Benita is the name of George Lopez maternal grandmother, who raised George after he was abandoned by his parents.
Masiela Lusha (Carmen) was the only member of the main cast to not be of Latin descent; she is Albanian.
In every episode a new inspirational saying is written on the chalkboard on the side of the kitchen refrigerator.
During an appearance on The Sharon Osbourne Show (2003) George Lopez revealed it was his wife who first suggested Constance Marie for the role of George's TV wife Angie.