The glyphs for this episode spell out: PORTAL
"Thomas Jerome Newton" is the name assumed by a humanoid alien visitor to Earth in the 1963 novel "The Man Who Fell To Earth" by Walter Tevis. David Bowie played the part in the 1976 movie.
The Observer appears on the front square behind the white car when the FBI team are breaking into the men's public restroom.
The license plate on Olivia's Lincoln Navigator is 1C3PO1. It can be seen clearly as the truck goes through the gate by the guard shack at the beginning.
Another mystery substance, "Sirolomus", featured prominently in the episode, is derived from real-life drug Sirolimus, also known as Rapamycin, a substance discovered on the Easter Islands (Rapa Nui). It is a potent immunosuppressant used by transplant patients. More interestingly, it also seems to positively affect autism; however, its exact influence on brain cells and their metabolism is not yet fully researched.