This was the highest grossing film in which Robert De Niro has ever appeared, until Joker (2019) passed it in 2019.
Alanna Ubach, who played Greg's former housekeeper Isabelle, is actually ten years younger than Ben Stiller.
James Brolin was originally approached for the role of Bernie, but turned it down. When director Jay Roach went to approach Dustin Hoffman for the role, Hoffman was talking non-stop, and even out of the point, which made him the instant choice for Bernie.