Jaden Yuki' is the only one out of the five main protagonist's (Yugi, Yu-Gi-Oh. Yusei, Yu-Gi-Oh 5D's. Yuya, Yu-Gi-Oh Arc V. and Yuma, Yu-Gi-Oh Zexal) that his first name doesn't start with the linitials Yu,
The second duel of Zane and Jaden is the only one that ends in a tie.
With the exception of Jaden, Syrus is the only character to be in all three dorms at the school.
Joey Wheeler in the original series was called a "Dueling Monkey" and when Jaden had a duel with the monkey taught to duel AKA the Dueling monkey, his name being Wheeler.
Starting from season 3, Syrus is noted to break the fourth wall on a number of occasions. Examples include: In "Snakes in the grass part 1" when Syrus offers Jaden water he had been carrying in a leaf, Jaden refuses. A disgruntled Syrus then says "I have been carrying this for 3 episodes!", which was indeed true He had admitted to not moving the plot along He acknowledged his sub-par duelling, but said "I know I'm not the star but come on, a little respect people"