In the swamp scene when Susan Orlean is cradling John Laroche's head, the hair on his forehead is totally disheveled. Then, in a closeup, his hair sweeps neatly across his forehead. Back to the wider shot, and his hair is disheveled again.
When Charlie is getting take-out from the restaurant and bumps into Valerie, he leaves the restaurant in a hurry and does not take his bag of food. In the next scene, he is eating the food.
In the beginning, when John is trudging through the swamp searching for orchids, he is up to his armpits in water. Once out of the water, when the park enforcement officer approaches them, the water line on Laroche's shirt is seen as just above the waist - about a foot lower than the point to which he was submerged.
When Susan Orlean and John Laroche are lost in the swamp, the light is overcast both when John is sitting and when he wades off, but Susan is standing beside him in bright sunlight.
When Susan talks to John in her hotel room, the cord that runs out of her phone is clearly seen, but when the conversation continues as Susan lies on the floor, the cord is gone.
When Susan is brushing her teeth, the sound of brushing continues when she has already stopped. This was done on purpose to show the effects of the drug kicking in.
When Susan talks about past orchid hunters, one in China is seen being beaten to death. As his attacker stands, he pulls off his fake beard.
When Donald and Charlie are in the kitchen, they pass each other. It looks as though they walk right through one another.
When Charlie opens the passenger (right) door of the rental car, a buzzer is heard, warning that the key was left in the ignition. The buzzer should only sound when the driver (left) door is open.
At the end when Charlie pulls out of the parking garage, crew member Jennifer Porst sits next to him in the car for a single shot, though he is riding alone.
When the accident involving John, his wife, mother, and uncle occurs, the spring holding the uncle dummy's head can be seen as the car is pushed to the left.
Donald suggests "Flowers for Algernon" as an example of a movie about flowers, to which Charlie replies, "It's not about flowers; besides it's not a movie." In fact, the book has been filmed twice - once as Charly (1968) and for television as Flowers for Algernon (2000).
When John Laroche talked about a bee pollinating orchids, he said a bee is attracted to orchids that look like it is making love to the flower. Well, a pollinating bee is a female; it's purpose is solely to extract nectar from the flower. It was never lust. As an horticulturist, Laroche should know better.