The show relies heavily on the use of CGI. Bandleader Reggie Watts has been quoted as saying, "Comedy Bang! Bang! without CGI would just be Omedy Ban! Ban!"
Scott Aukerman has said that the idea for the show came to him in a dream he had as a toddler.
The role of Scott Aukerman was originally written for Bruce Willis, but he had to turn it down due to scheduling conflicts.
There is at least one Easter Egg in every episode of the show, unlike its namesake podcast that has no eggs of any kind.
Scott Aukerman has mentioned in multiple interviews that for the taping of this show he would personally check each guest for head lice. A habit he picked up in his youth when working for his great uncle Caesar.