It was suppose to release in April 2020, but got postponed because of covid-19. Later, it was sold to Hotstar.
It released on November 14, 2020 on Hotstar.
Director R J Balaji initially wanted to remake PK in Tamil, but later decided against doing so since the remake rights equalled his entire budget. Keeping the theme of PK in mind, which was about "the god that created us versus the god we have created", he wrote an original story which became Mookuthi Amman.
R J Balaji initially wanted an established actress like Anushka Shetty or Nayanthara to portray the title character, but did not approach them. He then narrated the story to Shruti Haasan, who liked it and said she would do the role. However, when Nayanthara called Balaji and liked the story he narrated to her, she agreed and was signed on.
Separate scenes involving actors Gautham Karthik and Manobala were shot but not included in the final cut.