During the filming of the first scene, many of the neighbors were protesting the film because they believed it to be a pornographic film.
After Dawn has researched her "condition" online and hurriedly rides her bike, there are several pertinent suggestive signs visible on the streets, especially a number of close-ups of faceless bodies in underwear, but also a sign promoting a banana split.
Hale Appleman (Tobey) would later appear as a main character, in the TV show The Magicians (2015), as Eliot Waugh. In the episode, Do You Like Teeth? (2018), Eliot and his best friend Margo suggest to a character, that women have teeth in their vaginas that bite, an obvious lie. This may have been written into the script as a reference to his past work in this movie.
When speaking to her step brother Brad, Dawn is seen in a T-shirt with a unicorn decal on it. Unicorns represent both purity and virginity, major themes in the movie.
The movie John Hesley is watching in his room is "The Gorgon" (1965) with Christopher Lee, Peter Cushing and Barbara Shelley.