Trivia

When this event was played in theaters, there was a skit right before the feature began where Torgo delivers a pizza to Mike, Kevin, and Bill in a nod to the 1993 Mystery Science Theater 3000 episode. Torgo was played by a man named Rupert Talbot Munch Sr. (aka Phil Francis). According to a 2015 Playboy article, this happened only because Munch threatened legal action against Rifftrax over the live event, stating that Manos was still under copyright and that he represented those in control of that copyright. In exchange for letting the live event happen, Munch demanded he be able to appear in it in character as Torgo, and that clips from his then-in-production Manos sequel be shown during the end credits. All scenes of Munch were removed when the live event was released as a video-on-demand and DVD title. As of 2023, Munch's Manos sequel remains unfinished and unreleased.

Manos: The Hands of Fate was previously 'riffed' on Mystery Science Theater 3000 (1988), which Michael J. Nelson, Bill Corbett, and Kevin Murphy all previously worked on. The riffing script was completely rewritten for this live event.

The actor in the prune commercial is Olan Soule.