Angela is told to remember the Amazon-Arkansas incident. This is referring to a real life murder investigation where the police attempted to use data recordings on an Alexa device to use as evidence against the suspect in 2015. In 2017 a judge ruled the evidence inadmissible and the charges against the suspect were dropped.
Unlike many productions filmed during the COVID-19 pandemic, this movie not only had to observe coronavirus restrictions and precautions behind the scenes during filming, it also explicitly acknowledges the pandemic onscreen as part of the storyline. Characters wear masks, and Angela admits in dialogue that the virus exacerbated her agoraphobia, which had been improving before COVID anxieties caused a relapse.
Steven Soderbergh directed this film, which takes place during the COVID-19 pandemic of 2019-2022. Soderbergh also received a flurry of publicity at the start of that pandemic when many recalled his movie Contagion (2011), noting its many similarities to the real-life pandemic then unfolding. In a May 2021 interview with the LA Times, Soderbergh said that he felt that making Contagion had prepared him for some of the medical realities of living through a pandemic but for few of the human responses to it: "It's been fascinating to see the aspects of this narrative play out that we didn't think about. The sociological behavior, how people have behaved as individuals, as states, as countries - that's been really fascinating. And something that very purposely, Scott Z. Burns and I were trying to keep the narrative very focused and we had rules about points of view and what we can see and what we couldn't see. But wow, there's a lot of really fascinating human behavior that we didn't even think about when we were doing this.... It's just a reminder of how deeply irrational we are. When we're put into some sort of fear-threat space, we become deeply illogical. It's crazy to witness."
Angela's medications are several benzodiazepines (anti-anxiety medications) and zopiclone (sleeping tablets).