For almost the whole movie the front door of the motel opens to the outside, but in the last few scenes (room wrapped in tin foil) the front door opens to the inside.
When Peter leaves the motel room to dispose of the smoke alarm, Agnes uses the bathroom with the door open and we see that the toilet is directly next to the open door. In later scenes, the sink is in the position directly next to the bathroom door.
Peter wraps the phone in plastic, but later when RC goes to make the aborted phone call she does not have to unwrap the phone. She merely picks it up and dials.
Throughout all the scenes in the motel where the bathroom is visible, we see that the bathroom door is a regular standard door. But in the scene when Peter is removing a tooth, as he goes to enter the bathroom the door changes into a double louvered door. Then changes back to the regular door in later scenes.
Near the end, when a pizza is delivered to Agnes and Peter, she takes some money and goes to the door : one can see she has a panties.
A few minutes later, when they undress themselves, Agnes just removes her nightie : her panties has disappeared already (and she never removed it before that last scene).
Peter hangs dozens of fly strips around the motel room. Through the next several scenes, everyone is walking into the strips. Fly strips have an extremely strong adhesive and they would have easily stuck to anything they came in contact with. Nothing stuck to the strips.
In the scene where they are to get the pizza, as they crouch on the floor leaving the money under the door, the dead doctor's foot moves.
The location of the motel is supposed to be in Oklahoma yet the telephone number on the room's telephone has a 504 area code of the filming location in Louisiana.