is leaving college to embark on a career as a rapper. Meanwhile, Danny and Jeremy try to negotiate with the hospital's landlord.
When Gwen has to go to the emergency room, Mindy is forced to babysit her daughter. Meanwhile, Morgan, Betsy and Shauna uncover a secret whilst snooping in Danny's office.
Mindy tries to set up a one-night stand with Brendan after Jeremy encourages her to have a more adventurous sex life. Meanwhile, Danny goes on a date with Jillian.
Mindy meets a guy at a party but has suspicions about his extremely close relationship with his best friend. Meanwhile, Danny tries to win back Jillian after she dumps him for being too self-absorbed.
To put some distance between Jamie and Lucy, Mindy sets up Lucy on a Valentine's Day date with Danny, who is suffering from insomnia after his breakup with Jillian. Meanwhile, Morgan turns to Jeremy for advice on how to pick up women.
Danny tries to give Mindy advice when she is asked to host a medical segment on the local news. Beverly is re-hired at the hospital and struggles to keep up with modern technology.
Mindy gets back in touch with a former crush and tries to keep him from going back to the army. A married couple come to Danny with an unusual request.
Danny is caught by Morgan treating an old friend who isn't a patient of the hospital. Mindy tries to stop Heather from getting an apartment in her building.
A young Christian minister takes an interest in Mindy until he realizes they value different things in life. The hospital staff accidentally cause a riot when they visit a female prison.
Mindy accidentally hooks up with a male prostitute, and tries to help him with his dream to become a singer. Danny and Alex's small gathering turns into a party when Mindy finds out Danny did not want to invite her.
During a trip to Santa Fe for a medical conference, Mindy visits her ex-boyfriend Josh, who wants to make amends for his deceit. Jeremy and Morgan clash while preparing for the conference. Danny receives a shock when his ex-wife shows up at the hospital.
The hospital staff take part in a triathlon. Brendan and Duncan hire Morgan after Danny fires him for mailing a letter to his ex-wife. Mindy considers converting to Christianity for Casey.
Mindy takes on a young medical student to pass on her wisdom to and finds herself at a college frat party. Meanwhile, Danny and Jeremy try to get Morgan to return to Shulman and Associates'.
A camping trip in the woods makes Mindy contemplate whether she should go to Haiti with Casey, while Danny fears his reignited relationship with Christina is moving too fast.
