Heart-rending, gut-wrenching adaptation by Larry Kramer of his own successful play about the foundation and formation in 1982 of the Gay Men's Health Crisis in New York City in the wake of what was then-called the Gay Cancer (now HIV/AIDS). Dramatization of events, with Mark Ruffalo's screenwriter Ned Weeks substituting for Kramer, is necessarily a no-holds-barred examination of gay sex in the '80s and its consequences, with the gay community themselves their own worst enemy (by being asked to abstain in the wake of more information on the disease, they felt oppressed as a modern culture and rebelled). In spite of an agonizingly long gestation period for this material (which Barbra Streisand optioned years ago, but was unable to finance), director Ryan Murphy has crafted an immediate and powerful document, alternately angry, sexy, tough, moving and thoughtful. Though "Longtime Companion" and the cable-film "And The Band Played On" have covered the AIDS epidemic (and done it extremely well), that does not lessen the impact of this HBO film, which packs an emotional wallop. Performances from Ruffalo, Julia Roberts, Alfred Molina, Matt Bomer, Jim Parsons and the entire cast are superlative.