Puppy in My Pocket: Adventures in Pocketville

I watched the whole series on Amazon's Prime Video.

Although I guess it's not Japanese, AFAIK, it's probably about as close as you can get to a truly clean Japanese anime TV show viewable in the USA (not counting anime movies like My Neighbor Totoro, Spirited Away, and Whisper of the Heart). Kuu Kuu Harajuku is another clean one (the first two-thirds of it that I've seen anyway; also not Japanese, but it's based in Japan and is kawaii). It's so hard to find clean anime. Most of the stuff people say is clean isn't very (like it has foul language, or sexual content, or violence, or creepy stuff, or whatever).

Puppy in My Pocket is uplifting. There are challenges. There are villains. There's no foul language. There's no sexual content. It's mostly just kids and animals (mostly animals). Violence is minimal, if it exists at all (there are ambush/trap scenes, kidknapping, and stuff). There's magic. The good characters are kind. The art is great. I like the voice artists. There's an overarching plot, but it seems to be targeted at kids (not teens, nor adults). It teaches morals. Most episodes follow a similar pattern, even though there is an overarching plot.

If you're comfortable with content of popular American cartoons from the 1980s and 1990s, it's about the same level of family-friendliness as that, but less violent and no romance.