After filming was done, Eric Bana started filming Star Trek (2009), which required him to shave his head. However, re-shoots for this movie were needed, so production was put on hold so Bana's hair could grow out. It took so long that the movie's release date was pushed back by nearly a year.
The two girls who play Alba are sisters in real life. Tatum McCann plays Alba at four and five years old, while Hailey McCann plays Alba ages nine and ten.
This is one of four movies in which Rachel McAdams stars as the love interest of a time traveler. The other ones are About Time (2013), in which she played the wife to Domhnall Gleeson's character, Midnight in Paris (2011), in which she played the fiancée of Owen Wilson's character, and Doctor Strange (2016), girlfriend of the title character. In none of the films does her character travel through time in any way.
Jennifer Aniston and Brad Pitt made headlines when they bought the film rights to Audrey Niffenegger's novel before it was released to the public.
The song that Alba and her grandfather play on the violin is "Es ist ein Ros entsprungen" or "Lo, How A Rose 'Ere Blooming." This is also the song Henry's mother is singing in the opening scene.