This was the last Flintstones project created and produced by both William Hanna, who died in 2001, and Joseph Barbera, who died in 2006.
The first time anyone other than Jean Vander Pyl voiced the adult Wilma Flintstone since her creation in 1966, due to the actress' death.
The last time an original cast member from the 1960s worked on a Flintstones project, with John Stephenson reprising his role as Mr. Slate.
Jeff Bergman reprised his role as Fred Flintstone in two episodes of Seth MacFarlane's Cavalcade of Cartoon Comedy (2008).
It is the only Flintstones movie production to be produced by Cartoon Network Studios after the Hanna-Barbera studios was absorbed into Warner Bros. Animation in 2001. In format, the movie was intended to emulate the first and second seasons of The Flintstones (1960) series, which was distinctly more mature and aimed at older audiences than the later seasons, and therefore chose to focus more on the relationships between the original core cast of Fred, Barney, Wilma and Betty.