A scene from John Barrymore's production of Richard III was included in the early talkie Show of Shows (1929).
The original production of Barrymore opened at the Music Box Theatre on Broadway on March 14, 1997 and ran for 236 performance, closing on November 2, 1997. The original cast consisted of Christopher Plummer as John Barrymore and Michael Mastro as Frank. Plummer won a Tony and Drama Desk awards for best actor. The production then toured the United States with Plummer as Barrymore from July 6, 1998 to December 6, 1998.