Niña and Niño are siblings--- and at the same time, small time thieves. Their story starts 16 years ago when Niña is left under the care of her loving and religious grandmother Belen by their flighty and ambitious mother, Gloria.
Niña grows up to become a carefree and reckless woman brought about by her mother's rejection and abandonment. She thought the pain is gone until her mother's return, with a surprise in tow.
Niña finally meets her half-brother Niño. It was frosty and testy relationship until Niño's caring and loving attitude finally makes Niña realize that he is family.
Due to Niña's lapse in judgment, the siblings find themselves in jeopardy and the only way out is to escape their hometown and never to return. They find themselves stranded in a remote and strange place - Sta. Ynez.
Niña and Niño get entangled in the lives of the townspeople of Sta Ynez. They discover how spiritual and religious the people are, and also meet the town's hero --- a faith healer they call Ka Iking.
Niño attempts to leave Sta Ynez in the hopes of finding his way back to Consolacion. Meanwhile, Niña seems to have let go of her past life and enjoy her stay in Sta Ynez. Their relationship is once again on a rift.
Delia, with her crippled son Kaloy, arrive in Sta Ynez to seek help from Ka Iking. Friendship blossoms between Niño and Jen-Jen. While Niña discover Ka Iking's kept secret.
With Ka Iking gone, Niña grabs the opportunity to sell fake herbal medicines in order to make a living. Niño has no choice but to get along with her sister's plans.
Niño and Jen-Jen's new-found friendship with Kaloy will be put to test as the latter continue to feel insecure about himself. Something unexpected will spark between Niña and Gardo.
Niño meets an unfortunate accident. Niña is willing to do everything in order for her brother to survive, even if it means surrendering herself to God, something she has never believed in.
News of Niño's gift of healing starts to spread around Sta. Ynez, leaving the siblings in a quandary--- to help the people of the village or pursue their own personal plans?
Gardo, on Kap Pinang's wish, continues to fish information from Niña and Niño. However, Gardo can't stop his feelings for Niña. Meanwhile, a new danger is looming at Sta. Ynez.
Kap Pinang is doing everything to sabotage Niña and Niño's healing sessions. A mysterious man lurks at Sta Ynez, bringing fear among the town folks and to Niño.
The whole town worries that their healer, Niño's life would be endangered. In order to get Niña and Niño's affection, Kap Pinang orders a search for the mystery man.
Niña avoids the media at all cost. A seminarian comes to Sta Ynez to spend his discernment period, while an old grumpy woman wants to receive healing from Niño.
Niña and Niño discover that Lola Belen is suffering from a rare illness that makes her forget her memories about Niña. Meanwhile, the rivalry between Gardo and Bert escalates.
Niña's relationship with Lola Belen continues to fall apart no matter how hard she tries to save it, and it is starting to affect her relationship with Niño as well.
Jen-Jen is left alone as Pol decides to leave Sta. Ynez for a while. Niña and Niño, together with the other townspeople, are doing their best to help Jen-Jen recover.
As Jen-Jen leaves Sta Ynez alone, Niño is torn between taking care of Lola Belen and finding Jen-Jen. Niña on the other hand, is trying to balance her friendship with Kap Pinang and Isay.
Niña is starting fall in love with Gardo but Bert would not give up without a fight. Niño is being pushed away by Jen-Jen no matter how hard he tries to connect with her.