Neku finds himself in an alternate, otherworldly Shibuya that is inhabited by monsters and has somehow become a Player in the Reaper's Game. As a Player, he will need to team up with others to complete the Game's missions or face erasure.
Entering the 4th day of the Reapers' Game, Neku begins to learn more about his partner, Shiki, as well as the reason behind why they are Players in the Game.
Neku learns that Players are people that are dead, but he struggles to remember how he died. As the Game nears its end, Neku and the others will have to try complete their last missions carefully if they want to be brought back to life.