Mei was the first artist to spread Beijing Opera to foreign countries, participating in cultural exchanges with Japan, the United States, and other regions. He toured the world, forming friendships with the western contemporaries of his day, including Charlie Chaplin. In 1930 he toured North America, visiting Hollywood, where he was welcomed by Douglas Fairbanks and Mary Pickford. In 1935, Mei toured Europe, playing to appreciative audiences in Berlin and Moscow. Seeing Mei perform especially impressed the German playwright Bertold Brecht and influenced his concept of the alienation effect. He served as one of the mentors and guardians of the actress Li Yuru as she began her career
In July 1937, the Marco Polo Bridge Incident occurred, and the Imperial Japanese Army soon occupied Beijing. The commander of the Japanese Army ordered Mei to perform for them and appointed Mei to a high rank official position. But Mei refused to sing throughout the duration of the war and endured an impoverished lifestyle until the war ended in 1945
China's official submission to 82nd Academy Award's Foreign Language category (2010).
In the year 1910, Mei married Wang Minghua, and they eventually had one son and one daughter together. While still married to Wang, he married his second wife in 1921, who was also an opera actress. Her name was Fu Zhifang and together, they had nine children. In 1925, he began seeing a third woman, who was also an actress. They lived together unmarried for five years before they finally broke up. Mei's daughter Mei Baoyue was a Chinese opera performer, and his son Mei Baojiu (1934-2016) was a Chinese opera dan performer