Eddie Murphy declined to reprise his role as Dr. Dolittle for this film.
Originally intended to be released theatrically. It was even advertised as being released to theaters, until it was changed to Direct to Video shortly before release.
Last Dolittle movie where Kristen Wilson plays Lisa
The ranch rooster is called Cogburn. As a homage to John Wayne's character in 'True Grit'
The last Doctor Dolittle film to be distributed by 20th Century Fox.